{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:52:03Z","timestamp":1758397923376,"version":"3.38.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Animal models have enhanced our understanding of the pathogenesis of autoimmune diseases. For these models, genetically identical, inbred mice have commonly been used. Different inbred mouse strains, however, show a high variability in disease manifestation. Identifying the factors that influence this disease variability could provide unrecognized insights into pathogenesis. We established a novel Ab transfer-induced model of epidermolysis bullosa acquisita (EBA), an autoimmune disease characterized by (muco)-cutaneous blistering caused by anti-type VII collagen (COL7) autoantibodies. Blistering after anti-COL7 IgG (directed against the von Willebrand factor A\u2013like domain 2) transfer showed clear variability among inbred mouse strains, that is, severe cutaneous blistering and inflammation in C57BL\/6J and absence of skin lesions in MRL\/MpJ mice. The transfer of anti-COL7 IgG into irradiated, EBA-resistant MRL\/MpJ mice, rescued by transplantation with bone marrow from EBA-susceptible B6.AK-H2k mice, induced blistering. To the contrary, irradiated EBA-susceptible B6.AK-H2k mice that were rescued using MRL\/MpJ bone marrow were devoid of blistering. In vitro, immune complex activation of neutrophils from C57BL\/6J or MRL\/MpJ mice showed an impaired reactive oxygen species release from the latter, whereas no differences were observed after PMA activation. This finding was paralleled by divergent expression profiles of immune complex\u2013activated neutrophils from either C57BL\/6J or MRL\/MpJ mice. Collectively, we demonstrate that radiosensitive cells determine the varying extent of skin inflammation and blistering in the end-stage effector phase of EBA.<\/jats:p>","DOI":"10.4049\/jimmunol.1501003","type":"journal-article","created":{"date-parts":[[2015,7,23]],"date-time":"2015-07-23T01:59:44Z","timestamp":1437616784000},"page":"1945-1954","source":"Crossref","is-referenced-by-count":24,"title":["Radiosensitive Hematopoietic Cells Determine the Extent of Skin Inflammation in Experimental Epidermolysis Bullosa Acquisita"],"prefix":"10.1093","volume":"195","author":[{"given":"Hiroaki","family":"Iwata","sequence":"first","affiliation":[{"name":"Department of Dermatology, University of L\u00fcbeck , D-23538 L\u00fcbeck ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mareike","family":"Witte","sequence":"additional","affiliation":[{"name":"L\u00fcbeck Institute of Experimental Dermatology, University of L\u00fcbeck , D-23538 L\u00fcbeck ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Unni Krishna S R L","family":"Samavedam","sequence":"additional","affiliation":[{"name":"L\u00fcbeck Institute of Experimental Dermatology, University of L\u00fcbeck , D-23538 L\u00fcbeck ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yask","family":"Gupta","sequence":"additional","affiliation":[{"name":"L\u00fcbeck Institute of Experimental Dermatology, University of L\u00fcbeck , D-23538 L\u00fcbeck ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Shimizu","sequence":"additional","affiliation":[{"name":"First Department of Dermatology, School of Medicine, Faculty of Medicine Toho University , Tokyo 143-8540 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Ishiko","sequence":"additional","affiliation":[{"name":"First Department of Dermatology, School of Medicine, Faculty of Medicine Toho University , Tokyo 143-8540 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Schr\u00f6der","sequence":"additional","affiliation":[{"name":"L\u00fcbeck Institute of Experimental Dermatology, University of L\u00fcbeck , D-23538 L\u00fcbeck ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karsten","family":"Seeger","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of L\u00fcbeck , D-23538 L\u00fcbeck ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Dahlke","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of L\u00fcbeck , D-23538 L\u00fcbeck ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Rades","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of L\u00fcbeck , D-23538 L\u00fcbeck ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Detlef","family":"Zillikens","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of L\u00fcbeck , D-23538 L\u00fcbeck ,","place":["Germany"]},{"name":"L\u00fcbeck Institute of Experimental Dermatology, University of L\u00fcbeck , D-23538 L\u00fcbeck ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf J","family":"Ludwig","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of L\u00fcbeck , D-23538 L\u00fcbeck ,","place":["Germany"]},{"name":"L\u00fcbeck Institute of Experimental Dermatology, University of L\u00fcbeck , D-23538 L\u00fcbeck ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,9,1]]},"reference":[{"key":"2025030704065201700_r1","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1056\/NEJMra020100","article-title":"The effect of infections on susceptibility to autoimmune and allergic diseases","volume":"347","author":"Bach","year":"2002","journal-title":"N. 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