{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T04:32:50Z","timestamp":1776400370672,"version":"3.51.2"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The role of the nucleotide-binding domain and leucine-rich repeat containing receptor NLRP10 in disease is incompletely understood. Using three mouse strains lacking the gene encoding NLRP10, only one of which had a coincidental mutation in DOCK8, we documented a role for NLRP10 as a suppressor of the cutaneous inflammatory response to Leishmania major infection. There was no evidence that the enhanced local inflammation was due to enhanced inflammasome activity. NLRP10\/DOCK8-deficient mice harbored lower parasite burdens at the cutaneous site of inoculation compared with wild-type controls, whereas NLRP10-deficient mice and controls had similar parasite loads, suggesting that DOCK8 promotes local growth of parasites in the skin, whereas NLRP10 does not. NLRP10-deficient mice developed vigorous adaptive immune responses, indicating that there was not a global defect in the development of Ag-specific cytokine production. Bone marrow chimeras showed that the anti-inflammatory role of NLRP10 was mediated by NLRP10 expressed in resident cells in the skin rather than by bone marrow\u2013derived cells. These data suggest a novel role for NLRP10 in the resolution of local inflammatory responses during L. major infection.<\/jats:p>","DOI":"10.4049\/jimmunol.1500832","type":"journal-article","created":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T00:25:35Z","timestamp":1505953535000},"page":"2823-2833","source":"Crossref","is-referenced-by-count":28,"title":["An Anti-Inflammatory Role for NLRP10 in Murine Cutaneous Leishmaniasis"],"prefix":"10.1093","volume":"199","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8218-7646","authenticated-orcid":false,"given":"Gwendolyn M","family":"Clay","sequence":"first","affiliation":[{"name":"Interdisciplinary Program in Molecular and Cellular Biology, University of Iowa , Iowa City, IA 52242"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0432-4777","authenticated-orcid":false,"given":"Diogo G","family":"Valadares","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Iowa , Iowa City, IA 52242"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel W","family":"Graff","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Iowa , Iowa City, IA 52242"},{"name":"Veterans Affairs Medical Center , Iowa City, IA 52246"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tyler K","family":"Ulland","sequence":"additional","affiliation":[{"name":"Interdisciplinary Program in Molecular and Cellular Biology, University of Iowa , Iowa City, IA 52242"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard E","family":"Davis","sequence":"additional","affiliation":[{"name":"Interdisciplinary Program in Immunology, University of Iowa , Iowa City, IA 52242"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Breanna M","family":"Scorza","sequence":"additional","affiliation":[{"name":"Interdisciplinary Program in Immunology, University of Iowa , Iowa City, IA 52242"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bayan Sudan","family":"Zhanbolat","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Iowa , Iowa City, IA 52242"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yani","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Iowa , Iowa City, IA 52242"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fayyaz S","family":"Sutterwala","sequence":"additional","affiliation":[{"name":"Interdisciplinary Program in Molecular and Cellular Biology, University of Iowa , Iowa City, IA 52242"},{"name":"Department of Internal Medicine, University of Iowa , Iowa City, IA 52242"},{"name":"Interdisciplinary Program in Immunology, University of Iowa , Iowa City, IA 52242"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary E","family":"Wilson","sequence":"additional","affiliation":[{"name":"Interdisciplinary Program in Molecular and Cellular Biology, University of Iowa , Iowa City, IA 52242"},{"name":"Department of Internal Medicine, University of Iowa , Iowa City, IA 52242"},{"name":"Veterans Affairs Medical Center , Iowa City, IA 52246"},{"name":"Interdisciplinary Program in Immunology, University of Iowa , Iowa City, IA 52242"},{"name":"Department of Microbiology, University of Iowa , Iowa City, IA 52242"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,10,15]]},"reference":[{"key":"2025030614482840900_r1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nature11250","article-title":"NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens","volume":"488","author":"Anand","year":"2012","journal-title":"Nature"},{"key":"2025030614482840900_r2","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.immuni.2012.03.012","article-title":"NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-\u03baB signaling","volume":"36","author":"Allen","year":"2012","journal-title":"Immunity"},{"key":"2025030614482840900_r3","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1128\/MCB.01468-07","article-title":"ATP binding by monarch-1\/NLRP12 is critical for its inhibitory function","volume":"28","author":"Ye","year":"2008","journal-title":"Mol. 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