{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:51:45Z","timestamp":1790754705485,"version":"4.1.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The role of Ab and B cells in preventing infection is established. In contrast, the role of B cell responses in containing chronic infections remains poorly understood. IgG2a (IgG1 in humans) can prevent acute infections, and T-bet promotes IgG2a isotype switching. However, whether IgG2a and B cell\u2013expressed T-bet influence the host\u2013pathogen balance during persisting infections is unclear. We demonstrate that B cell\u2013specific loss of T-bet prevents control of persisting viral infection. T-bet in B cells controlled IgG2a production, as well as mucosal localization, proliferation, glycosylation, and a broad transcriptional program. T-bet controlled a broad antiviral program in addition to IgG2a because T-bet in B cells was important, even in the presence of virus-specific IgG2a. Our data support a model in which T-bet is a universal controller of antiviral immunity across multiple immune lineages.<\/jats:p>","DOI":"10.4049\/jimmunol.1500368","type":"journal-article","created":{"date-parts":[[2016,7,18]],"date-time":"2016-07-18T22:18:35Z","timestamp":1468880315000},"page":"1017-1022","source":"Crossref","is-referenced-by-count":166,"title":["Cutting Edge: B Cell\u2013Intrinsic T-bet Expression Is Required To Control Chronic Viral Infection"],"prefix":"10.1093","volume":"197","author":[{"given":"Burton E","family":"Barnett","sequence":"first","affiliation":[{"name":"Department of Microbiology, University of Pennsylvania Perelman School of Medicine , Philadelphia, PA 19104"},{"name":"Institute for Immunology, University of Pennsylvania Perelman School of Medicine , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan P","family":"Staupe","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Pennsylvania Perelman School of Medicine , Philadelphia, PA 19104"},{"name":"Institute for Immunology, University of Pennsylvania Perelman School of Medicine , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela M","family":"Odorizzi","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Pennsylvania Perelman School of Medicine , Philadelphia, PA 19104"},{"name":"Institute for Immunology, University of Pennsylvania Perelman School of Medicine , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6271-0580","authenticated-orcid":false,"given":"Olesya","family":"Palko","sequence":"additional","affiliation":[{"name":"Institute for Immunology, University of Pennsylvania Perelman School of Medicine , Philadelphia, PA 19104"},{"name":"Division of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vesselin T","family":"Tomov","sequence":"additional","affiliation":[{"name":"Institute for Immunology, University of Pennsylvania Perelman School of Medicine , Philadelphia, PA 19104"},{"name":"Division of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison E","family":"Mahan","sequence":"additional","affiliation":[{"name":"Ragon Institute of MGH, MIT and Harvard , Cambridge, MA 02139"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bronwyn","family":"Gunn","sequence":"additional","affiliation":[{"name":"Ragon Institute of MGH, MIT and Harvard , Cambridge, MA 02139"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Chen","sequence":"additional","affiliation":[{"name":"Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A","family":"Paley","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Pennsylvania Perelman School of Medicine , Philadelphia, PA 19104"},{"name":"Institute for Immunology, University of Pennsylvania Perelman School of Medicine , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galit","family":"Alter","sequence":"additional","affiliation":[{"name":"Ragon Institute of MGH, MIT and Harvard , Cambridge, MA 02139"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1635-8619","authenticated-orcid":false,"given":"Steven L","family":"Reiner","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University , New York, NY 10032"},{"name":"Department of Pediatrics, 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