{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:20:10Z","timestamp":1789611610984,"version":"build-2803163510"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Streptococci are common human colonizers with a species-specific mucocutaneous distribution. At the same time, they are among the most important and most virulent invasive bacterial pathogens. Thus, site-specific cellular innate immunity, which is predominantly executed by resident and invading myeloid cells, has to be adapted with respect to streptococcal sensing, handling, and response. In this article, we show that TLR13 is the critical mouse macrophage (M\u03a6) receptor in the response to group B Streptococcus, both in bone marrow\u2013derived M\u03a6s and in mature tissue M\u03a6s, such as those residing in the lamina propria of the colon and the dermis, as well as in microglia. In contrast, TLR13 and its chaperone UNC-93B are dispensable for a potent cytokine response of blood monocytes to group B Streptococcus, although monocytes serve as the key progenitors of intestinal and dermal M\u03a6s. Furthermore, a specific role for TLR13 with respect to M\u03a6 function is supported by the response to staphylococci, where TLR13 and UNC-93B limit the cytokine response in bone marrow\u2013derived M\u03a6s and microglia, but not in dermal M\u03a6s. In summary, TLR13 is a critical and site-specific receptor in the single M\u03a6 response to \u03b2-hemolytic streptococci.<\/jats:p>","DOI":"10.4049\/jimmunol.1501014","type":"journal-article","created":{"date-parts":[[2016,2,13]],"date-time":"2016-02-13T12:18:41Z","timestamp":1455365921000},"page":"2733-2741","source":"Crossref","is-referenced-by-count":25,"title":["Streptococci Engage TLR13 on Myeloid Cells in a Site-Specific Fashion"],"prefix":"10.1093","volume":"196","author":[{"given":"Julia","family":"Kolter","sequence":"first","affiliation":[{"name":"Center for Chronic Immunodeficiency, Medical Center, University of Freiburg , 79106 Freiburg ,","place":["Germany"]},{"name":"Faculty of Biology, University of Freiburg , 79104 Freiburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhild","family":"Feuerstein","sequence":"additional","affiliation":[{"name":"Center for Chronic Immunodeficiency, Medical Center, University of Freiburg , 79106 Freiburg ,","place":["Germany"]},{"name":"Faculty of Biology, University of Freiburg , 79104 Freiburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyne","family":"Spoeri","sequence":"additional","affiliation":[{"name":"Center for Chronic Immunodeficiency, Medical Center, University of Freiburg , 79106 Freiburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kourosh","family":"Gharun","sequence":"additional","affiliation":[{"name":"Center for Chronic Immunodeficiency, Medical Center, University of Freiburg , 79106 Freiburg ,","place":["Germany"]},{"name":"Faculty of Biology, University of Freiburg , 79104 Freiburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Elling","sequence":"additional","affiliation":[{"name":"Center for Chronic Immunodeficiency, Medical Center, University of Freiburg , 79106 Freiburg ,","place":["Germany"]},{"name":"Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School , Worcester, MA 01655"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Trieu-Cuot","sequence":"additional","affiliation":[{"name":"Institute Pasteur, Unit\u00e9 de Biologie des Bact\u00e9ries Pathog\u00e8nes \u00e0 Gram-Positif, CNRS ERL3526 , 75724 Paris Cedex 15 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Goldmann","sequence":"additional","affiliation":[{"name":"Institute of Neuropathology, Medical Center, University of Freiburg , 79106 Freiburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Waskow","sequence":"additional","affiliation":[{"name":"Regeneration in Hematopoiesis and Animal Models of Hematopoiesis, Faculty of Medicine, Technical University , 01307 Dresden ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijian J","family":"Chen","sequence":"additional","affiliation":[{"name":"Southwestern Medical School, University of Texas , Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten J","family":"Kirschning","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, Medical Center, University of Essen , 45147 Essen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin D","family":"Deshmukh","sequence":"additional","affiliation":[{"name":"Center for Chronic Immunodeficiency, Medical Center, University of Freiburg , 79106 Freiburg ,","place":["Germany"]},{"name":"Center for Sepsis Control and Care, Medical Center, University of Jena , 07747 Jena ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Henneke","sequence":"additional","affiliation":[{"name":"Center for Chronic Immunodeficiency, Medical Center, University of Freiburg , 79106 Freiburg ,","place":["Germany"]},{"name":"Center for Pediatrics and Adolescent Medicine, Medical Center, University of Freiburg , 79106 Freiburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,3,15]]},"reference":[{"key":"2025030702144967200_r1","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen recognition and innate immunity","volume":"124","author":"Akira","year":"2006","journal-title":"Cell"},{"key":"2025030702144967200_r2","doi-asserted-by":"crossref","first-page":"519","DOI":"10.3389\/fimmu.2014.00519","article-title":"Interaction of Streptococcus agalactiae and Cellular Innate Immunity in Colonization and Disease","volume":"5","author":"Landwehr-Kenzel","year":"2014","journal-title":"Front. 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