{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:18:13Z","timestamp":1791289093039,"version":"4.3.0"},"reference-count":68,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>West Nile virus (WNV) is a re-emerging pathogen and the leading cause of epidemic encephalitis in the United States. Inflammatory monocytes are a critical component of the cellular infiltrate found in the CNS during WNV encephalitis, although the molecular cues involved in their migration are not fully understood. In mice, we previously showed that WNV infection induces a CCR2-dependent monocytosis that precedes monocyte migration into the CNS. Currently, the relative contribution of the CCR2 ligands, chemokines CCL2 and CCL7, in directing monocyte mobilization and leukocyte migration into the CNS is unclear. In this study, we demonstrate that, although both CCL2 and CCL7 are required for efficient monocytosis and monocyte accumulation in the CNS, only CCL7 deficiency resulted in increased viral burden in the brain and enhanced mortality. The enhanced susceptibility in the absence of CCL7 was associated with the delayed migration of neutrophils and CD8+ T cells into the CNS compared with WT or Ccl2\u2212\/\u2212 mice. To determine whether CCL7 reconstitution could therapeutically alter the survival outcome of WNV infection, we administered exogenous CCL7 i.v. to WNV-infected Ccl7\u2212\/\u2212 mice and observed a significant increase in monocytes and neutrophils, but not CD8+ T cells, within the CNS, as well as an enhancement in survival compared with Ccl7\u2212\/\u2212 mice treated with a linear CCL7 control peptide. Our experiments suggest that CCL7 is an important protective signal involved in leukocyte trafficking during WNV infection, and it may have therapeutic potential for the treatment of acute viral infections of the CNS.<\/jats:p>","DOI":"10.4049\/jimmunol.1500352","type":"journal-article","created":{"date-parts":[[2015,9,23]],"date-time":"2015-09-23T22:23:25Z","timestamp":1443047005000},"page":"4306-4318","source":"Crossref","is-referenced-by-count":98,"title":["Differential Roles of Chemokines CCL2 and CCL7 in Monocytosis and Leukocyte Migration during West Nile Virus Infection"],"prefix":"10.1093","volume":"195","author":[{"given":"Susana V","family":"Bardina","sequence":"first","affiliation":[{"name":"Department of Microbiology, Icahn School of Medicine at Mount Sinai , New York, NY 10029"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Michlmayr","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Icahn School of Medicine at Mount Sinai , New York, NY 10029"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin W","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Icahn School of Medicine at Mount Sinai , New York, NY 10029"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J","family":"Obara","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Sum","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Icahn School of Medicine at Mount Sinai , New York, NY 10029"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israel F","family":"Charo","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute, Department of Medicine, University of California San Francisco , San Francisco, CA 94549"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuyuan","family":"Lu","sequence":"additional","affiliation":[{"name":"Institute of Human Virology, University of Maryland School of Medicine , Baltimore, MD 21201"},{"name":"Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine , Baltimore, MD 21201"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander G","family":"Pletnev","sequence":"additional","affiliation":[{"name":"Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean K","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Icahn School of Medicine at Mount Sinai , New York, NY 10029"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,11,1]]},"reference":[{"key":"2025030704215180800_r1","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1086\/521911","article-title":"The continuing spread of West Nile virus in the western hemisphere","volume":"45","author":"Gubler","year":"2007","journal-title":"Clin. Infect. Dis."},{"key":"2025030704215180800_r2","doi-asserted-by":"crossref","first-page":"611","DOI":"10.3201\/eid0704.017401","article-title":"West Nile virus: a reemerging global pathogen","volume":"7","author":"Petersen","year":"2001","journal-title":"Emerg. Infect. Dis."},{"key":"2025030704215180800_r3","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1084\/jem.20042530","article-title":"Chemokine receptor CCR5 promotes leukocyte trafficking to the brain and survival in West Nile virus infection","volume":"202","author":"Glass","year":"2005","journal-title":"J. Exp. Med."},{"key":"2025030704215180800_r4","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1309\/PU4R76JJMG1F81RP","article-title":"The neuropathology of West Nile virus meningoencephalitis. A report of two cases and review of the literature","volume":"119","author":"Kelley","year":"2003","journal-title":"Am. J. Clin. Pathol."},{"key":"2025030704215180800_r5","doi-asserted-by":"crossref","first-page":"11457","DOI":"10.1128\/JVI.79.17.11457-11466.2005","article-title":"Neuronal CXCL10 directs CD8+ T-cell recruitment and control of West Nile virus encephalitis","volume":"79","author":"Klein","year":"2005","journal-title":"J. Virol."},{"key":"2025030704215180800_r6","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1053\/hp.2000.8047","article-title":"The pathology of human West Nile Virus infection","volume":"31","author":"Sampson","year":"2000","journal-title":"Hum. Pathol."},{"key":"2025030704215180800_r7","doi-asserted-by":"crossref","first-page":"11270","DOI":"10.1073\/pnas.0800898105","article-title":"CXCR4 antagonism increases T cell trafficking in the central nervous system and improves survival from West Nile virus encephalitis","volume":"105","author":"McCandless","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030704215180800_r8","doi-asserted-by":"crossref","first-page":"8312","DOI":"10.1128\/JVI.78.15.8312-8321.2004","article-title":"Role of CD8+ T cells in control of West Nile virus infection","volume":"78","author":"Shrestha","year":"2004","journal-title":"J. Virol."},{"key":"2025030704215180800_r9","doi-asserted-by":"crossref","first-page":"11749","DOI":"10.1128\/JVI.01136-07","article-title":"Fas ligand interactions contribute to CD8+ T-cell-mediated control of West Nile virus infection in the central nervous system","volume":"81","author":"Shrestha","year":"2007","journal-title":"J. Virol."},{"key":"2025030704215180800_r10","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1128\/JVI.80.1.119-129.2006","article-title":"CD8+ T cells require perforin to clear West Nile virus from infected neurons","volume":"80","author":"Shrestha","year":"2006","journal-title":"J. Virol."},{"key":"2025030704215180800_r11","doi-asserted-by":"crossref","first-page":"12060","DOI":"10.1128\/JVI.01650-06","article-title":"CD4+ T-cell responses are required for clearance of West Nile virus from the central nervous system","volume":"80","author":"Sitati","year":"2006","journal-title":"J. Virol."},{"key":"2025030704215180800_r12","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.4049\/jimmunol.180.4.2641","article-title":"CXCR3 mediates region-specific antiviral T cell trafficking within the central nervous system during West Nile virus encephalitis","volume":"180","author":"Zhang","year":"2008","journal-title":"J. Immunol."},{"key":"2025030704215180800_r13","doi-asserted-by":"crossref","first-page":"471","DOI":"10.4049\/jimmunol.1003003","article-title":"Chemokine receptor Ccr2 is critical for monocyte accumulation and survival in West Nile virus encephalitis","volume":"186","author":"Lim","year":"2011","journal-title":"J. Immunol."},{"key":"2025030704215180800_r14","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/BF01718310","article-title":"West Nile virus neuroinvasion and encephalitis induced by macrophage depletion in mice","volume":"141","author":"Ben-Nathan","year":"1996","journal-title":"Arch. Virol."},{"key":"2025030704215180800_r15","doi-asserted-by":"crossref","first-page":"10964","DOI":"10.1128\/JVI.01646-08","article-title":"Early B-cell activation after West Nile virus infection requires alpha\/beta interferon but not antigen receptor signaling","volume":"82","author":"Purtha","year":"2008","journal-title":"J. Virol."},{"key":"2025030704215180800_r16","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1172\/JCI29919","article-title":"Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites","volume":"117","author":"Tsou","year":"2007","journal-title":"J. Clin. Invest."},{"key":"2025030704215180800_r17","doi-asserted-by":"crossref","first-page":"6846","DOI":"10.4049\/jimmunol.180.10.6846","article-title":"Additive roles for MCP-1 and MCP-3 in CCR2-mediated recruitment of inflammatory monocytes during Listeria monocytogenes infection","volume":"180","author":"Jia","year":"2008","journal-title":"J. Immunol."},{"key":"2025030704215180800_r18","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/ni1309","article-title":"Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2","volume":"7","author":"Serbina","year":"2006","journal-title":"Nat. Immunol."},{"key":"2025030704215180800_r19","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1084\/jem.20140488","article-title":"Long-term survival of influenza virus infected club cells drives immunopathology","volume":"211","author":"Heaton","year":"2014","journal-title":"J. Exp. Med."},{"key":"2025030704215180800_r20","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1159\/000321157","article-title":"Organ-specific innate immune responses in a mouse model of invasive candidiasis","volume":"3","author":"Lionakis","year":"2011","journal-title":"J. Innate Immun."},{"key":"2025030704215180800_r21","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1126\/science.7973629","article-title":"Synthesis of proteins by native chemical ligation","volume":"266","author":"Dawson","year":"1994","journal-title":"Science"},{"key":"2025030704215180800_r22","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S0076-6879(97)87005-X","article-title":"Synthesis of chemokines by native chemical ligation","volume":"287","author":"Dawson","year":"1997","journal-title":"Methods Enzymol."},{"key":"2025030704215180800_r23","doi-asserted-by":"crossref","first-page":"37647","DOI":"10.1074\/jbc.M203907200","article-title":"The structure of human macrophage inflammatory protein-3alpha \/CCL20. Linking antimicrobial and CC chemokine receptor-6-binding activities with human beta-defensins","volume":"277","author":"Hoover","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2025030704215180800_r24","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1128\/JVI.77.4.2578-2586.2003","article-title":"B cells and antibody play critical roles in the immediate defense of disseminated infection by West Nile encephalitis virus","volume":"77","author":"Diamond","year":"2003","journal-title":"J. Virol."},{"key":"2025030704215180800_r25","doi-asserted-by":"crossref","first-page":"13323","DOI":"10.1128\/JVI.77.24.13323-13334.2003","article-title":"CD8+ T cells mediate recovery and immunopathology in West Nile virus encephalitis","volume":"77","author":"Wang","year":"2003","journal-title":"J. Virol."},{"key":"2025030704215180800_r26","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1002\/eji.200737192","article-title":"Antigen-specific cytotoxic T lymphocytes protect against lethal West Nile virus encephalitis","volume":"37","author":"Purtha","year":"2007","journal-title":"Eur. J. Immunol."},{"key":"2025030704215180800_r27","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1002\/eji.200737196","article-title":"Protective capacity and epitope specificity of CD8(+) T cells responding to lethal West Nile virus infection","volume":"37","author":"Brien","year":"2007","journal-title":"Eur. J. Immunol."},{"key":"2025030704215180800_r28","doi-asserted-by":"crossref","first-page":"11401","DOI":"10.1128\/JVI.01403-13","article-title":"Pattern recognition receptor MDA5 modulates CD8+ T cell-dependent clearance of West Nile virus from the central nervous system","volume":"87","author":"Lazear","year":"2013","journal-title":"J. Virol."},{"key":"2025030704215180800_r29","doi-asserted-by":"crossref","first-page":"12125","DOI":"10.1128\/JVI.01026-10","article-title":"The innate immune adaptor molecule MyD88 restricts West Nile virus replication and spread in neurons of the central nervous system","volume":"84","author":"Szretter","year":"2010","journal-title":"J. Virol."},{"key":"2025030704215180800_r30","doi-asserted-by":"crossref","first-page":"10349","DOI":"10.1128\/JVI.00935-08","article-title":"Toll-like receptor 3 has a protective role against West Nile virus infection","volume":"82","author":"Daffis","year":"2008","journal-title":"J. Virol."},{"key":"2025030704215180800_r31","doi-asserted-by":"crossref","first-page":"8937","DOI":"10.1128\/JVI.00673-12","article-title":"CD8+ T cells use TRAIL to restrict West Nile virus pathogenesis by controlling infection in neurons","volume":"86","author":"Shrestha","year":"2012","journal-title":"J. Virol."},{"key":"2025030704215180800_r32","doi-asserted-by":"crossref","first-page":"8956","DOI":"10.1128\/JVI.01118-08","article-title":"Tumor necrosis factor alpha protects against lethal West Nile virus infection by promoting trafficking of mononuclear leukocytes into the central nervous system","volume":"82","author":"Shrestha","year":"2008","journal-title":"J. Virol."},{"key":"2025030704215180800_r33","doi-asserted-by":"crossref","first-page":"9801","DOI":"10.1128\/JVI.00941-07","article-title":"CD40-CD40 ligand interactions promote trafficking of CD8+ T cells into the brain and protection against West Nile virus encephalitis","volume":"81","author":"Sitati","year":"2007","journal-title":"J. Virol."},{"key":"2025030704215180800_r34","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1084\/jem.20121897","article-title":"IL-1R1 is required for dendritic cell-mediated T cell reactivation within the CNS during West Nile virus encephalitis","volume":"210","author":"Durrant","year":"2013","journal-title":"J. Exp. Med."},{"key":"2025030704215180800_r35","doi-asserted-by":"crossref","first-page":"3361","DOI":"10.1128\/JVI.02368-12","article-title":"CD22 is required for protection against West Nile virus infection","volume":"87","author":"Ma","year":"2013","journal-title":"J. Virol."},{"key":"2025030704215180800_r36","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.immuni.2012.07.004","article-title":"The RIG-I-like receptor LGP2 controls CD8(+) T cell survival and fitness","volume":"37","author":"Suthar","year":"2012","journal-title":"Immunity"},{"key":"2025030704215180800_r37","doi-asserted-by":"crossref","first-page":"8363","DOI":"10.1128\/JVI.01097-13","article-title":"A role for Ifit2 in restricting West Nile virus infection in the brain","volume":"87","author":"Cho","year":"2013","journal-title":"J. Virol."},{"key":"2025030704215180800_r38","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/j.1750-3639.2007.00080.x","article-title":"Systemic distribution of West Nile virus infection: postmortem immunohistochemical study of six cases","volume":"17","author":"Armah","year":"2007","journal-title":"Brain Pathol."},{"key":"2025030704215180800_r39","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1750-3639.2003.tb00477.x","article-title":"Fatal fulminant pan-meningo-polioencephalitis due to West Nile virus","volume":"13","author":"Omalu","year":"2003","journal-title":"Brain Pathol."},{"key":"2025030704215180800_r40","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/S0002-9440(10)62365-6","article-title":"Central nervous system injury triggers hepatic CC and CXC chemokine expression that is associated with leukocyte mobilization and recruitment to both the central nervous system and the liver","volume":"166","author":"Campbell","year":"2005","journal-title":"Am. J. Pathol."},{"key":"2025030704215180800_r41","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/nm.3108","article-title":"Differential innate immune response programs in neuronal subtypes determine susceptibility to infection in the brain by positive-stranded RNA viruses","volume":"19","author":"Cho","year":"2013","journal-title":"Nat. Med."},{"key":"2025030704215180800_r42","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1186\/1742-2094-9-246","article-title":"Targeted blockade in lethal West Nile virus encephalitis indicates a crucial role for very late antigen (VLA)-4-dependent recruitment of nitric oxide-producing macrophages","volume":"9","author":"Getts","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"2025030704215180800_r43","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.vetimm.2005.10.003","article-title":"Replication of West Nile virus in equine peripheral blood mononuclear cells","volume":"110","author":"Garcia-Tapia","year":"2006","journal-title":"Vet. Immunol. Immunopathol."},{"key":"2025030704215180800_r44","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1086\/657416","article-title":"A paradoxical role for neutrophils in the pathogenesis of West Nile virus","volume":"202","author":"Bai","year":"2010","journal-title":"J. Infect. Dis."},{"key":"2025030704215180800_r45","doi-asserted-by":"crossref","first-page":"e1002865","DOI":"10.1371\/journal.ppat.1002865","article-title":"Chemokine receptor Ccr1 drives neutrophil-mediated kidney immunopathology and mortality in invasive candidiasis","volume":"8","author":"Lionakis","year":"2012","journal-title":"PLoS Pathog."},{"key":"2025030704215180800_r46","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1182\/blood.V94.9.2981","article-title":"Upregulation of integrin alpha6\/beta1 and chemokine receptor CCR1 by interleukin-12 promotes the migration of human type 1 helper T cells","volume":"94","author":"Colantonio","year":"1999","journal-title":"Blood"},{"key":"2025030704215180800_r47","doi-asserted-by":"crossref","first-page":"3840","DOI":"10.4049\/jimmunol.162.7.3840","article-title":"Chemokine receptor responses on T cells are achieved through regulation of both receptor expression and signaling","volume":"162","author":"Rabin","year":"1999","journal-title":"J. Immunol."},{"key":"2025030704215180800_r48","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1016\/S0002-9440(10)64844-4","article-title":"Chemokine receptor 1 knockout abrogates natural killer cell recruitment and impairs type-1 cytokines in lymphoid tissue during pulmonary granuloma formation","volume":"157","author":"Shang","year":"2000","journal-title":"Am. J. Pathol."},{"key":"2025030704215180800_r49","doi-asserted-by":"crossref","first-page":"29671","DOI":"10.1074\/jbc.270.50.29671","article-title":"Monocyte chemoattractant protein-3 is a functional ligand for CC chemokine receptors 1 and 2B","volume":"270","author":"Combadiere","year":"1995","journal-title":"J. Biol. Chem."},{"key":"2025030704215180800_r50","doi-asserted-by":"crossref","first-page":"474","DOI":"10.4049\/jimmunol.162.1.474","article-title":"Up-regulation of CCR1 and CCR3 and induction of chemotaxis to CC chemokines by IFN-gamma in human neutrophils","volume":"162","author":"Bonecchi","year":"1999","journal-title":"J. Immunol."},{"key":"2025030704215180800_r51","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/jlb.60.5.658","article-title":"Preparation of specific polyclonal antibodies to a C-C chemokine receptor, CCR1, and determination of CCR1 expression on various types of leukocytes","volume":"60","author":"Su","year":"1996","journal-title":"J. Leukoc. Biol."},{"key":"2025030704215180800_r52","doi-asserted-by":"crossref","first-page":"4938","DOI":"10.4049\/jimmunol.162.8.4938","article-title":"Differential effects of leukotactin-1 and macrophage inflammatory protein-1 alpha on neutrophils mediated by CCR1","volume":"162","author":"Zhang","year":"1999","journal-title":"J. Immunol."},{"key":"2025030704215180800_r53","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1189\/jlb.0605337","article-title":"Chemokine receptors Ccr1, Ccr2, and Ccr5 mediate neutrophil migration to postischemic tissue","volume":"79","author":"Reichel","year":"2006","journal-title":"J. Leukoc. Biol."},{"key":"2025030704215180800_r54","doi-asserted-by":"crossref","first-page":"10840","DOI":"10.1128\/JVI.01524-14","article-title":"Chemokine (C-C Motif) receptor 1 is required for efficient recruitment of neutrophils during respiratory infection with modified vaccinia virus Ankara","volume":"88","author":"Price","year":"2014","journal-title":"J. Virol."},{"key":"2025030704215180800_r55","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1182\/blood-2006-04-013755","article-title":"G-CSF and AMD3100 mobilize monocytes into the blood that stimulate angiogenesis in vivo through a paracrine mechanism","volume":"108","author":"Capoccia","year":"2006","journal-title":"Blood"},{"key":"2025030704215180800_r56","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3816\/SCT.2004.n.008","article-title":"Leukocytosis and Mobilization of CD34+ Hematopoietic Progenitor Cells by AMD3100, a CXCR4 Antagonist","volume":"1","author":"H\u00fcbel","year":"2004","journal-title":"Support. Cancer Ther."},{"key":"2025030704215180800_r57","doi-asserted-by":"crossref","first-page":"5720","DOI":"10.1182\/blood-2008-08-174946","article-title":"Plerixafor and G-CSF versus placebo and G-CSF to mobilize hematopoietic stem cells for autologous stem cell transplantation in patients with multiple myeloma","volume":"113","author":"DiPersio","year":"2009","journal-title":"Blood"},{"key":"2025030704215180800_r58","doi-asserted-by":"crossref","first-page":"4767","DOI":"10.1200\/JCO.2008.20.7209","article-title":"Phase III prospective randomized double-blind placebo-controlled trial of plerixafor plus granulocyte colony-stimulating factor compared with placebo plus granulocyte colony-stimulating factor for autologous stem-cell mobilization and transplantation for patients with non-Hodgkin\u2019s lymphoma","volume":"27","author":"DiPersio","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"2025030704215180800_r59","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1084\/jem.20080421","article-title":"Ly6c+ \u201cinflammatory monocytes\u201d are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis","volume":"205","author":"Getts","year":"2008","journal-title":"J. Exp. Med."},{"key":"2025030704215180800_r60","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1080\/13550280500384982","article-title":"Differential responses of human brain cells to West Nile virus infection","volume":"11","author":"Cheeran","year":"2005","journal-title":"J. Neurovirol."},{"key":"2025030704215180800_r61","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1099\/vir.0.060558-0","article-title":"Differential induction of CCL5 by pathogenic and non-pathogenic strains of West Nile virus in brain endothelial cells and astrocytes","volume":"95","author":"Hussmann","year":"2014","journal-title":"J. Gen. Virol."},{"key":"2025030704215180800_r62","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/nri3070","article-title":"Monocyte recruitment during infection and inflammation","volume":"11","author":"Shi","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"2025030704215180800_r63","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/B978-0-12-394590-7.00003-8","article-title":"Monocyte-mediated immune defense against murine Listeria monocytogenes infection","volume":"113","author":"Serbina","year":"2012","journal-title":"Adv. Immunol."},{"key":"2025030704215180800_r64","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.immuni.2011.02.016","article-title":"Bone marrow mesenchymal stem and progenitor cells induce monocyte emigration in response to circulating toll-like receptor ligands","volume":"34","author":"Shi","year":"2011","journal-title":"Immunity"},{"key":"2025030704215180800_r65","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1002\/(SICI)1521-4141(199902)29:02<678::AID-IMMU678>3.0.CO;2-J","article-title":"Differential induction of monocyte chemotactic protein-3 in mononuclear leukocytes and fibroblasts by interferon-alpha\/beta and interferon-gamma reveals MCP-3 heterogeneity","volume":"29","author":"Menten","year":"1999","journal-title":"Eur. J. Immunol."},{"key":"2025030704215180800_r66","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.4049\/jimmunol.0900205","article-title":"Regulation of inflammatory monocyte\/macrophage recruitment from the bone marrow during murine cytomegalovirus infection: role for type I interferons in localized induction of CCR2 ligands","volume":"183","author":"Crane","year":"2009","journal-title":"J. Immunol."},{"key":"2025030704215180800_r67","doi-asserted-by":"crossref","first-page":"3940","DOI":"10.4049\/jimmunol.1103053","article-title":"Early induction of CCL7 downstream of TLR9 signaling promotes the development of robust immunity to cryptococcal infection","volume":"188","author":"Qiu","year":"2012","journal-title":"J. Immunol."},{"key":"2025030704215180800_r68","doi-asserted-by":"crossref","first-page":"13350","DOI":"10.1128\/JVI.79.21.13350-13361.2005","article-title":"Alpha\/beta interferon protects against lethal West Nile virus infection by restricting cellular tropism and enhancing neuronal survival","volume":"79","author":"Samuel","year":"2005","journal-title":"J. Virol."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/195\/9\/4306\/62248382\/1500352.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/195\/9\/4306\/62248382\/1500352.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T00:10:19Z","timestamp":1741306219000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/195\/9\/4306\/7973456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,1]]},"references-count":68,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,11,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1500352","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725807057.793513348","asserted-by":"object"}]},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2015,11]]},"published":{"date-parts":[[2015,11,1]]}}}