{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:43:31Z","timestamp":1791297811445,"version":"4.1.0"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Dendritic cell immunoreceptor (DCIR) is a C-type lectin receptor mainly expressed in DCs. Dcir\u2212\/\u2212 mice spontaneously develop autoimmune enthesitis and ankylosis accompanied by fibrocartilage proliferation and ectopic ossification. However, the mechanisms of new bone\/cartilage formation in Dcir\u2212\/\u2212 mice remain to be elucidated. In this study, we show that DCIR maintains bone homeostasis by regulating IFN-\u03b3 production under pathophysiological conditions. DCIR deficiency increased bone volume in femurs and caused aberrant ossification in joints, whereas these symptoms were abolished in Rag2\u2212\/\u2212Dcir\u2212\/\u2212 mice. IFN-\u03b3\u2013producing T cells accumulated in lymph nodes and joints of Dcir\u2212\/\u2212 mice, and purified Dcir\u2212\/\u2212 DCs enhanced IFN-\u03b3+ T cell differentiation. The ankylotic changes and bone volume increase were suppressed in the absence of IFN-\u03b3. Thus, IFN-\u03b3 is a positive chondrogenic and osteoblastogenic factor, and DCIR is a crucial regulator of bone metabolism; consequently, both factors are potential targets for therapies directed against bone metabolic diseases.<\/jats:p>","DOI":"10.4049\/jimmunol.1500273","type":"journal-article","created":{"date-parts":[[2015,4,30]],"date-time":"2015-04-30T02:21:29Z","timestamp":1430360489000},"page":"5681-5691","source":"Crossref","is-referenced-by-count":49,"title":["DCIR Maintains Bone Homeostasis by Regulating IFN-\u03b3 Production in T Cells"],"prefix":"10.1093","volume":"194","author":[{"given":"Takumi","family":"Maruhashi","sequence":"first","affiliation":[{"name":"Center for Experimental Medicine and Systems Biology, Institute of Medical Science, The University of Tokyo , Tokyo 108-8639 ,","place":["Japan"]},{"name":"Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo , Tokyo 113-0032 ,","place":["Japan"]},{"name":"Research Institute for Biomedical Sciences, Tokyo University of Science , Chiba 278-0022 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomonori","family":"Kaifu","sequence":"additional","affiliation":[{"name":"Center for Experimental Medicine and Systems Biology, Institute of Medical Science, The University of Tokyo , Tokyo 108-8639 ,","place":["Japan"]},{"name":"Research Institute for Biomedical Sciences, Tokyo University of Science , Chiba 278-0022 ,","place":["Japan"]},{"name":"Core Research for Evolutional Science and Technology, Japan Science and Technology Agency , Saitama 332-0012 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikio","family":"Yabe","sequence":"additional","affiliation":[{"name":"Center for Experimental Medicine and Systems Biology, Institute of Medical Science, The University of Tokyo , Tokyo 108-8639 ,","place":["Japan"]},{"name":"Research Institute for Biomedical Sciences, Tokyo University of Science , Chiba 278-0022 ,","place":["Japan"]},{"name":"Medical Mycology Research Center, Chiba University , Chiba 250-8673 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akimasa","family":"Seno","sequence":"additional","affiliation":[{"name":"Center for Experimental Medicine and Systems Biology, Institute of Medical Science, The University of Tokyo , Tokyo 108-8639 ,","place":["Japan"]},{"name":"Medical Mycology Research Center, Chiba University , Chiba 250-8673 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo-Hyun","family":"Chung","sequence":"additional","affiliation":[{"name":"Center for Experimental Medicine and Systems Biology, Institute of Medical Science, The University of Tokyo , Tokyo 108-8639 ,","place":["Japan"]},{"name":"Research Institute for Biomedical Sciences, Tokyo University of Science , Chiba 278-0022 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Fujikado","sequence":"additional","affiliation":[{"name":"Center for Experimental Medicine and Systems Biology, Institute of Medical Science, The University of Tokyo , Tokyo 108-8639 ,","place":["Japan"]},{"name":"Core Research for Evolutional Science and Technology, Japan Science and Technology Agency , Saitama 332-0012 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichiro","family":"Iwakura","sequence":"additional","affiliation":[{"name":"Center for Experimental Medicine and Systems Biology, Institute of Medical Science, The University of Tokyo , Tokyo 108-8639 ,","place":["Japan"]},{"name":"Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo , Tokyo 113-0032 ,","place":["Japan"]},{"name":"Research Institute for Biomedical Sciences, Tokyo University of Science , Chiba 278-0022 ,","place":["Japan"]},{"name":"Core Research for Evolutional Science and Technology, Japan Science and Technology Agency , Saitama 332-0012 ,","place":["Japan"]},{"name":"Medical Mycology Research Center, Chiba University , Chiba 250-8673 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,6,15]]},"reference":[{"key":"2025030706573735300_r1","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.immuni.2011.05.001","article-title":"Myeloid C-type lectin receptors in pathogen recognition and host defense","volume":"34","author":"Osorio","year":"2011","journal-title":"Immunity"},{"key":"2025030706573735300_r2","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.4049\/jimmunol.163.4.1973","article-title":"APCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motif","volume":"163","author":"Bates","year":"1999","journal-title":"J. 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