{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:03:07Z","timestamp":1790834587121,"version":"4.1.0"},"reference-count":75,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The HuR RNA-binding protein posttranscriptionally controls expression of genes involved in cellular survival, proliferation, and differentiation. To determine roles of HuR in B cell development and function, we analyzed mice with B lineage\u2013specific deletion of the HuR gene. These HuR\u0394\/\u0394 mice have reduced numbers of immature bone marrow and mature splenic B cells, with only the former rescued by p53 inactivation, indicating that HuR supports B lineage cells through developmental stage-specific mechanisms. Upon in vitro activation, HuR\u0394\/\u0394 B cells have a mild proliferation defect and impaired ability to produce mRNAs that encode IgH chains of secreted Abs, but no deficiencies in survival, isotype switching, or expression of germinal center (GC) markers. In contrast, HuR\u0394\/\u0394 mice have minimal serum titers of all Ab isotypes, decreased numbers of GC and plasma B cells, and few peritoneal B-1 B cells. Moreover, HuR\u0394\/\u0394 mice have severely decreased GCs, T follicular helper cells, and high-affinity Abs after immunization with a T cell\u2013dependent Ag. This failure of HuR\u0394\/\u0394 mice to mount a T cell\u2013dependent Ab response contrasts with the ability of HuR\u0394\/\u0394 B cells to become GC-like in vitro, indicating that HuR is essential for aspects of B cell activation unique to the in vivo environment. Consistent with this notion, we find in vitro stimulated HuR\u0394\/\u0394 B cells exhibit modestly reduced surface expression of costimulatory molecules whose expression is similarly decreased in humans with common variable immunodeficiency. HuR\u0394\/\u0394 mice provide a model to identify B cell\u2013intrinsic factors that promote T cell\u2013dependent immune responses in vivo.<\/jats:p>","DOI":"10.4049\/jimmunol.1500512","type":"journal-article","created":{"date-parts":[[2015,8,29]],"date-time":"2015-08-29T00:31:37Z","timestamp":1440808297000},"page":"3449-3462","source":"Crossref","is-referenced-by-count":24,"title":["B Cell\u2013Intrinsic Expression of the HuR RNA-Binding Protein Is Required for the T Cell\u2013Dependent Immune Response In Vivo"],"prefix":"10.1093","volume":"195","author":[{"given":"Amy","family":"DeMicco","sequence":"first","affiliation":[{"name":"Division of Cancer Pathobiology, Department of Pathology and Laboratory Medicine, Center for Childhood Cancer Research, Children\u2019s Hospital of Philadelphia , Philadelphia, PA 19104"},{"name":"Cell and Molecular Biology Graduate Group, Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin S","family":"Naradikian","sequence":"additional","affiliation":[{"name":"Immunology Graduate Group, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104"},{"name":"Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal J","family":"Sindhava","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Je-Hyun","family":"Yoon","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics, National Institute on Aging\u2013Intramural Research Program, National Institutes of Health , Baltimore, MD 21224"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Gorospe","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics, National Institute on Aging\u2013Intramural Research Program, National Institutes of Health , Baltimore, MD 21224"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald B","family":"Wertheim","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Children\u2019s Hospital of Philadelphia , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P","family":"Cancro","sequence":"additional","affiliation":[{"name":"Immunology Graduate Group, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104"},{"name":"Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig H","family":"Bassing","sequence":"additional","affiliation":[{"name":"Division of Cancer Pathobiology, Department of Pathology and Laboratory Medicine, Center for Childhood Cancer Research, Children\u2019s Hospital of Philadelphia , Philadelphia, PA 19104"},{"name":"Cell and Molecular Biology Graduate Group, Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,10,1]]},"reference":[{"key":"2025030704162594500_r1","doi-asserted-by":"crossref","DOI":"10.4061\/2010\/981487","article-title":"Regulation of HuR by DNA damage response kinases","volume":"2010","author":"Kim","year":"2010","journal-title":"J. Nucleic Acids"},{"key":"2025030704162594500_r2","doi-asserted-by":"crossref","first-page":"372","DOI":"10.2174\/138920312801619394","article-title":"Functional interplay between RNA-binding protein HuR and microRNAs","volume":"13","author":"Srikantan","year":"2012","journal-title":"Curr. Protein Pept. Sci."},{"key":"2025030704162594500_r3","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/B978-0-12-394299-9.00006-0","article-title":"An emerging role of RNA-binding proteins as multifunctional regulators of lymphocyte development and function","volume":"115","author":"Turner","year":"2012","journal-title":"Adv. Immunol."},{"key":"2025030704162594500_r4","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3389\/fimmu.2013.00037","article-title":"Roles for BLyS family members in meeting the distinct homeostatic demands of innate and adaptive B cells","volume":"4","author":"Sindhava","year":"2013","journal-title":"Front. Immunol."},{"key":"2025030704162594500_r5","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/nri3570","article-title":"Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signalling","volume":"14","author":"Clark","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"2025030704162594500_r6","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/cmi.2012.63","article-title":"Regulatory functions of innate-like B cells","volume":"10","author":"Zhang","year":"2013","journal-title":"Cell. Mol. Immunol."},{"key":"2025030704162594500_r7","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.smim.2005.02.008","article-title":"Models for peripheral B cell development and homeostasis","volume":"17","author":"Srivastava","year":"2005","journal-title":"Semin. Immunol."},{"key":"2025030704162594500_r8","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/nri3487","article-title":"New insights into pre-BCR and BCR signalling with relevance to B cell malignancies","volume":"13","author":"Rickert","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"2025030704162594500_r9","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/1471-2172-13-63","article-title":"Revisiting the B-cell compartment in mouse and humans: more than one B-cell subset exists in the marginal zone and beyond","volume":"13","author":"Garraud","year":"2012","journal-title":"BMC Immunol."},{"key":"2025030704162594500_r10","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/intimm\/dxq047","article-title":"Finding the right niche: B-cell migration in the early phases of T-dependent antibody responses","volume":"22","author":"Pereira","year":"2010","journal-title":"Int. Immunol."},{"key":"2025030704162594500_r11","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00281-009-0194-z","article-title":"Signals that influence T follicular helper cell differentiation and function","volume":"32","author":"Linterman","year":"2010","journal-title":"Semin. Immunopathol."},{"key":"2025030704162594500_r12","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.immuni.2011.11.001","article-title":"How T cells earn the follicular rite of passage","volume":"35","author":"Vinuesa","year":"2011","journal-title":"Immunity"},{"key":"2025030704162594500_r13","doi-asserted-by":"crossref","first-page":"e17739","DOI":"10.1371\/journal.pone.0017739","article-title":"IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation","volume":"6","author":"Eto","year":"2011","journal-title":"PLoS One"},{"key":"2025030704162594500_r14","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1146\/annurev-immunol-020711-075032","article-title":"Germinal centers","volume":"30","author":"Victora","year":"2012","journal-title":"Annu. Rev. Immunol."},{"key":"2025030704162594500_r15","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/nm.3109","article-title":"Inadequate T follicular cell help impairs B cell immunity during HIV infection","volume":"19","author":"Cubas","year":"2013","journal-title":"Nat. Med."},{"key":"2025030704162594500_r16","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1084\/jem.180.1.157","article-title":"gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory","volume":"180","author":"Foy","year":"1994","journal-title":"J. Exp. Med."},{"key":"2025030704162594500_r17","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/1074-7613(94)90073-6","article-title":"Mice deficient for the CD40 ligand","volume":"1","author":"Xu","year":"1994","journal-title":"Immunity"},{"key":"2025030704162594500_r18","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.1073\/pnas.0306453101","article-title":"Identification of a target RNA motif for RNA-binding protein HuR","volume":"101","author":"L\u00f3pez de Silanes","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030704162594500_r19","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1182\/blood-2010-09-310987","article-title":"ATM regulates a DNA damage response posttranscriptional RNA operon in lymphocytes","volume":"117","author":"Mazan-Mamczarz","year":"2011","journal-title":"Blood"},{"key":"2025030704162594500_r20","doi-asserted-by":"crossref","first-page":"37063","DOI":"10.1074\/jbc.C111.266882","article-title":"Genomic analyses of the RNA-binding protein Hu antigen R (HuR) identify a complex network of target genes and novel characteristics of its binding sites","volume":"286","author":"Uren","year":"2011","journal-title":"J. Biol. Chem."},{"key":"2025030704162594500_r21","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nmeth.1608","article-title":"A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins","volume":"8","author":"Kishore","year":"2011","journal-title":"Nat. Methods"},{"key":"2025030704162594500_r22","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.molcel.2011.06.007","article-title":"Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability","volume":"43","author":"Mukherjee","year":"2011","journal-title":"Mol. Cell"},{"key":"2025030704162594500_r23","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1128\/MCB.01393-08","article-title":"The RNA-binding protein Elavl1\/HuR is essential for placental branching morphogenesis and embryonic development","volume":"29","author":"Katsanou","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"2025030704162594500_r24","doi-asserted-by":"crossref","first-page":"3530","DOI":"10.1172\/JCI38263","article-title":"Essential role of the RNA-binding protein HuR in progenitor cell survival in mice","volume":"119","author":"Ghosh","year":"2009","journal-title":"J. Clin. Invest."},{"key":"2025030704162594500_r25","doi-asserted-by":"crossref","first-page":"13789","DOI":"10.1073\/pnas.0605944103","article-title":"Testing gene function early in the B cell lineage in mb1-cre mice","volume":"103","author":"Hobeika","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030704162594500_r26","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/ng747","article-title":"Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer","volume":"29","author":"Jonkers","year":"2001","journal-title":"Nat. Genet."},{"key":"2025030704162594500_r27","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1084\/jem.20060701","article-title":"Autoreactive marginal zone B cells are spontaneously activated but lymph node B cells require T cell help","volume":"203","author":"Mandik-Nayak","year":"2006","journal-title":"J. Exp. Med."},{"key":"2025030704162594500_r28","doi-asserted-by":"crossref","first-page":"4757","DOI":"10.1038\/onc.2011.191","article-title":"Tp53 deletion in B lineage cells predisposes mice to lymphomas with oncogenic translocations","volume":"30","author":"Rowh","year":"2011","journal-title":"Oncogene"},{"key":"2025030704162594500_r29","doi-asserted-by":"crossref","first-page":"4217","DOI":"10.1093\/emboj\/16.14.4217","article-title":"Normal development but differentially altered proliferative responses of lymphocytes in mice lacking CD81","volume":"16","author":"Miyazaki","year":"1997","journal-title":"EMBO J."},{"key":"2025030704162594500_r30","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0167-4781(99)00131-1","article-title":"Switch recombination and germ-line transcription are division-regulated events in B lymphocytes","volume":"1447","author":"McCall","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"2025030704162594500_r31","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0022-1759(94)90236-4","article-title":"Determination of lymphocyte division by flow cytometry","volume":"171","author":"Lyons","year":"1994","journal-title":"J. Immunol. Methods"},{"key":"2025030704162594500_r32","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.4049\/jimmunol.0903099","article-title":"Posttranscriptional silencing of VbetaDJbetaCbeta genes contributes to TCRbeta allelic exclusion in mammalian lymphocytes","volume":"185","author":"Steinel","year":"2010","journal-title":"J. Immunol."},{"key":"2025030704162594500_r33","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.molcel.2012.06.027","article-title":"LincRNA-p21 suppresses target mRNA translation. [Published erratum appears in 2013 Mol. Cell 50: 303.]","volume":"47","author":"Yoon","year":"2012","journal-title":"Mol. Cell"},{"key":"2025030704162594500_r34","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/nmeth.2518","article-title":"Integrated proteomic analysis of post-translational modifications by serial enrichment","volume":"10","author":"Mertins","year":"2013","journal-title":"Nat. Methods"},{"key":"2025030704162594500_r35","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1084\/jem.173.5.1213","article-title":"Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow","volume":"173","author":"Hardy","year":"1991","journal-title":"J. Exp. Med."},{"key":"2025030704162594500_r36","doi-asserted-by":"crossref","first-page":"5633","DOI":"10.4049\/jimmunol.0802413","article-title":"Direct hematological toxicity and illegitimate chromosomal recombination caused by the systemic activation of CreERT2","volume":"182","author":"Higashi","year":"2009","journal-title":"J. Immunol."},{"key":"2025030704162594500_r37","doi-asserted-by":"crossref","first-page":"e46590","DOI":"10.1371\/journal.pone.0046590","article-title":"Activation kinetics and off-target effects of thymus-initiated cre transgenes","volume":"7","author":"Shi","year":"2012","journal-title":"PLoS One"},{"key":"2025030704162594500_r38","doi-asserted-by":"crossref","first-page":"4431","DOI":"10.4049\/jimmunol.151.9.4431","article-title":"Peripheral B cell maturation. II. Heat-stable antigen(hi) splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells","volume":"151","author":"Allman","year":"1993","journal-title":"J. Immunol."},{"key":"2025030704162594500_r39","doi-asserted-by":"crossref","first-page":"9209","DOI":"10.1073\/pnas.161269798","article-title":"Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells","volume":"98","author":"Loonstra","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030704162594500_r40","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S1097-2765(01)00295-7","article-title":"Self-excising retroviral vectors encoding the Cre recombinase overcome Cre-mediated cellular toxicity","volume":"8","author":"Silver","year":"2001","journal-title":"Mol. Cell"},{"key":"2025030704162594500_r41","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1084\/jem.20041074","article-title":"Immunoglobulin class switch recombination is impaired in Atm-deficient mice","volume":"200","author":"Lumsden","year":"2004","journal-title":"J. Exp. Med."},{"key":"2025030704162594500_r42","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1261\/rna.5820103","article-title":"B-cell and plasma-cell splicing differences: a potential role in regulated immunoglobulin RNA processing","volume":"9","author":"Bruce","year":"2003","journal-title":"RNA"},{"key":"2025030704162594500_r43","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/wrna.36","article-title":"Immunoglobulin heavy chain gene regulation through polyadenylation and splicing competition","volume":"2","author":"Peterson","year":"2011","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"2025030704162594500_r44","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.molcel.2011.06.008","article-title":"Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR","volume":"43","author":"Lebedeva","year":"2011","journal-title":"Mol. Cell"},{"key":"2025030704162594500_r45","doi-asserted-by":"crossref","first-page":"6177","DOI":"10.4049\/jimmunol.0904085","article-title":"p53 represses class switch recombination to IgG2a through its antioxidant function","volume":"184","author":"Guikema","year":"2010","journal-title":"J. Immunol."},{"key":"2025030704162594500_r46","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1084\/jem.20120994","article-title":"The origins, function, and regulation of T follicular helper cells","volume":"209","author":"Ma","year":"2012","journal-title":"J. Exp. Med."},{"key":"2025030704162594500_r47","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/ni1100","article-title":"Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5","volume":"5","author":"Allen","year":"2004","journal-title":"Nat. Immunol."},{"key":"2025030704162594500_r48","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1128\/MCB.00650-10","article-title":"Cyclin D3 is selectively required for proliferative expansion of germinal center B cells","volume":"31","author":"Cato","year":"2011","journal-title":"Mol. Cell. Biol."},{"key":"2025030704162594500_r49","doi-asserted-by":"crossref","first-page":"5021","DOI":"10.1182\/blood-2012-04-424648","article-title":"Splenic proliferative lymphoid nodules distinct from germinal centers are sites of autoantigen stimulation in immune thrombocytopenia","volume":"120","author":"Daridon","year":"2012","journal-title":"Blood"},{"key":"2025030704162594500_r50","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.4049\/jimmunol.1100853","article-title":"Cutting edge: dendritic cell-restricted antigen presentation initiates the follicular helper T cell program but cannot complete ultimate effector differentiation","volume":"187","author":"Goenka","year":"2011","journal-title":"J. Immunol."},{"key":"2025030704162594500_r51","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.immuni.2012.11.020","article-title":"Persistent antigen and germinal center B cells sustain T follicular helper cell responses and phenotype","volume":"38","author":"Baumjohann","year":"2013","journal-title":"Immunity"},{"key":"2025030704162594500_r52","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.coi.2005.04.004","article-title":"CD27 and CD70 in T cell and B cell activation","volume":"17","author":"Borst","year":"2005","journal-title":"Curr. Opin. Immunol."},{"key":"2025030704162594500_r53","doi-asserted-by":"crossref","first-page":"7058","DOI":"10.4049\/jimmunol.162.12.7058","article-title":"CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells","volume":"162","author":"Akiba","year":"1999","journal-title":"J. Immunol."},{"key":"2025030704162594500_r54","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1189\/jlb.0610351","article-title":"Role of CD27\/CD70 pathway of activation in immunity and tolerance","volume":"89","author":"Denoeud","year":"2011","journal-title":"J. Leukoc. Biol."},{"key":"2025030704162594500_r55","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s12026-014-8490-7","article-title":"Function of the tetraspanin molecule CD81 in B and T cells","volume":"58","author":"Levy","year":"2014","journal-title":"Immunol. Res."},{"key":"2025030704162594500_r56","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1084\/jem.185.8.1505","article-title":"Normal lymphocyte development but delayed humoral immune response in CD81-null mice","volume":"185","author":"Maecker","year":"1997","journal-title":"J. Exp. Med."},{"key":"2025030704162594500_r57","doi-asserted-by":"crossref","first-page":"10844","DOI":"10.1073\/pnas.94.20.10844","article-title":"Impaired CD19 expression and signaling, enhanced antibody response to type II T independent antigen and reduction of B-1 cells in CD81-deficient mice","volume":"94","author":"Tsitsikov","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030704162594500_r58","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S1074-7613(00)80333-7","article-title":"B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation","volume":"6","author":"Borriello","year":"1997","journal-title":"Immunity"},{"key":"2025030704162594500_r59","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1172\/JCI39748","article-title":"CD81 gene defect in humans disrupts CD19 complex formation and leads to antibody deficiency","volume":"120","author":"van Zelm","year":"2010","journal-title":"J. Clin. Invest."},{"key":"2025030704162594500_r60","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1046\/j.1365-2249.2002.01883.x","article-title":"Impaired up-regulation of CD70 and CD86 in naive (CD27-) B cells from patients with common variable immunodeficiency (CVID)","volume":"129","author":"Groth","year":"2002","journal-title":"Clin. Exp. Immunol."},{"key":"2025030704162594500_r61","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1002\/(SICI)1521-4141(200004)30:4<1069::AID-IMMU1069>3.0.CO;2-M","article-title":"Impaired up-regulation of CD86 in B cells of \u201ctype A\u201d common variable immunodeficiency patients","volume":"30","author":"Denz","year":"2000","journal-title":"Eur. J. Immunol."},{"key":"2025030704162594500_r62","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/ni.3115","article-title":"The RNA-binding protein HuR is essential for the B cell antibody response","volume":"16","author":"Diaz-Mu\u00f1oz","year":"2015","journal-title":"Nat. Immunol."},{"key":"2025030704162594500_r63","doi-asserted-by":"crossref","first-page":"6779","DOI":"10.4049\/jimmunol.0900377","article-title":"Control of thymic T cell maturation, deletion and egress by the RNA-binding protein HuR","volume":"182","author":"Papadaki","year":"2009","journal-title":"J. Immunol."},{"key":"2025030704162594500_r64","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/ni.2965","article-title":"B cell homeostasis and follicle confines are governed by fibroblastic reticular cells","volume":"15","author":"Cremasco","year":"2014","journal-title":"Nat. Immunol."},{"key":"2025030704162594500_r65","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1084\/jem.20030789","article-title":"Normal B cell homeostasis requires B cell activation factor production by radiation-resistant cells","volume":"198","author":"Gorelik","year":"2003","journal-title":"J. Exp. Med."},{"key":"2025030704162594500_r66","doi-asserted-by":"crossref","first-page":"e5456","DOI":"10.1371\/journal.pone.0005456","article-title":"Crucial role for BAFF-BAFF-R signaling in the survival and maintenance of mature B cells","volume":"4","author":"Rauch","year":"2009","journal-title":"PLoS One"},{"key":"2025030704162594500_r67","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1182\/blood-2013-01-477505","article-title":"Requirement for Rictor in homeostasis and function of mature B lymphoid cells","volume":"122","author":"Lee","year":"2013","journal-title":"Blood"},{"key":"2025030704162594500_r68","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.imlet.2014.01.018","article-title":"APRIL mediates peritoneal B-1 cell homeostasis","volume":"160","author":"Sindhava","year":"2014","journal-title":"Immunol. Lett."},{"key":"2025030704162594500_r69","doi-asserted-by":"crossref","first-page":"16252","DOI":"10.1073\/pnas.1214414109","article-title":"Heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL) and elongation factor, RNA polymerase II, 2 (ELL2) are regulators of mRNA processing in plasma cells","volume":"109","author":"Benson","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030704162594500_r70","doi-asserted-by":"crossref","first-page":"7663","DOI":"10.4049\/jimmunol.179.11.7663","article-title":"Increased phosphorylation of the carboxyl-terminal domain of RNA polymerase II and loading of polyadenylation and cotranscriptional factors contribute to regulation of the Ig heavy chain mRNA in plasma cells","volume":"179","author":"Shell","year":"2007","journal-title":"J. Immunol."},{"key":"2025030704162594500_r71","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1128\/MCB.21.4.1228-1238.2001","article-title":"hnRNP F influences binding of a 64-kilodalton subunit of cleavage stimulation factor to mRNA precursors in mouse B cells","volume":"21","author":"Veraldi","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"2025030704162594500_r72","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/ni907","article-title":"Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1","volume":"4","author":"Iwakoshi","year":"2003","journal-title":"Nat. Immunol."},{"key":"2025030704162594500_r73","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/nri3469","article-title":"How B cells capture, process and present antigens: a crucial role for cell polarity","volume":"13","author":"Yuseff","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"2025030704162594500_r74","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1084\/jem.20111504","article-title":"B and T cells collaborate in antiviral responses via IL-6, IL-21, and transcriptional activator and coactivator, Oct2 and OBF-1","volume":"209","author":"Karnowski","year":"2012","journal-title":"J. Exp. Med."},{"key":"2025030704162594500_r75","doi-asserted-by":"crossref","first-page":"7661","DOI":"10.4049\/jimmunol.0803783","article-title":"B7-1\/2 (CD80\/CD86) direct signaling to B cells enhances IgG secretion","volume":"183","author":"Rau","year":"2009","journal-title":"J. Immunol."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/195\/7\/3449\/62248565\/1500512.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/195\/7\/3449\/62248565\/1500512.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T04:34:03Z","timestamp":1741322043000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/195\/7\/3449\/7973435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,1]]},"references-count":75,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,10,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1500512","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2015,10]]},"published":{"date-parts":[[2015,10,1]]}}}