{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T12:21:39Z","timestamp":1772626899943,"version":"3.50.1"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Akirin2, an evolutionarily conserved nuclear protein, is an important factor regulating inflammatory gene transcription in mammalian innate immune cells by bridging the NF-\u03baB and SWI\/SNF complexes. Although Akirin is critical for Drosophila immune responses, which totally rely on innate immunity, the mammalian NF-\u03baB system is critical not only for the innate but also for the acquired immune system. Therefore, we investigated the role of mouse Akirin2 in acquired immune cells by ablating Akirin2 function in B lymphocytes. B cell\u2013specific Akirin2-deficient (Cd19Cre\/+Akirin2fl\/fl) mice showed profound decrease in the splenic follicular (FO) and peritoneal B-1, but not splenic marginal zone (MZ), B cell numbers. However, both Akirin2-deficient FO and MZ B cells showed severe proliferation defect and are prone to undergo apoptosis in response to TLR ligands, CD40, and BCR stimulation. Furthermore, B cell cycling was defective in the absence of Akirin2 owing to impaired expression of genes encoding cyclin D and c-Myc. Additionally, Brg1 recruitment to the Myc and Ccnd2 promoter was severely impaired in Akirin2-deficient B cells. Cd19Cre\/+Akirin2fl\/fl mice showed impaired in vivo immune responses to T-dependent and -independent Ags. Collectively, these results demonstrate that Akirin2 is critical for the mitogen-induced B cell cycle progression and humoral immune responses by controlling the SWI\/SNF complex, further emphasizing the significant function of Akirin2 not only in the innate, but also in adaptive immune cells.<\/jats:p>","DOI":"10.4049\/jimmunol.1500373","type":"journal-article","created":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T11:15:25Z","timestamp":1433416525000},"page":"519-527","source":"Crossref","is-referenced-by-count":34,"title":["Essential Function for the Nuclear Protein Akirin2 in B Cell Activation and Humoral Immune Responses"],"prefix":"10.1093","volume":"195","author":[{"given":"Sarang","family":"Tartey","sequence":"first","affiliation":[{"name":"Laboratory of Infection and Prevention, Institute for Virus Research, Kyoto University , Kyoto 606-8507 ,","place":["Japan"]},{"name":"Core Research for Engineering, Science, and Technology, Japan Science and Technology Agency , Kyoto 606-8507 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazufumi","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Laboratory of Allergic Diseases, Institute for Advanced Medical Sciences, Hyogo College of Medicine , Hyogo 663-8501 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Imamura","sequence":"additional","affiliation":[{"name":"Laboratory of Infection and Prevention, Institute for Virus Research, Kyoto University , Kyoto 606-8507 ,","place":["Japan"]},{"name":"Core Research for Engineering, Science, and Technology, Japan Science and Technology Agency , Kyoto 606-8507 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuko","family":"Wakabayashi","sequence":"additional","affiliation":[{"name":"Laboratory of Infection and Prevention, Institute for Virus Research, Kyoto University , Kyoto 606-8507 ,","place":["Japan"]},{"name":"Core Research for Engineering, Science, and Technology, Japan Science and Technology Agency , Kyoto 606-8507 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Ori","sequence":"additional","affiliation":[{"name":"Laboratory of Infection and Prevention, Institute for Virus Research, Kyoto University , Kyoto 606-8507 ,","place":["Japan"]},{"name":"Core Research for Engineering, Science, and Technology, Japan Science and Technology Agency , Kyoto 606-8507 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Mino","sequence":"additional","affiliation":[{"name":"Laboratory of Infection and Prevention, Institute for Virus Research, Kyoto University , Kyoto 606-8507 ,","place":["Japan"]},{"name":"Core Research for Engineering, Science, and Technology, Japan Science and Technology Agency , Kyoto 606-8507 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Laboratory of Infection and Prevention, Institute for Virus Research, Kyoto University , Kyoto 606-8507 ,","place":["Japan"]},{"name":"Core Research for Engineering, Science, and Technology, Japan Science and Technology Agency , Kyoto 606-8507 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,7,15]]},"reference":[{"key":"2025030703430987200_r1","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/nri3190","article-title":"Integration of B cell responses through Toll-like receptors and antigen receptors","volume":"12","author":"Rawlings","year":"2012","journal-title":"Nat. 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