{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T15:56:08Z","timestamp":1783612568969,"version":"3.55.0"},"reference-count":71,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Tissues accommodate defined numbers of dendritic cells (DCs) in highly specific niches where different intrinsic and environmental stimuli control DC life span and numbers. DC homeostasis in tissues is important, because experimental changes in DC numbers influence immunity and tolerance toward various immune catastrophes and inflammation. However, the precise molecular mechanisms regulating DC life span and homeostasis are unclear. We report that the GTPase RhoA controls homeostatic proliferation, cytokinesis, survival, and turnover of cDCs. Deletion of RhoA strongly decreased the numbers of CD11b\u2212CD8+ and CD11b+Esamhi DC subsets, whereas CD11b+Esamlo DCs were not affected in conditional RhoA-deficient mice. Proteome analyses revealed a defective prosurvival pathway via PI3K\/protein kinase B (Akt1)\/Bcl-2\u2013associated death promoter in the absence of RhoA. Taken together, our findings identify RhoA as a central regulator of DC homeostasis, and its deletion decreases DC numbers below critical thresholds for immune protection and homeostasis, causing aberrant compensatory DC proliferation.<\/jats:p>","DOI":"10.4049\/jimmunol.1500676","type":"journal-article","created":{"date-parts":[[2015,9,26]],"date-time":"2015-09-26T00:28:35Z","timestamp":1443227315000},"page":"4244-4256","source":"Crossref","is-referenced-by-count":6,"title":["Control of Homeostasis and Dendritic Cell Survival by the GTPase RhoA"],"prefix":"10.1093","volume":"195","author":[{"given":"Shuai","family":"Li","sequence":"first","affiliation":[{"name":"Institute for Immunology, Ludwig-Maximilians-University , 80336 Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bastian","family":"Dislich","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases , 81377 Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cord H","family":"Brakebusch","sequence":"additional","affiliation":[{"name":"Biotech Research and Innovation Center, Molecular Pathology Section , 2200 Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan F","family":"Lichtenthaler","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases , 81377 Munich ,","place":["Germany"]},{"name":"Neuroproteomics, Technical University Munich , 81675 Munich ,","place":["Germany"]},{"name":"Munich Cluster for Systems Neurology , 81377 Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Brocker","sequence":"additional","affiliation":[{"name":"Institute for Immunology, Ludwig-Maximilians-University , 80336 Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,11,1]]},"reference":[{"key":"2025030704195743700_r1","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1146\/annurev.immunol.21.120601.141040","article-title":"Tolerogenic dendritic cells","volume":"21","author":"Steinman","year":"2003","journal-title":"Annu. 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