{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:08:01Z","timestamp":1791616081924,"version":"4.3.4"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The skin is an important barrier organ and frequent target of autoimmunity and allergy. In this study, we found innate-like B cells that expressed the anti-inflammatory cytokine IL-10 in the skin of humans and mice. Unexpectedly, innate-like B1 and conventional B2 cells showed differential homing capacities with peritoneal B1 cells preferentially migrating into the inflamed skin of mice. Importantly, the skin-homing B1 cells included IL-10\u2013secreting cells. B1 cell homing into the skin was independent of typical skin-homing trafficking receptors and instead required \u03b14\u03b21-integrin. Moreover, B1 cells constitutively expressed activated \u03b21 integrin and relocated from the peritoneum to the inflamed skin and intestine upon innate stimulation, indicating an inherent propensity to extravasate into inflamed and barrier sites. We conclude that innate-like B cells migrate from central reservoirs into skin, adding an important cell type with regulatory and protective functions to the skin immune system.<\/jats:p>","DOI":"10.4049\/jimmunol.1403246","type":"journal-article","created":{"date-parts":[[2016,2,6]],"date-time":"2016-02-06T03:14:29Z","timestamp":1454728469000},"page":"2514-2525","source":"Crossref","is-referenced-by-count":69,"title":["IL-10+ Innate-like B Cells Are Part of the Skin Immune System and Require \u03b14\u03b21 Integrin To Migrate between the Peritoneum and Inflamed Skin"],"prefix":"10.1093","volume":"196","author":[{"given":"Skye A","family":"Geherin","sequence":"first","affiliation":[{"name":"Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine , Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6015-339X","authenticated-orcid":false,"given":"Daniela","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine , Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raisa A","family":"Glabman","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine , Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"Ruthel","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine , Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1518-5717","authenticated-orcid":false,"given":"Alf","family":"Hamann","sequence":"additional","affiliation":[{"name":"Deutsches Rheumaforschungszentrum , 10117 Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4208-7362","authenticated-orcid":false,"given":"Gudrun F","family":"Debes","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine , Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,3,15]]},"reference":[{"key":"2025030702143995100_r1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/978-1-84800-165-7_2","volume-title":"Clinical and Basic Immunodermatolgy.","author":"Bos","year":"2008"},{"key":"2025030702143995100_r2","doi-asserted-by":"crossref","first-page":"6027","DOI":"10.4049\/jimmunol.1102639","article-title":"The skin, a novel niche for recirculating B cells","volume":"188","author":"Geherin","year":"2012","journal-title":"J. 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