{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T05:40:15Z","timestamp":1741326015799,"version":"3.38.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In this study, we evaluated the effect chronic helminth infection has on allergic disease in mice previously sensitized to OVA. Ten weeks of infection with Litomosoides sigmodontis reduced immunological markers of type I hypersensitivity, including OVA-specific IgE, basophil activation, and mast cell degranulation. Despite these reductions, there was no protection against immediate clinical hypersensitivity following intradermal OVA challenge. However, late-phase ear swelling, due to type III hypersensitivity, was significantly reduced in chronically infected animals. Levels of total IgG2a, OVA-specific IgG2a, and OVA-specific IgG1 were reduced in the setting of infection. These reductions were most likely due to increased Ab catabolism as ELISPOT assays demonstrated that infected animals do not have suppressed Ab production. Ear histology 24 h after challenge showed infected animals have reduced cellular infiltration in the ear, with significant decreases in numbers of neutrophils and macrophages. Consistent with this, infected animals had less neutrophil-specific chemokines CXCL-1 and CXCL-2 in the ear following challenge. Additionally, in vitro stimulation with immune complexes resulted in significantly less CXCL-1 and CXCL-2 production by eosinophils from chronically infected mice. Expression of Fc\u03b3RI was also significantly reduced on eosinophils from infected animals. These data indicate that chronic filarial infection suppresses eosinophilic responses to Ab-mediated activation and has the potential to be used as a therapeutic for pre-existing hypersensitivity diseases.<\/jats:p>","DOI":"10.4049\/jimmunol.1500081","type":"journal-article","created":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T01:59:09Z","timestamp":1441072749000},"page":"2973-2984","source":"Crossref","is-referenced-by-count":12,"title":["Ten Weeks of Infection with a Tissue-Invasive Helminth Protects against Local Immune Complex\u2013Mediated Inflammation, but Not Cutaneous Type I Hypersensitivity, in Previously Sensitized Mice"],"prefix":"10.1093","volume":"195","author":[{"given":"Holly","family":"Evans","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Uniformed Services University , Bethesda, MD 20814"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin E","family":"Killoran","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Iowa State University , Ames, IA 50011"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blima K","family":"Mitre","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Pittsburgh Medical Center Passavant Hospital , Pittsburgh, PA 15213"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C Paul","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Uniformed Services University , Bethesda, MD 20814"},{"name":"National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So-Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Uniformed Services University , Bethesda, MD 20814"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Mitre","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Uniformed Services University , Bethesda, MD 20814"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,10,1]]},"reference":[{"key":"2025030704144347100_r1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jaci.2009.08.006","article-title":"Trichuris suis ova therapy for allergic rhinitis: a randomized, double-blind, placebo-controlled clinical trial","volume":"125","author":"Bager","year":"2010","journal-title":"J. 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