{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:31:15Z","timestamp":1789756275858,"version":"4.0.1"},"reference-count":78,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Preterm birth (PTB) is firmly linked to inflammation regardless of the presence of infection. Proinflammatory cytokines, including IL-1\u03b2, are produced in gestational tissues and can locally upregulate uterine activation proteins. Premature activation of the uterus by inflammation may lead to PTB, and IL-1 has been identified as a key inducer of this condition. However, all currently available IL-1 inhibitors are large molecules that exhibit competitive antagonism properties by inhibiting all IL-1R signaling, including transcription factor NF-\u03baB, which conveys important physiological roles. We hereby demonstrate the efficacy of a small noncompetitive (all-d peptide) IL-1R\u2013biased ligand, termed rytvela (labeled 101.10) in delaying IL-1\u03b2\u2013, TLR2-, and TLR4-induced PTB in mice. The 101.10 acts without significant inhibition of NF-\u03baB, and instead selectively inhibits IL-1R downstream stress-associated protein kinases\/transcription factor c-jun and Rho GTPase\/Rho-associated coiled-coil\u2013containing protein kinase signaling pathways. The 101.10 is effective at decreasing proinflammatory and\/or prolabor genes in myometrium tissue and circulating leukocytes in all PTB models independently of NF-\u03baB, undermining NF-\u03baB role in preterm labor. In this work, biased signaling modulation of IL-1R by 101.10 uncovers a novel strategy to prevent PTB without inhibiting NF-\u03baB.<\/jats:p>","DOI":"10.4049\/jimmunol.1500758","type":"journal-article","created":{"date-parts":[[2015,8,24]],"date-time":"2015-08-24T21:33:55Z","timestamp":1440452035000},"page":"3402-3415","source":"Crossref","is-referenced-by-count":112,"title":["Novel Noncompetitive IL-1 Receptor\u2013Biased Ligand Prevents Infection- and Inflammation-Induced Preterm Birth"],"prefix":"10.1093","volume":"195","author":[{"given":"Mathieu","family":"Nadeau-Vall\u00e9e","sequence":"first","affiliation":[{"name":"Department of Pediatrics, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1C5 ,","place":["Canada"]},{"name":"Department of Ophthalmology, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1C5 ,","place":["Canada"]},{"name":"Department of Pharmacology, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1C5 ,","place":["Canada"]},{"name":"Department of Pharmacology, University of Montreal , Montreal, Quebec H3C 3J7 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Quiniou","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1C5 ,","place":["Canada"]},{"name":"Department of Ophthalmology, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1C5 ,","place":["Canada"]},{"name":"Department of Pharmacology, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1C5 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Palacios","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1C5 ,","place":["Canada"]},{"name":"Department of Ophthalmology, CHU Sainte-Justine Research Center , Montreal, Quebec H3T 1C5 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Chem."},{"key":"2025030704151747300_r62","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0945-053X(97)90026-3","article-title":"The AP-1 site and MMP gene regulation: what is all the fuss about?","volume":"15","author":"Benbow","year":"1997","journal-title":"Matrix Biol."},{"key":"2025030704151747300_r63","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1210\/en.2004-1066","article-title":"Differential activation of the connexin 43 promoter by dimers of activator protein-1 transcription factors in myometrial cells","volume":"146","author":"Mitchell","year":"2005","journal-title":"Endocrinology"},{"key":"2025030704151747300_r64","doi-asserted-by":"crossref","first-page":"23667","DOI":"10.1074\/jbc.271.39.23667","article-title":"Activation of protein kinase C in human uterine smooth muscle induces connexin-43 gene transcription through an AP-1 site in the promoter sequence","volume":"271","author":"Geimonen","year":"1996","journal-title":"J. Biol. 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Obstet. Gynecol."},{"key":"2025030704151747300_r68","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/j.1600-0897.2010.00891.x","article-title":"Toll-like receptor-2 and Toll-like receptor-4 expression on maternal neutrophils during pregnancy","volume":"64","author":"Nitsche","year":"2010","journal-title":"Am. J. Reprod. Immunol."},{"key":"2025030704151747300_r69","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1095\/biolreprod.108.069252","article-title":"Expression and activity of Toll-like receptors 1-9 in the human term placenta and changes associated with labor at term","volume":"80","author":"Patni","year":"2009","journal-title":"Biol. 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