{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T15:38:21Z","timestamp":1765294701755,"version":"3.38.0"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Devil facial tumor disease (DFTD) is a transmissible cancer that has killed most of the Tasmanian devil (Sarcophilus harrissii) population. Since the first case appeared in the mid-1990s, it has spread relentlessly across the Tasmanian devil\u2019s geographic range. As Tasmanian devils only exist in Tasmania, Australia, DFTD has the potential to cause extinction of this species. The origin of DFTD was a Schwann cell from a female devil. The disease is transmitted when devils bite each other around the facial areas, a behavior synonymous with this species. Every devil that is \u2018infected\u2019 with DFTD dies from the cancer. Once the DFTD cells have been transmitted, they appear to develop into a cancer without inducing an immune response. The DFTD cancer cells avoid allogeneic recognition because they do not express MHC class I molecules on the cell surface. A reduced genetic diversity and the production of immunosuppressive cytokines may also contribute.<\/jats:p>","DOI":"10.4049\/jimmunol.1500131","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T20:34:21Z","timestamp":1434746061000},"page":"23-29","source":"Crossref","is-referenced-by-count":26,"title":["Immunology of a Transmissible Cancer Spreading among Tasmanian Devils"],"prefix":"10.1093","volume":"195","author":[{"given":"Gregory M","family":"Woods","sequence":"first","affiliation":[{"name":"Menzies Institute for Medical Research, University of Tasmania , Hobart, Tasmania 7000 ,","place":["Australia"]},{"name":"School of Medicine, University of Tasmania , Hobart, Tasmania 7001 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren J","family":"Howson","sequence":"additional","affiliation":[{"name":"Menzies Institute for Medical Research, University of Tasmania , Hobart, Tasmania 7000 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella K","family":"Brown","sequence":"additional","affiliation":[{"name":"Menzies Institute for Medical Research, University of Tasmania , Hobart, Tasmania 7000 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesar","family":"Tovar","sequence":"additional","affiliation":[{"name":"Menzies Institute for Medical Research, University of Tasmania , Hobart, Tasmania 7000 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Kreiss","sequence":"additional","affiliation":[{"name":"Menzies Institute for Medical Research, University of Tasmania , Hobart, Tasmania 7000 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn M","family":"Corcoran","sequence":"additional","affiliation":[{"name":"Walter and Eliza Hall Institute of Medical Research , Parkville, Victoria 3052 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A Bruce","family":"Lyons","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Tasmania , Hobart, Tasmania 7001 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,7,1]]},"reference":[{"key":"2025030703413814000_r1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1634\/theoncologist.2010-0301","article-title":"Contagious cancer","volume":"16","author":"Welsh","year":"2011","journal-title":"Oncologist"},{"key":"2025030703413814000_r2","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1097\/CMR.0b013e32833faf6a","article-title":"Spontaneous regression of transplacental metastases from maternal melanoma in a newborn: case report and review of the literature","volume":"20","author":"Valenzano Menada","year":"2010","journal-title":"Melanoma Res."},{"key":"2025030703413814000_r3","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0065-230X(08)60645-4","article-title":"Tumors arising in organ transplant recipients","volume":"28","author":"Penn","year":"1978","journal-title":"Adv. Cancer Res."},{"key":"2025030703413814000_r4","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1002\/1097-0142(196506)18:6<782::AID-CNCR2820180616>3.0.CO;2-#","article-title":"Fatal homotransplanted melanoma: a case report","volume":"18","author":"Scanlon","year":"1965","journal-title":"Cancer"},{"key":"2025030703413814000_r5","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.cell.2011.11.065","article-title":"Genome sequencing and analysis of the Tasmanian devil and its transmissible cancer","volume":"148","author":"Murchison","year":"2012","journal-title":"Cell"},{"key":"2025030703413814000_r6","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1126\/science.1180616","article-title":"The Tasmanian devil transcriptome reveals Schwann cell origins of a clonally transmissible cancer","volume":"327","author":"Murchison","year":"2010","journal-title":"Science"},{"key":"2025030703413814000_r7","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.biocon.2006.04.010","article-title":"Emerging disease and population decline of an island endemic, the Tasmanian devil Sarcophilus harrisii","volume":"131","author":"Hawkins","year":"2006","journal-title":"Biol. Conserv."},{"key":"2025030703413814000_r8","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1007\/s10393-007-0126-0","article-title":"Towards a case definition for devil facial tumour disease: what is it?","volume":"4","author":"Pyecroft","year":"2007","journal-title":"EcoHealth"},{"key":"2025030703413814000_r9","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1111\/j.1365-2656.2007.01272.x","article-title":"The impact of disease on the survival and population growth rate of the Tasmanian devil","volume":"76","author":"Lachish","year":"2007","journal-title":"J. Anim. Ecol."},{"key":"2025030703413814000_r10","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1126\/science.1247167","article-title":"Transmissible dog cancer genome reveals the origin and history of an ancient cell lineage","volume":"343","author":"Murchison","year":"2014","journal-title":"Science"},{"key":"2025030703413814000_r11","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0014-2964(73)90090-X","article-title":"The biological behaviour of the transmissible venereal tumour in immunosuppressed dogs","volume":"9","author":"Cohen","year":"1973","journal-title":"Eur. J. Cancer"},{"key":"2025030703413814000_r12","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1038\/onc.2009.350","article-title":"Clonally transmissible cancers in dogs and Tasmanian devils","volume":"27","author":"Murchison","year":"2008","journal-title":"Oncogene"},{"key":"2025030703413814000_r13","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.cell.2006.05.051","article-title":"Clonal origin and evolution of a transmissible cancer","volume":"126","author":"Murgia","year":"2006","journal-title":"Cell"},{"key":"2025030703413814000_r14","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1186\/s12917-014-0168-9","article-title":"The changing global distribution and prevalence of canine transmissible venereal tumour","volume":"10","author":"Strakova","year":"2014","journal-title":"BMC Vet. Res."},{"key":"2025030703413814000_r15","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/imm.12377","article-title":"Immunology of naturally transmissible tumours","volume":"144","author":"Siddle","year":"2015","journal-title":"Immunology"},{"key":"2025030703413814000_r16","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/bies.201100161","article-title":"Contagious cancer: lessons from the devil and the dog","volume":"34","author":"Belov","year":"2012","journal-title":"BioEssays"},{"key":"2025030703413814000_r17","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1354\/vp.43-6-890","article-title":"The pathology of devil facial tumor disease (DFTD) in Tasmanian devils (Sarcophilus harrisii)","volume":"43","author":"Loh","year":"2006","journal-title":"Vet. Pathol."},{"key":"2025030703413814000_r18","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1177\/0300985811400447","article-title":"Tumor-specific diagnostic marker for transmissible facial tumors of Tasmanian devils: immunohistochemistry studies","volume":"48","author":"Tovar","year":"2011","journal-title":"Vet. Pathol."},{"key":"2025030703413814000_r19","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/439549a","article-title":"Allograft theory: transmission of devil facial-tumour disease","volume":"439","author":"Pearse","year":"2006","journal-title":"Nature"},{"key":"2025030703413814000_r20","doi-asserted-by":"crossref","first-page":"12348","DOI":"10.1073\/pnas.1102838108","article-title":"Genetic diversity and population structure of the endangered marsupial Sarcophilus harrisii (Tasmanian devil)","volume":"108","author":"Miller","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030703413814000_r21","doi-asserted-by":"crossref","first-page":"16221","DOI":"10.1073\/pnas.0704580104","article-title":"Transmission of a fatal clonal tumor by biting occurs due to depleted MHC diversity in a threatened carnivorous marsupial","volume":"104","author":"Siddle","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030703413814000_r22","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1071\/ZO9930507","article-title":"A field-study of communication and social-behavior of the Tasmanian devil at feeding sites","volume":"41","author":"Pemberton","year":"1993","journal-title":"Aust. J. Zool."},{"key":"2025030703413814000_r23","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/j.1523-1739.2011.01747.x","article-title":"Reduced effect of Tasmanian devil facial tumor disease at the disease front","volume":"26","author":"Hamede","year":"2012","journal-title":"Conserv. Biol."},{"key":"2025030703413814000_r24","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1111\/j.1442-9993.2007.01827.x","article-title":"Seasonal, demographic and density-related patterns of contact between Tasmanian devils (Sarcophilus harrisii): implications for transmission of devil facial tumour disease","volume":"33","author":"Hamede","year":"2008","journal-title":"Austral Ecol."},{"key":"2025030703413814000_r25","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0147-9571(94)90005-1","article-title":"\u201cNot proper mammals\u201d: immunity in monotremes and marsupials","volume":"17","author":"Jurd","year":"1994","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"key":"2025030703413814000_r26","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0145-305X(89)90019-0","article-title":"Immune response of a marsupial (Monodelphis domestica) to sheep red blood cells","volume":"13","author":"Croix","year":"1989","journal-title":"Dev. Comp. Immunol."},{"key":"2025030703413814000_r27","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1086\/314517","article-title":"Primary Mycobacterium avium complex infections correlate with lowered cellular immune reactivity in Matschie\u2019s tree kangaroos (Dendrolagus matschiei)","volume":"178","author":"Montali","year":"1998","journal-title":"J. Infect. Dis."},{"key":"2025030703413814000_r28","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0165-2427(92)90084-4","article-title":"Isolation of koala lymphoid cells and their in vitro responses to mitogens","volume":"31","author":"Wilkinson","year":"1992","journal-title":"Vet. Immunol. Immunopathol."},{"key":"2025030703413814000_r29","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1097\/00007890-197602000-00015","article-title":"Proliferative reactivity of opossum peripheral blood leukocytes allogeneic cells, mitogens, and specific antigens","volume":"21","author":"Fox","year":"1976","journal-title":"Transplantation"},{"key":"2025030703413814000_r30","first-page":"184","article-title":"Absence of a significant mixed lymphocyte reaction in a marsupial (Monodelphis domestica)","volume":"48","author":"Stone","year":"1998","journal-title":"Lab. Anim. Sci."},{"key":"2025030703413814000_r31","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s11259-007-0057-9","article-title":"Culture and stimulation of tammar wallaby lymphocytes","volume":"31","author":"Young","year":"2007","journal-title":"Vet. Res. Commun."},{"key":"2025030703413814000_r32","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.dci.2007.09.002","article-title":"Assessment of cellular immune responses of healthy and diseased Tasmanian devils (Sarcophilus harrisii)","volume":"32","author":"Kreiss","year":"2008","journal-title":"Dev. Comp. Immunol."},{"key":"2025030703413814000_r33","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1007\/s10393-007-0117-1","article-title":"The immune response of the Tasmanian devil (Sarcophilus harrisii) and devil facial tumour disease","volume":"4","author":"Woods","year":"2007","journal-title":"EcoHealth"},{"key":"2025030703413814000_r34","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1002\/ar.20896","article-title":"A histological and immunohistochemical analysis of lymphoid tissues of the Tasmanian devil","volume":"292","author":"Kreiss","year":"2009","journal-title":"Anat. Rec. (Hoboken)"},{"key":"2025030703413814000_r35","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1002\/ar.22904","article-title":"Identification of dendritic cells, B cell and T cell subsets in Tasmanian devil lymphoid tissue; evidence for poor immune cell infiltration into devil facial tumors","volume":"297","author":"Howson","year":"2014","journal-title":"Anat. Rec. (Hoboken)"},{"key":"2025030703413814000_r36","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.vetimm.2009.02.003","article-title":"The humoral immune response of the Tasmanian devil (Sarcophilus harrisii) against horse red blood cells","volume":"130","author":"Kreiss","year":"2009","journal-title":"Vet. Immunol. Immunopathol."},{"key":"2025030703413814000_r37","doi-asserted-by":"crossref","first-page":"e24475","DOI":"10.1371\/journal.pone.0024475","article-title":"Natural killer cell mediated cytotoxic responses in the Tasmanian devil","volume":"6","author":"Brown","year":"2011","journal-title":"PLoS ONE"},{"key":"2025030703413814000_r38","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1111\/j.1365-294X.2004.02239.x","article-title":"Genetic diversity and population structure of Tasmanian devils, the largest marsupial carnivore","volume":"13","author":"Jones","year":"2004","journal-title":"Mol. Ecol."},{"key":"2025030703413814000_r39","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1046\/j.1471-8286.2003.00425.x","article-title":"Microsatellites for the Tasmanian devil (Sarcophilus laniarius)","volume":"3","author":"Jones","year":"2003","journal-title":"Mol. Ecol. Notes"},{"key":"2025030703413814000_r40","doi-asserted-by":"crossref","first-page":"20140619","DOI":"10.1098\/rsbl.2014.0619","article-title":"Extensive population decline in the Tasmanian devil predates European settlement and devil facial tumour disease","volume":"10","author":"Br\u00fcniche-Olsen","year":"2014","journal-title":"Biol. Lett."},{"key":"2025030703413814000_r41","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1126\/science.2983425","article-title":"Genetic basis for species vulnerability in the cheetah","volume":"227","author":"O\u2019Brien","year":"1985","journal-title":"Science"},{"key":"2025030703413814000_r42","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1093\/molbev\/msq330","article-title":"Cheetah paradigm revisited: MHC diversity in the world\u2019s largest free-ranging population","volume":"28","author":"Castro-Prieto","year":"2011","journal-title":"Mol. Biol. Evol."},{"key":"2025030703413814000_r43","doi-asserted-by":"crossref","first-page":"e22402","DOI":"10.1371\/journal.pone.0022402","article-title":"Allorecognition in the Tasmanian devil (Sarcophilus harrisii), an endangered marsupial species with limited genetic diversity","volume":"6","author":"Kreiss","year":"2011","journal-title":"PLoS ONE"},{"key":"2025030703413814000_r44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.immunol.18.1.1","article-title":"Discovering the role of the major histocompatibility complex in the immune response","volume":"18","author":"McDevitt","year":"2000","journal-title":"Annu. Rev. Immunol."},{"key":"2025030703413814000_r45","first-page":"2001","article-title":"MHC gene copy number variation in Tasmanian devils: implications for the spread of a contagious cancer","volume":"277","author":"Siddle","year":"2010","journal-title":"Proc. Biol. Sci."},{"key":"2025030703413814000_r46","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1136\/jcp.54.8.631","article-title":"Malignant peripheral nerve sheath tumour arising within neurofibroma. An immunoochemical analysis in the comparison between benign and malignant components","volume":"54","author":"Watanabe","year":"2001","journal-title":"J. Clin. Pathol."},{"key":"2025030703413814000_r47","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.vetimm.2013.02.008","article-title":"Does the devil facial tumour produce immunosuppressive cytokines as an immune evasion strategy?","volume":"153","author":"Morris","year":"2013","journal-title":"Vet. Immunol. Immunopathol."},{"key":"2025030703413814000_r48","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/ijc.2910550118","article-title":"Interleukin-10 production by human carcinoma cell lines and its relationship to interleukin-6 expression","volume":"55","author":"Gastl","year":"1993","journal-title":"Int. J. Cancer"},{"key":"2025030703413814000_r49","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1084\/jem.174.5.1209","article-title":"Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes","volume":"174","author":"de Waal Malefyt","year":"1991","journal-title":"J. Exp. Med."},{"key":"2025030703413814000_r50","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s00262-006-0160-8","article-title":"Tumor-derived CD4+CD25+ regulatory T cell suppression of dendritic cell function involves TGF-\u03b2 and IL-10","volume":"56","author":"Larmonier","year":"2007","journal-title":"Cancer Immunol. Immunother."},{"key":"2025030703413814000_r51","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0145-305X(00)00010-0","article-title":"Marsupial cytokines. Structure, function and evolution","volume":"24","author":"Harrison","year":"2000","journal-title":"Dev. Comp. Immunol."},{"key":"2025030703413814000_r52","doi-asserted-by":"crossref","first-page":"7155","DOI":"10.1016\/S0021-9258(18)32345-7","article-title":"Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization","volume":"258","author":"Assoian","year":"1983","journal-title":"J. Biol. Chem."},{"key":"2025030703413814000_r53","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.4049\/jimmunol.0902133","article-title":"Tolerogenic dendritic cells generated with different immunosuppressive cytokines induce antigen-specific anergy and regulatory properties in memory CD4+ T cells","volume":"184","author":"Torres-Aguilar","year":"2010","journal-title":"J. Immunol."},{"key":"2025030703413814000_r54","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s00262-009-0809-1","article-title":"Testing the theory of immune selection in cancers that break the rules of transplantation","volume":"59","author":"Fassati","year":"2010","journal-title":"Cancer Immunol. Immunother."},{"key":"2025030703413814000_r55","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/sj.bjc.6602918","article-title":"Epigenetics provides a new generation of oncogenes and tumour-suppressor genes","volume":"94","author":"Esteller","year":"2006","journal-title":"Br. J. Cancer"},{"key":"2025030703413814000_r56","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/jcp.10290","article-title":"MHC class I antigens, immune surveillance, and tumor immune escape","volume":"195","author":"Garcia-Lora","year":"2003","journal-title":"J. Cell. Physiol."},{"key":"2025030703413814000_r57","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.neulet.2005.12.027","article-title":"Immune system evasion by peripheral nerve sheath tumor","volume":"397","author":"Lee","year":"2006","journal-title":"Neurosci. Lett."},{"key":"2025030703413814000_r58","doi-asserted-by":"crossref","first-page":"5103","DOI":"10.1073\/pnas.1219920110","article-title":"Reversible epigenetic down-regulation of MHC molecules by devil facial tumour disease illustrates immune escape by a contagious cancer","volume":"110","author":"Siddle","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030703413814000_r59","doi-asserted-by":"crossref","first-page":"6062","DOI":"10.1073\/pnas.0400782101","article-title":"A gene atlas of the mouse and human protein-encoding transcriptomes","volume":"101","author":"Su","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030703413814000_r60","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/nri2506","article-title":"Myeloid-derived suppressor cells as regulators of the immune system","volume":"9","author":"Gabrilovich","year":"2009","journal-title":"Nat. Rev. Immunol."},{"volume-title":"Doctoral dissertation","year":"2013","author":"Brown","key":"2025030703413814000_r61"},{"key":"2025030703413814000_r62","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0167-5699(90)90097-S","article-title":"In search of the \u201cmissing self\u201d: MHC molecules and NK cell recognition","volume":"11","author":"Ljunggren","year":"1990","journal-title":"Immunol. Today"},{"key":"2025030703413814000_r63","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3389\/fimmu.2014.00251","article-title":"Mouse model of Devil facial tumour disease establishes that an effective immune response can be generated against the cancer cells","volume":"5","author":"Pinfold","year":"2014","journal-title":"Front. Immunol."},{"key":"2025030703413814000_r64","doi-asserted-by":"crossref","DOI":"10.1016\/j.vaccine.2015.01.039","article-title":"Evidence for induction of humoral and cytotoxic immune responses against devil facial tumor disease cells in Tasmanian devils (Sarcophilus harrisii) immunized with killed cell preparations","author":"Kreiss","year":"2015","journal-title":"Vaccine"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/195\/1\/23\/62246045\/1500131.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/195\/1\/23\/62246045\/1500131.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T03:43:08Z","timestamp":1741318988000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/195\/1\/23\/7973172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,1]]},"references-count":64,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,7,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1500131","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"type":"print","value":"0022-1767"},{"type":"electronic","value":"1550-6606"}],"subject":[],"published-other":{"date-parts":[[2015,7]]},"published":{"date-parts":[[2015,7,1]]}}}