{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:39:04Z","timestamp":1791247144619,"version":"4.1.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Differences in the quality of BCR signaling control key steps of B cell maturation and differentiation. Endogenously produced H2O2 is thought to fine tune the level of BCR signaling by reversibly inhibiting phosphatases. However, relatively little is known about how B cells at different stages sense and respond to such redox cues. In this study, we used phospho-specific flow cytometry and high-dimensional mass cytometry (CyTOF) to compare BCR signaling responses in mature human tonsillar B cells undergoing germinal center (GC) reactions. GC B cells, in contrast to mature naive B cells, memory B cells, and plasmablasts, were hypersensitive to a range of H2O2 concentrations and responded by phosphorylating SYK and other membrane-proximal BCR effectors in the absence of BCR engagement. These findings reveal that stage-specific redox responses distinguish human GC B cells.<\/jats:p>","DOI":"10.4049\/jimmunol.1500904","type":"journal-article","created":{"date-parts":[[2015,7,9]],"date-time":"2015-07-09T01:56:04Z","timestamp":1436406964000},"page":"1364-1367","source":"Crossref","is-referenced-by-count":37,"title":["Cutting Edge: Redox Signaling Hypersensitivity Distinguishes Human Germinal Center B Cells"],"prefix":"10.1093","volume":"195","author":[{"given":"Hannah G","family":"Polikowsky","sequence":"first","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center , Nashville, TN 37232"},{"name":"Cancer Biology, Vanderbilt\u2013Ingram Cancer Center, Vanderbilt University Medical Center , Nashville, TN 37232"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cara E","family":"Wogsland","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center , Nashville, TN 37232"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten E","family":"Diggins","sequence":"additional","affiliation":[{"name":"Cancer Biology, Vanderbilt\u2013Ingram Cancer Center, Vanderbilt University Medical Center , Nashville, TN 37232"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanutte","family":"Huse","sequence":"additional","affiliation":[{"name":"Centre for Cancer Biomedicine, University of Oslo , N-0424 Oslo ,","place":["Norway"]},{"name":"Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital , N-0424 Oslo ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9428-8866","authenticated-orcid":false,"given":"Jonathan M","family":"Irish","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center , Nashville, TN 37232"},{"name":"Cancer Biology, Vanderbilt\u2013Ingram Cancer Center, Vanderbilt University Medical Center , Nashville, TN 37232"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,8,15]]},"reference":[{"key":"2025030704044151000_r1","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1038\/ni1202-1129","article-title":"Hydrogen peroxide as second messenger in lymphocyte activation","volume":"3","author":"Reth","year":"2002","journal-title":"Nat. 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