{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:59:28Z","timestamp":1792594768210,"version":"4.5.0"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The abnormal immune response accompanying IgG4-related autoimmune pancreatitis (AIP) is presently unclear. In this study, we examined the role of plasmacytoid dendritic cell (pDC) activation and IFN-\u03b1 production in this disease as well as in a murine model of AIP (MRL\/Mp mice treated with polyinosinic-polycytidylic acid). We found that the development of AIP in treated MRL\/Mp mice occurred in parallel with pancreatic accumulation of pDCs producing IFN-\u03b1, and with pDC depletion and IFN-\u03b1-blocking studies, we showed that such accumulation was necessary for AIP induction. In addition, we found that the pancreas of treated MRL\/Mp mice contained neutrophil extracellular traps (NETs) shown previously to stimulate pDCs to produce IFN-\u03b1. Consistent with these findings, we found that patients with IgG4-related AIP also exhibited pancreatic tissue localization of IFN-\u03b1\u2013expressing pDCs and had significantly higher serum IFN-\u03b1 levels than healthy controls. In addition, the inflamed pancreas of these patients but not controls also contained NETs that were shown to be capable of pDC activation. More importantly, patient pDCs cultured in the presence of NETs produced greatly increased levels of IFN-\u03b1 and induced control B cells to produce IgG4 (but not IgG1) as compared with control pDCs. These data suggest that pDC activation and production of IFN-\u03b1 is a major cause of murine AIP; in addition, the increased pDC production of IFN-\u03b1 and its relation to IgG4 production observed in IgG4-related AIP suggest that this mechanism also plays a role in the human disease.<\/jats:p>","DOI":"10.4049\/jimmunol.1500971","type":"journal-article","created":{"date-parts":[[2015,8,22]],"date-time":"2015-08-22T01:19:38Z","timestamp":1440206378000},"page":"3033-3044","source":"Crossref","is-referenced-by-count":86,"title":["Plasmacytoid Dendritic Cell Activation and IFN-\u03b1 Production Are Prominent Features of Murine Autoimmune Pancreatitis and Human IgG4-Related Autoimmune Pancreatitis"],"prefix":"10.1093","volume":"195","author":[{"given":"Yasuyuki","family":"Arai","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University , Kyoto 606-8507 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouhei","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University , Kyoto 606-8507 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsutoshi","family":"Kuriyama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University , Kyoto 606-8507 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Shiokawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University , Kyoto 606-8507 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzo","family":"Kodama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology 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Hepatology, Kansai Medical University , Osaka 573-1191 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren","family":"Strober","sequence":"additional","affiliation":[{"name":"Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Chiba","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University , Kyoto 606-8507 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University , Kyoto 606-8507 ,","place":["Japan"]},{"name":"Mucosal Immunity Section, Laboratory of Host Defenses, National 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