{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T05:49:11Z","timestamp":1763358551061,"version":"3.38.0"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>There is a lack of an HSV-2 vaccine, in part as the result of various factors that limit robust and long-term memory immune responses at the mucosal portals of viral entry. We previously demonstrated that chemokine CCL19 augmented mucosal and systemic immune responses to HIV-1 envelope glycoprotein. Whether such enhanced immunity can protect animals against virus infection remains to be addressed. We hypothesized that using CCL19 in a fusion form to direct an immunogen to responsive immunocytes might have an advantage over CCL19 being used in combination with an immunogen. We designed two fusion constructs, plasmid (p)gBIZCCL19 and pCCL19IZgB, by fusing CCL19 to the C- or N-terminal end of the extracellular HSV-2 glycoprotein B (gB) with a linker containing two (Gly4Ser)2 repeats and a GCN4-based isoleucine zipper motif for self-oligomerization. Following immunization in mice, pgBIZCCL19 and pCCL19IZgB induced strong gB-specific IgG and IgA in sera and vaginal fluids. The enhanced systemic and mucosal Abs showed increased neutralizing activity against HSV-2 in vitro. Measurement of gB-specific cytokines demonstrated that gB-CCL19 fusion constructs induced balanced Th1 and Th2 cellular immune responses. Moreover, mice vaccinated with fusion constructs were well protected from intravaginal lethal challenge with HSV-2. Compared with pgB and pCCL19 coimmunization, fusion constructs increased mucosal surface IgA+ cells, as well as CCL19-responsive immunocytes in spleen and mesenteric lymph nodes. Our findings indicate that enhanced humoral and cellular immune responses can be achieved by immunization with an immunogen fused to a chemokine, providing information for the design of vaccines against mucosal infection by HSV-2 and other sexually transmitted viruses.<\/jats:p>","DOI":"10.4049\/jimmunol.1500198","type":"journal-article","created":{"date-parts":[[2015,5,21]],"date-time":"2015-05-21T02:01:44Z","timestamp":1432173704000},"page":"329-338","source":"Crossref","is-referenced-by-count":16,"title":["Immunization with HSV-2 gB-CCL19 Fusion Constructs Protects Mice against Lethal Vaginal Challenge"],"prefix":"10.1093","volume":"195","author":[{"given":"Yan","family":"Yan","sequence":"first","affiliation":[{"name":"State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences , Wuhan 430071 ,","place":["China"]},{"name":"University of Chinese Academy of Sciences , Beijing 100049 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences , Wuhan 430071 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Deng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences , Wuhan 430071 ,","place":["China"]},{"name":"University of Chinese Academy of Sciences , Beijing 100049 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinmeng","family":"Guan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences , Wuhan 430071 ,","place":["China"]},{"name":"University of Chinese Academy of Sciences , Beijing 100049 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukun","family":"Luo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences , Wuhan 430071 ,","place":["China"]},{"name":"University of Chinese Academy of Sciences , Beijing 100049 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Tong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences , Wuhan 430071 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Du","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences , Wuhan 430071 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Fu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences , Wuhan 430071 ,","place":["China"]},{"name":"University of Chinese Academy of Sciences , Beijing 100049 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mudan","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences , Wuhan 430071 ,","place":["China"]},{"name":"University of Chinese Academy of Sciences , Beijing 100049 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yalan","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences , Wuhan 430071 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinxue","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences , Wuhan 430071 ,","place":["China"]},{"name":"Institute for Infection and Immunity, St. George\u2019s University of London , London SW17 0RE ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,7,1]]},"reference":[{"key":"2025030703413842100_r1","doi-asserted-by":"crossref","first-page":"e635","DOI":"10.1542\/peds.2012-3216","article-title":"Guidance on management of asymptomatic neonates born to women with active genital herpes lesions","volume":"131","author":"Kimberlin","year":"2013","journal-title":"Pediatrics"},{"key":"2025030703413842100_r2","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s12250-014-3539-2","article-title":"Ocular herpes: the pathophysiology, management and treatment of herpetic eye diseases","volume":"29","author":"Zhu","year":"2014","journal-title":"Virol. Sin."},{"key":"2025030703413842100_r3","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1097\/00002030-200202150-00018","article-title":"Herpes simplex virus type 2 infection increases HIV incidence: a prospective study in rural Tanzania","volume":"16","author":"del Mar Pujades Rodr\u00edguez","year":"2002","journal-title":"AIDS"},{"key":"2025030703413842100_r4","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1097\/QAD.0b013e32831c5497","article-title":"Transmission probabilities of HIV and herpes simplex virus type 2, effect of male circumcision and interaction: a longitudinal study in a township of South Africa","volume":"23","author":"Mahiane","year":"2009","journal-title":"AIDS"},{"key":"2025030703413842100_r5","doi-asserted-by":"crossref","first-page":"371","DOI":"10.3390\/v6020371","article-title":"HSV-2 vaccine: current status and insight into factors for developing an efficient vaccine","volume":"6","author":"Zhu","year":"2014","journal-title":"Viruses"},{"key":"2025030703413842100_r6","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1126\/science.330.6002.304","article-title":"Immunology. Painful failure of promising genital herpes vaccine","volume":"330","author":"Cohen","year":"2010","journal-title":"Science"},{"key":"2025030703413842100_r7","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1128\/JVI.03163-13","article-title":"Protection provided by a herpes simplex virus 2 (HSV-2) glycoprotein C and D subunit antigen vaccine against genital HSV-2 infection in HSV-1-seropositive guinea pigs","volume":"88","author":"Awasthi","year":"2014","journal-title":"J. Virol."},{"key":"2025030703413842100_r8","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1128\/JVI.03200-13","article-title":"Mechanism of neutralization of herpes simplex virus by antibodies directed at the fusion domain of glycoprotein B","volume":"88","author":"Cairns","year":"2014","journal-title":"J. Virol."},{"key":"2025030703413842100_r9","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1128\/JVI.01924-10","article-title":"Impact of valency of a glycoprotein B-specific monoclonal antibody on neutralization of herpes simplex virus","volume":"85","author":"Krawczyk","year":"2011","journal-title":"J. Virol."},{"key":"2025030703413842100_r10","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/978-1-4939-0428-0_21","article-title":"The murine intravaginal HSV-2 challenge model for investigation of DNA vaccines","volume":"1144","author":"Marshak","year":"2014","journal-title":"Methods Mol. Biol."},{"key":"2025030703413842100_r11","doi-asserted-by":"crossref","first-page":"7544","DOI":"10.1128\/JVI.00186-12","article-title":"Glycoprotein G of herpes simplex virus 2 as a novel vaccine antigen for immunity to genital and neurological disease","volume":"86","author":"G\u00f6rander","year":"2012","journal-title":"J. Virol."},{"key":"2025030703413842100_r12","doi-asserted-by":"crossref","first-page":"4600","DOI":"10.1172\/JCI57148","article-title":"HSV-2: in pursuit of a vaccine","volume":"121","author":"Johnston","year":"2011","journal-title":"J. Clin. Invest."},{"key":"2025030703413842100_r13","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.4049\/jimmunol.162.5.2912","article-title":"IL-12 gene as a DNA vaccine adjuvant in a herpes mouse model: IL-12 enhances Th1-type CD4+ T cell-mediated protective immunity against herpes simplex virus-2 challenge","volume":"162","author":"Sin","year":"1999","journal-title":"J. Immunol."},{"key":"2025030703413842100_r14","doi-asserted-by":"crossref","first-page":"12742","DOI":"10.1128\/JVI.77.23.12742-12752.2003","article-title":"Codelivery of CCR7 ligands as molecular adjuvants enhances the protective immune response against herpes simplex virus type 1","volume":"77","author":"Toka","year":"2003","journal-title":"J. Virol."},{"key":"2025030703413842100_r15","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1182\/blood-2003-05-1643","article-title":"CCL19\/CCL21-triggered signal transduction and migration of dendritic cells requires prostaglandin E2","volume":"103","author":"Scandella","year":"2004","journal-title":"Blood"},{"key":"2025030703413842100_r16","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.4049\/jimmunol.1300120","article-title":"CCL19 and CCL28 augment mucosal and systemic immune responses to HIV-1 gp140 by mobilizing responsive immunocytes into secondary lymph nodes and mucosal tissue","volume":"191","author":"Hu","year":"2013","journal-title":"J. Immunol."},{"key":"2025030703413842100_r17","doi-asserted-by":"crossref","first-page":"6851","DOI":"10.4049\/jimmunol.0803568","article-title":"CCR7-CCL19\/CCL21-regulated dendritic cells are responsible for effectiveness of sublingual vaccination","volume":"182","author":"Song","year":"2009","journal-title":"J. Immunol."},{"key":"2025030703413842100_r18","doi-asserted-by":"crossref","first-page":"7118","DOI":"10.1074\/jbc.273.12.7118","article-title":"Secondary lymphoid-tissue chemokine is a functional ligand for the CC chemokine receptor CCR7","volume":"273","author":"Yoshida","year":"1998","journal-title":"J. Biol. Chem."},{"key":"2025030703413842100_r19","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0042-6822(03)00199-5","article-title":"Influence of CCR7 ligand DNA preexposure on the magnitude and duration of immunity","volume":"312","author":"Lee","year":"2003","journal-title":"Virology"},{"key":"2025030703413842100_r20","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1002\/1521-4141(200208)32:8<2133::AID-IMMU2133>3.0.CO;2-W","article-title":"Functional expression of the lymphoid chemokines CCL19 (ELC) and CCL 21 (SLC) at the blood-brain barrier suggests their involvement in G-protein-dependent lymphocyte recruitment into the central nervous system during experimental autoimmune encephalomyelitis","volume":"32","author":"Alt","year":"2002","journal-title":"Eur. J. Immunol."},{"key":"2025030703413842100_r21","doi-asserted-by":"crossref","first-page":"3096","DOI":"10.4049\/jimmunol.161.6.3096","article-title":"EBI1\/CCR7 is a new member of dendritic cell chemokine receptor that is up-regulated upon maturation","volume":"161","author":"Yanagihara","year":"1998","journal-title":"J. Immunol."},{"key":"2025030703413842100_r22","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.immuni.2004.06.014","article-title":"CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions","volume":"21","author":"Ohl","year":"2004","journal-title":"Immunity"},{"key":"2025030703413842100_r23","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.immuni.2005.02.010","article-title":"CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells","volume":"22","author":"Marsland","year":"2005","journal-title":"Immunity"},{"key":"2025030703413842100_r24","doi-asserted-by":"crossref","first-page":"5153","DOI":"10.4049\/jimmunol.176.9.5153","article-title":"The multiple personalities of the chemokine receptor CCR7 in dendritic cells","volume":"176","author":"S\u00e1nchez-S\u00e1nchez","year":"2006","journal-title":"J. Immunol."},{"key":"2025030703413842100_r25","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1182\/blood-2002-01-0260","article-title":"CCL19 induces rapid dendritic extension of murine dendritic cells","volume":"100","author":"Yanagawa","year":"2002","journal-title":"Blood"},{"key":"2025030703413842100_r26","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.4049\/jimmunol.1400339","article-title":"Vector-encoded Helicobacter pylori neutrophil-activating protein promotes maturation of dendritic cells with Th1 polarization and improved migration","volume":"193","author":"Ramachandran","year":"2014","journal-title":"J. Immunol."},{"key":"2025030703413842100_r27","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.it.2003.12.005","article-title":"Chemokines: multiple levels of leukocyte migration control","volume":"25","author":"Moser","year":"2004","journal-title":"Trends Immunol."},{"key":"2025030703413842100_r28","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.molimm.2004.06.040","article-title":"Chemokine-mediated control of T cell traffic in lymphoid and peripheral tissues","volume":"42","author":"Ebert","year":"2005","journal-title":"Mol. Immunol."},{"key":"2025030703413842100_r29","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1365-2567.2004.01859.x","article-title":"Ectopic expression of CCL19 impairs alloimmune response in mice","volume":"112","author":"Krautwald","year":"2004","journal-title":"Immunology"},{"key":"2025030703413842100_r30","doi-asserted-by":"crossref","first-page":"e14611","DOI":"10.5812\/hepatmon.14611","article-title":"Enhancement of immune responses by co-delivery of CCL19\/MIP-3beta chemokine plasmid with HCV core DNA\/protein immunization","volume":"14","author":"Hartoonian","year":"2014","journal-title":"Hepat. Mon."},{"key":"2025030703413842100_r31","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/mi.2007.14","article-title":"Differentiation and homing of IgA-secreting cells","volume":"1","author":"Mora","year":"2008","journal-title":"Mucosal Immunol."},{"key":"2025030703413842100_r32","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/icb.2008.69","article-title":"Genetic co-transfer of CCR7 ligands enhances immunity and prolongs survival against virulent challenge of pseudorabies virus","volume":"87","author":"Han","year":"2009","journal-title":"Immunol. Cell Biol."},{"key":"2025030703413842100_r33","doi-asserted-by":"crossref","first-page":"e37801","DOI":"10.1371\/journal.pone.0037801","article-title":"IL-12 and GM-CSF in DNA\/MVA immunizations against HIV-1 CRF12_BF Nef induced T-cell responses with an enhanced magnitude, breadth and quality","volume":"7","author":"Rodr\u00edguez","year":"2012","journal-title":"PLoS ONE"},{"key":"2025030703413842100_r34","doi-asserted-by":"crossref","first-page":"e60126","DOI":"10.1371\/journal.pone.0060126","article-title":"Chimeric HIV-1 envelope glycoproteins with potent intrinsic granulocyte-macrophage colony-stimulating factor (GM-CSF) activity","volume":"8","author":"Isik","year":"2013","journal-title":"PLoS ONE"},{"key":"2025030703413842100_r35","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1128\/JVI.06259-11","article-title":"Targeting HIV-1 envelope glycoprotein trimers to B cells by using APRIL improves antibody responses","volume":"86","author":"Melchers","year":"2012","journal-title":"J. Virol."},{"key":"2025030703413842100_r36","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1742-4690-8-48","article-title":"A stabilized HIV-1 envelope glycoprotein trimer fused to CD40 ligand targets and activates dendritic cells","volume":"8","author":"Melchers","year":"2011","journal-title":"Retrovirology"},{"key":"2025030703413842100_r37","first-page":"19.11","article-title":"Production and use of trimeric isoleucine zipper fusion proteins to study surface receptor ligand interactions","volume":"19","author":"Watzl","year":"2006","journal-title":"Curr. Protoc. Protein Sci, Chapter"},{"key":"2025030703413842100_r38","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.virol.2003.10.010","article-title":"Efficacy of genital T cell responses to herpes simplex virus type 2 resulting from immunization of the nasal mucosa","volume":"318","author":"Milligan","year":"2004","journal-title":"Virology"},{"key":"2025030703413842100_r39","doi-asserted-by":"crossref","first-page":"4640","DOI":"10.1128\/AAC.00623-12","article-title":"Bifunctional CD4-DC-SIGN fusion proteins demonstrate enhanced avidity to gp120 and inhibit HIV-1 infection and dissemination","volume":"56","author":"Du","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"2025030703413842100_r40","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.virol.2011.11.023","article-title":"Highly conserved HIV-1 gp120 glycans proximal to CD4-binding region affect viral infectivity and neutralizing antibody induction","volume":"423","author":"Huang","year":"2012","journal-title":"Virology"},{"key":"2025030703413842100_r41","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1128\/JVI.79.1.410-418.2005","article-title":"Comparative efficacy and immunogenicity of replication-defective, recombinant glycoprotein, and DNA vaccines for herpes simplex virus 2 infections in mice and guinea pigs","volume":"79","author":"Hoshino","year":"2005","journal-title":"J. Virol."},{"key":"2025030703413842100_r42","doi-asserted-by":"crossref","first-page":"7903","DOI":"10.1128\/jvi.71.10.7903-7910.1997","article-title":"Mutations in the 5\u2032 end of the herpes simplex virus type 2 latency-associated transcript (LAT) promoter affect LAT expression in vivo but not the rate of spontaneous reactivation of genital herpes","volume":"71","author":"Wang","year":"1997","journal-title":"J. Virol."},{"key":"2025030703413842100_r43","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1089\/104454999314917","article-title":"DNA priming-protein boosting enhances both antigen-specific antibody and Th1-type cellular immune responses in a murine herpes simplex virus-2 gD vaccine model","volume":"18","author":"Sin","year":"1999","journal-title":"DNA Cell Biol."},{"key":"2025030703413842100_r44","doi-asserted-by":"crossref","first-page":"3034","DOI":"10.1016\/j.vaccine.2011.10.010","article-title":"Identification of B- and T-cell epitopes from glycoprotein B of herpes simplex virus 2 and evaluation of their immunogenicity and protection efficacy","volume":"30","author":"Liu","year":"2012","journal-title":"Vaccine"},{"key":"2025030703413842100_r45","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1479-5876-10-4","article-title":"Effects of adjuvants on IgG subclasses elicited by virus-like particles","volume":"10","author":"Visciano","year":"2012","journal-title":"J. Transl. Med."},{"key":"2025030703413842100_r46","doi-asserted-by":"crossref","first-page":"3930","DOI":"10.1128\/JVI.02745-12","article-title":"An adjuvanted herpes simplex virus 2 subunit vaccine elicits a T cell response in mice and is an effective therapeutic vaccine in Guinea pigs","volume":"87","author":"Skoberne","year":"2013","journal-title":"J. Virol."},{"key":"2025030703413842100_r47","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.4161\/hv.24043","article-title":"Immunogenicity and safety of different formulations of an adjuvanted glycoprotein D genital herpes vaccine in healthy adults: a double-blind randomized trial","volume":"9","author":"Leroux-Roels","year":"2013","journal-title":"Hum. Vaccin. Immunother."},{"key":"2025030703413842100_r48","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.coviro.2014.02.006","article-title":"Status of prophylactic and therapeutic genital herpes vaccines","volume":"6","author":"Awasthi","year":"2014","journal-title":"Curr Opin Virol"},{"key":"2025030703413842100_r49","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/cgt.2012.78","article-title":"CCL19 as an adjuvant for intradermal gene gun immunization in a Her2\/neu mouse tumor model: improved vaccine efficacy and a role for B cells as APC","volume":"19","author":"Nguyen-Hoai","year":"2012","journal-title":"Cancer Gene Ther."},{"key":"2025030703413842100_r50","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1099\/0022-1317-73-9-2357","article-title":"Vaccination by cholera toxin conjugated to a herpes simplex virus type 2 glycoprotein D peptide","volume":"73","author":"Drew","year":"1992","journal-title":"J. Gen. Virol."},{"key":"2025030703413842100_r51","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.4049\/jimmunol.133.4.1818","article-title":"Cholera toxin B subunit as a carrier protein to stimulate a mucosal immune response","volume":"133","author":"McKenzie","year":"1984","journal-title":"J. Immunol."},{"key":"2025030703413842100_r52","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/371080a0","article-title":"Crystal structure of an isoleucine-zipper trimer","volume":"371","author":"Harbury","year":"1994","journal-title":"Nature"},{"key":"2025030703413842100_r53","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1074\/jbc.274.1.418","article-title":"Incorporation of an isoleucine zipper motif enhances the biological activity of soluble CD40L (CD154)","volume":"274","author":"Morris","year":"1999","journal-title":"J. Biol. Chem."},{"key":"2025030703413842100_r54","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/nri2761","article-title":"Therapeutic antibodies for autoimmunity and inflammation","volume":"10","author":"Chan","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"2025030703413842100_r55","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jcv.2012.07.002","article-title":"HSV IgG antibody inhibits virus detection in CSF","volume":"55","author":"Fening","year":"2012","journal-title":"J. Clin. Virol."},{"key":"2025030703413842100_r56","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1348-0421.1997.tb01872.x","article-title":"Herpes simplex virus-specific IgM, IgA and IgG subclass antibody responses in primary and nonprimary genital herpes patients","volume":"41","author":"Hashido","year":"1997","journal-title":"Microbiol. Immunol."},{"key":"2025030703413842100_r57","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1086\/506477","article-title":"Subtly impaired humoral immunity predisposes to frequently recurring genital herpes simplex virus type 2 infection and herpetic neuralgia","volume":"194","author":"Seppanen","year":"2006","journal-title":"J. Infect. Dis."},{"key":"2025030703413842100_r58","doi-asserted-by":"crossref","first-page":"6242","DOI":"10.4049\/jimmunol.166.10.6242","article-title":"Herpes simplex inhibits the capacity of lymphoblastoid B cell lines to stimulate CD4+ T cells","volume":"166","author":"Barcy","year":"2001","journal-title":"J. Immunol."},{"key":"2025030703413842100_r59","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/jlb.65.3.307","article-title":"Inhibition of IL-4-inducible gene expression in human monocytes by type I and type II interferons","volume":"65","author":"Dickensheets","year":"1999","journal-title":"J. Leukoc. Biol."},{"key":"2025030703413842100_r60","doi-asserted-by":"crossref","first-page":"5707","DOI":"10.4049\/jimmunol.160.12.5707","article-title":"Specific immune induction following DNA-based immunization through in vivo transfection and activation of macrophages\/antigen-presenting cells","volume":"160","author":"Chattergoon","year":"1998","journal-title":"J. Immunol."},{"key":"2025030703413842100_r61","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.4049\/jimmunol.163.5.2393","article-title":"Distribution fate and mechanism of immune modulation following mucosal delivery of plasmid DNA encoding IL-10","volume":"163","author":"Chun","year":"1999","journal-title":"J. Immunol."},{"key":"2025030703413842100_r62","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1034\/j.1600-065X.2003.00041.x","article-title":"Homing of antibody secreting cells","volume":"194","author":"Cyster","year":"2003","journal-title":"Immunol. Rev."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/195\/1\/329\/62248491\/1500198.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/195\/1\/329\/62248491\/1500198.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T03:42:41Z","timestamp":1741318961000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/195\/1\/329\/7973169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,1]]},"references-count":62,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,7,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1500198","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"type":"print","value":"0022-1767"},{"type":"electronic","value":"1550-6606"}],"subject":[],"published-other":{"date-parts":[[2015,7]]},"published":{"date-parts":[[2015,7,1]]}}}