{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:23:43Z","timestamp":1790421823616,"version":"4.1.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Intracellular infections, such as those caused by the protozoan parasite Leishmania donovani, a causative agent of visceral leishmaniasis (VL), require a potent host proinflammatory response for control. IL-17 has emerged as an important proinflammatory cytokine required for limiting growth of both extracellular and intracellular pathogens. However, there are conflicting reports on the exact roles for IL-17 during parasitic infections and limited knowledge about cellular sources and the immune pathways it modulates. We examined the role of IL-17 in an experimental model of VL caused by infection of C57BL\/6 mice with L. donovani and identified an early suppressive role for IL-17 in the liver that limited control of parasite growth. IL-17\u2013producing \u03b3\u03b4 T cells recruited to the liver in the first week of infection were the critical source of IL-17 in this model, and CCR2+ inflammatory monocytes were an important target for the suppressive effects of IL-17. Improved parasite control was independent of NO generation, but associated with maintenance of superoxide dismutase mRNA expression in the absence of IL-17 in the liver. Thus, we have identified a novel inhibitory function for IL-17 in parasitic infection, and our results demonstrate important interactions among \u03b3\u03b4 T cells, monocytes, and infected macrophages in the liver that can determine the outcome of parasitic infection.<\/jats:p>","DOI":"10.4049\/jimmunol.1501046","type":"journal-article","created":{"date-parts":[[2015,11,5]],"date-time":"2015-11-05T04:00:06Z","timestamp":1446696006000},"page":"5707-5717","source":"Crossref","is-referenced-by-count":33,"title":["IL-17A\u2013Producing \u03b3\u03b4 T Cells Suppress Early Control of Parasite Growth by Monocytes in the Liver"],"prefix":"10.1093","volume":"195","author":[{"given":"Meru","family":"Sheel","sequence":"first","affiliation":[{"name":"QIMR Berghofer Medical Research Institute , Brisbane, Queensland 4006 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynette","family":"Beattie","sequence":"additional","affiliation":[{"name":"QIMR Berghofer 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