{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T14:37:37Z","timestamp":1789915057158,"version":"4.0.1"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Although dendritic cells (DCs) have been widely demonstrated to play essential roles in initiation of Th2 responses in helminth infections and allergic reactions, the mechanisms remain uncertain largely because DCs do not produce IL-4. In present investigation, we have uncovered a novel subset of DCs from mice infected with Th2-provoking pathogens \u00a0Schistosoma japonica, which independently promoted Th2 cells via IL-4\u2013dependent pathway. These DCs contained similar levels of IL-4 mRNA and higher levels of IL-12p40 mRNA comparing to basophils, correlating to their Th2-promoting and Th1-promoting dual polarization capacities. Characterized by expression of Fc\u03b5RI+, these DCs were induced independent of T cells. Further investigations revealed that Th2-promoting Fc\u03b5RI+ DCs were monocyte-derived inflammatory DCs, which were sufficient to induce Th2 cells in vivo. Egg Ags together with GM-CSF or IL-3 alone were able to stimulate the generation of Th2-promoting Fc\u03b5RI+ DCs from bone marrow cells in vitro. To our knowledge, our data for the first time demonstrate that IL-4\u2013producing DCs are induced under some Th2-provoking situations, and they should play important roles in initiation of Th2 response.<\/jats:p>","DOI":"10.4049\/jimmunol.1403240","type":"journal-article","created":{"date-parts":[[2015,9,12]],"date-time":"2015-09-12T02:14:11Z","timestamp":1442024051000},"page":"3769-3780","source":"Crossref","is-referenced-by-count":19,"title":["IL-4\u2013Producing Dendritic Cells Induced during <i>Schistosoma japonica<\/i> Infection Promote Th2 Cells via IL-4\u2013Dependent Pathway"],"prefix":"10.1093","volume":"195","author":[{"given":"Yi-Lei","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Immunology and Pathogen Biology, Tongji University School of Medicine , Shanghai 200092 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Juan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Immunology and Pathogen Biology, Tongji University School of Medicine , Shanghai 200092 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Cong","sequence":"additional","affiliation":[{"name":"Department of Immunology and Pathogen Biology, Tongji University School of Medicine , Shanghai 200092 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Ci","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Immunology and Pathogen Biology, Tongji University School of Medicine , Shanghai 200092 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Mei","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Immunology and Pathogen Biology, Tongji University School of Medicine , Shanghai 200092 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Immunology and Pathogen Biology, Tongji University School of Medicine , Shanghai 200092 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Xia","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Immunology and Pathogen Biology, Tongji University School of Medicine , Shanghai 200092 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nian-Yu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Immunology and Pathogen Biology, Tongji University School of Medicine , Shanghai 200092 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Lu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Immunology and Pathogen Biology, Tongji University School of Medicine , Shanghai 200092 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Immunology and Pathogen Biology, Tongji University School of Medicine , Shanghai 200092 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ping","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Immunology and Pathogen Biology, Tongji University School of Medicine , Shanghai 200092 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,10,15]]},"reference":[{"key":"2025030704190198100_r1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/imr.12032","article-title":"Early signaling events that underlie fate decisions of naive CD4+ T cells toward distinct T-helper cell subsets","volume":"252","author":"Yamane","year":"2013","journal-title":"Immunol. 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