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In this study, we report the effect of inhibiting the p110\u03b4 subunit of PI3K\u03b4 on CD8+ T cell responses to infection with the intracellular bacteria Listeria monocytogenes. A strong dependency on PI3K\u03b4 for IFN-\u03b3 production by CD8+ T cells in vitro was not recapitulated after Listeria infection in vivo. Inactivation of PI3K\u03b4 resulted in enhanced bacterial elimination by the innate immune system. However, the magnitudes of the primary and secondary CD8+ T cell responses were reduced. Moreover, PI3K\u03b4 activity was required for CD8+ T cells to provide help to other responding CD8+ cells. These findings identify PI3K\u03b4 as a key regulator of CD8+ T cell responses that integrates extrinsic cues, including those from other responding cells, to determine the collective behavior of CD8+ T cell populations responding to infection.<\/jats:p>","DOI":"10.4049\/jimmunol.1501227","type":"journal-article","created":{"date-parts":[[2015,8,27]],"date-time":"2015-08-27T01:59:27Z","timestamp":1440640767000},"page":"3206-3217","source":"Crossref","is-referenced-by-count":35,"title":["PI3K\u03b4 Regulates the Magnitude of CD8+ T Cell Responses after Challenge with <i>Listeria monocytogenes<\/i>"],"prefix":"10.1093","volume":"195","author":[{"given":"Verity Q","family":"Pearce","sequence":"first","affiliation":[{"name":"Laboratory of Lymphocyte Signalling and Development, Babraham Institute , Cambridge CB22 3AT ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hicham","family":"Bouabe","sequence":"additional","affiliation":[{"name":"Laboratory of Lymphocyte Signalling and Development, Babraham Institute , Cambridge CB22 3AT ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy R","family":"MacQueen","sequence":"additional","affiliation":[{"name":"Laboratory of Lymphocyte Signalling and Development, Babraham Institute , Cambridge CB22 3AT ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Carbonaro","sequence":"additional","affiliation":[{"name":"Laboratory of Lymphocyte Signalling and Development, Babraham Institute , Cambridge CB22 3AT ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9432-4051","authenticated-orcid":false,"given":"Klaus","family":"Okkenhaug","sequence":"additional","affiliation":[{"name":"Laboratory of Lymphocyte Signalling and Development, Babraham Institute , Cambridge CB22 3AT ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,10,1]]},"reference":[{"key":"2025030704152910100_r1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1146\/annurev.immunol.25.022106.141548","article-title":"Effector and memory CTL differentiation","volume":"25","author":"Williams","year":"2007","journal-title":"Annu. 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