{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:22:32Z","timestamp":1791256952904,"version":"4.1.0"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Promising immunotherapeutic strategies are emerging to restore tolerance in autoimmune diseases by triggering an increase in the number and\/or the function of endogenous regulatory T (Treg) cells, which actively control pathological immune responses. Evidence suggests a remarkable heterogeneity in peripheral Treg cells that warrants their better characterization in terms of phenotype and suppressive function, to determine which subset may be optimally suitable for a given clinical situation. We found that repetitive injections of immature dendritic cells expanded Foxp3-negative CD49b+ Treg cells that displayed an effector memory phenotype. These expanded Treg cells were isolated ex vivo for transcriptome analysis and found to contain multiple transcripts of the canonical Treg signature shared mainly by CD25+ but also by other subphenotypes. We characterized the CD49b+ Treg cell phenotype, underscoring its similarities with the CD25+ Treg cell phenotype and highlighting some differential expression patterns for several markers, including lymphocyte activation gene 3, KLRG1, CD103, ICOS, CTLA-4, and granzyme B. Comparison of the CD25+ and CD49b+ Treg cells' suppressive mechanisms, in vitro and in vivo, revealed the latter's potent suppressive activity, which was partly dependent on IL-10 secretion. Altogether, our results strongly suggest that expression of several canonical Treg cell markers and suppressive function could be Foxp3 independent, and underscore the therapeutic potential of IL-10\u2013secreting CD49b+ Treg cells in arthritis.<\/jats:p>","DOI":"10.4049\/jimmunol.1501069","type":"journal-article","created":{"date-parts":[[2015,11,21]],"date-time":"2015-11-21T04:03:50Z","timestamp":1448078630000},"page":"298-309","source":"Crossref","is-referenced-by-count":19,"title":["Nonclassical CD4+CD49b+ Regulatory T Cells as a Better Alternative to Conventional CD4+CD25+ T Cells To Dampen Arthritis Severity"],"prefix":"10.1093","volume":"196","author":[{"given":"Rita","family":"Vicente","sequence":"first","affiliation":[{"name":"INSERM U1183, Institute of Regenerative Medicine and Biotherapies , 34295 Montpellier ,","place":["France"]},{"name":"University of Montpellier , 34095 Montpellier ,","place":["France"]},{"name":"Centre Hospitalier Universitaire Saint Eloi, Institute of Regenerative Medicine and Biotherapies , 34295 Montpellier ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Quentin","sequence":"additional","affiliation":[{"name":"INSERM U1183, Institute of Regenerative Medicine and Biotherapies , 34295 Montpellier ,","place":["France"]},{"name":"University of Montpellier , 34095 Montpellier ,","place":["France"]},{"name":"Centre Hospitalier Universitaire Saint Eloi, Institute of Regenerative Medicine and Biotherapies , 34295 Montpellier ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Laure","family":"Mausset-Bonnefont","sequence":"additional","affiliation":[{"name":"INSERM U1183, Institute of Regenerative Medicine and Biotherapies , 34295 Montpellier ,","place":["France"]},{"name":"University of Montpellier , 34095 Montpellier ,","place":["France"]},{"name":"Centre Hospitalier Universitaire Saint Eloi, Institute of Regenerative Medicine and Biotherapies , 34295 Montpellier ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Chuchana","sequence":"additional","affiliation":[{"name":"INSERM U1183, Institute of Regenerative Medicine and Biotherapies , 34295 Montpellier ,","place":["France"]},{"name":"University of Montpellier , 34095 Montpellier ,","place":["France"]},{"name":"Centre Hospitalier Universitaire Saint Eloi, Institute of Regenerative Medicine and Biotherapies , 34295 Montpellier ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Martire","sequence":"additional","affiliation":[{"name":"INSERM U1183, Institute of Regenerative Medicine and Biotherapies , 34295 Montpellier ,","place":["France"]},{"name":"University of Montpellier , 34095 Montpellier ,","place":["France"]},{"name":"Centre Hospitalier Universitaire Saint Eloi, Institute of Regenerative Medicine and Biotherapies , 34295 Montpellier ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u00eflys","family":"Cren","sequence":"additional","affiliation":[{"name":"University of Montpellier , 34095 Montpellier ,","place":["France"]},{"name":"Centre Hospitalier Universitaire Saint Eloi, Institute of Regenerative Medicine and Biotherapies , 34295 Montpellier ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Jorgensen","sequence":"additional","affiliation":[{"name":"INSERM U1183, Institute of Regenerative Medicine and Biotherapies , 34295 Montpellier ,","place":["France"]},{"name":"University of Montpellier , 34095 Montpellier ,","place":["France"]},{"name":"Centre Hospitalier Universitaire Saint Eloi, Institute of Regenerative Medicine and Biotherapies , 34295 Montpellier ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Louis-Plence","sequence":"additional","affiliation":[{"name":"INSERM U1183, Institute of Regenerative Medicine and Biotherapies , 34295 Montpellier ,","place":["France"]},{"name":"University of Montpellier , 34095 Montpellier ,","place":["France"]},{"name":"Centre Hospitalier Universitaire Saint Eloi, Institute of Regenerative Medicine and Biotherapies , 34295 Montpellier ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,1,1]]},"reference":[{"key":"2025030702112065000_r1","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.smim.2011.06.003","article-title":"Regulatory T cell lineage commitment in the thymus","volume":"23","author":"Klein","year":"2011","journal-title":"Semin. 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Stud."},{"key":"2025030702112065000_r30","doi-asserted-by":"crossref","first-page":"3806","DOI":"10.4049\/jimmunol.177.6.3806","article-title":"Immature dendritic cells suppress collagen-induced arthritis by in vivo expansion of CD49b+ regulatory T cells","volume":"177","author":"Charbonnier","year":"2006","journal-title":"J. Immunol."},{"key":"2025030702112065000_r31","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.1002\/art.20513","article-title":"Antigen-specific immunomodulation of collagen-induced arthritis with tumor necrosis factor-stimulated dendritic cells","volume":"50","author":"van Duivenvoorde","year":"2004","journal-title":"Arthritis Rheum."},{"key":"2025030702112065000_r32","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.jaut.2009.10.003","article-title":"Adoptive transfer of IL-10-secreting CD4+CD49b+ regulatory T cells suppresses ongoing arthritis","volume":"34","author":"Charbonnier","year":"2010","journal-title":"J. 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Ther."},{"key":"2025030702112065000_r41","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1084\/jem.20090847","article-title":"PD-L1 regulates the development, maintenance, and function of induced regulatory T cells","volume":"206","author":"Francisco","year":"2009","journal-title":"J. Exp. Med."},{"key":"2025030702112065000_r42","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/eji.200324799","article-title":"Neuropilin-1: a surface marker of regulatory T cells","volume":"34","author":"Bruder","year":"2004","journal-title":"Eur. J. Immunol."},{"key":"2025030702112065000_r43","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1084\/jem.20120822","article-title":"Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo","volume":"209","author":"Yadav","year":"2012","journal-title":"J. Exp. Med."},{"key":"2025030702112065000_r44","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1084\/jem.20120914","article-title":"Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells","volume":"209","author":"Weiss","year":"2012","journal-title":"J. Exp. Med."},{"key":"2025030702112065000_r45","doi-asserted-by":"crossref","first-page":"3433","DOI":"10.4049\/jimmunol.0904028","article-title":"Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells","volume":"184","author":"Thornton","year":"2010","journal-title":"J. Immunol."},{"key":"2025030702112065000_r46","doi-asserted-by":"crossref","first-page":"7767","DOI":"10.1038\/srep07767","article-title":"Concomitant analysis of Helios and Neuropilin-1 as a marker to detect thymic derived regulatory T cells in naive mice","volume":"5","author":"Singh","year":"2015","journal-title":"Sci. Rep."},{"key":"2025030702112065000_r47","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/nature07674","article-title":"Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses","volume":"458","author":"Zheng","year":"2009","journal-title":"Nature"},{"key":"2025030702112065000_r48","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/ni.1731","article-title":"The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation","volume":"10","author":"Koch","year":"2009","journal-title":"Nat. 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Invest."},{"key":"2025030702112065000_r52","doi-asserted-by":"crossref","first-page":"797","DOI":"10.4049\/jimmunol.0901233","article-title":"Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells","volume":"183","author":"Pot","year":"2009","journal-title":"J. Immunol."},{"key":"2025030702112065000_r53","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1002\/eji.201041120","article-title":"Killing of myeloid APCs via HLA class I, CD2 and CD226 defines a novel mechanism of suppression by human Tr1 cells","volume":"41","author":"Magnani","year":"2011","journal-title":"Eur. J. Immunol."},{"key":"2025030702112065000_r54","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.4049\/jimmunol.180.5.2830","article-title":"Mitigation of experimental allergic encephalomyelitis by TGF-beta induced Foxp3+ regulatory T lymphocytes through the induction of anergy and infectious tolerance","volume":"180","author":"Selvaraj","year":"2008","journal-title":"J. Immunol."},{"key":"2025030702112065000_r55","doi-asserted-by":"crossref","first-page":"4730","DOI":"10.4049\/jimmunol.176.8.4730","article-title":"Adaptive islet-specific regulatory CD4 T cells control autoimmune diabetes and mediate the disappearance of pathogenic Th1 cells in vivo","volume":"176","author":"Weber","year":"2006","journal-title":"J. Immunol."},{"key":"2025030702112065000_r56","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/jmcb\/mjs063","article-title":"TNF-\u03b1 impairs differentiation and function of TGF-\u03b2-induced Treg cells in autoimmune diseases through Akt and Smad3 signaling pathway","volume":"5","author":"Zhang","year":"2013","journal-title":"J. Mol. Cell Biol."},{"key":"2025030702112065000_r57","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.intimp.2011.03.001","article-title":"Isolation of functional autologous collagen-II specific IL-10 producing Tr1 cell clones from rheumatoid arthritis blood","volume":"11","author":"Brun","year":"2011","journal-title":"Int. Immunopharmacol."},{"key":"2025030702112065000_r58","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1371\/journal.pbio.0050038","article-title":"Epigenetic control of the foxp3 locus in regulatory T cells","volume":"5","author":"Floess","year":"2007","journal-title":"PLoS Biol."},{"key":"2025030702112065000_r59","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1002\/eji.200838105","article-title":"DNA methylation controls Foxp3 gene expression","volume":"38","author":"Polansky","year":"2008","journal-title":"Eur. J. Immunol."},{"key":"2025030702112065000_r60","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1084\/jem.20061531","article-title":"Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta","volume":"204","author":"Nadkarni","year":"2007","journal-title":"J. Exp. 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Immunol."},{"key":"2025030702112065000_r63","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.immuni.2009.12.004","article-title":"Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell functions","volume":"32","author":"Hegazy","year":"2010","journal-title":"Immunity"},{"key":"2025030702112065000_r64","doi-asserted-by":"crossref","first-page":"548","DOI":"10.3324\/haematol.2014.113803","article-title":"HLA-G expression levels influence the tolerogenic activity of human DC-10","volume":"100","author":"Amodio","year":"2015","journal-title":"Haematologica"},{"key":"2025030702112065000_r65","doi-asserted-by":"crossref","first-page":"5444","DOI":"10.4049\/jimmunol.174.9.5444","article-title":"A role for CD103 in the retention of CD4+CD25+ Treg and control of Leishmania major infection","volume":"174","author":"Suffia","year":"2005","journal-title":"J. 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