{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:34:43Z","timestamp":1790242483119,"version":"4.1.0"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Although it is recognized that lipids and membrane organization in T cells affect signaling and T cell activation, to what extent dietary lipids alter T cell responsiveness in the absence of obesity and inflammation is not known. In this study, we fed low-density lipoprotein receptor knockout mice a Western high-fat diet for 1 or 9 wk and examined T cell responses in vivo along with T cell lipid composition, membrane order, and activation ex vivo. Our data showed that high levels of circulating lipids for a prolonged period elevated CD4+ and CD8+ T cell proliferation and resulted in an increased proportion of CD4+ central-memory T cells within the draining lymph nodes following induction of contact hypersensitivity. In addition, the 9-wk Western high-fat diet elevated the total phospholipid content and monounsaturated fatty acid level, but decreased saturated phosphatidylcholine and sphingomyelin within the T cells. The altered lipid composition in the circulation, and of T cells, was also reflected by enhanced membrane order at the activation site of ex vivo activated T cells that corresponded to increased IL-2 mRNA levels. In conclusion, dietary lipids can modulate T cell lipid composition and responses in lipoprotein receptor knockout mice even in the absence of excess weight gain and a proinflammatory environment.<\/jats:p>","DOI":"10.4049\/jimmunol.1501261","type":"journal-article","created":{"date-parts":[[2016,4,21]],"date-time":"2016-04-21T05:41:12Z","timestamp":1461217272000},"page":"3993-4002","source":"Crossref","is-referenced-by-count":26,"title":["Prolonged Intake of Dietary Lipids Alters Membrane Structure and T Cell Responses in LDLr\u2212\/\u2212 Mice"],"prefix":"10.1093","volume":"196","author":[{"given":"Abigail H","family":"Pollock","sequence":"first","affiliation":[{"name":"European Molecular Biology Laboratory Australia Node in Single Molecule Science, School of Medical Sciences, University of New South Wales , Sydney, New South Wales 2052 ,","place":["Australia"]},{"name":"Australian Research Council Centre of Excellence in Advanced Molecular Imaging, University of New South Wales , Sydney, New South Wales 2052 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8226-8064","authenticated-orcid":false,"given":"Nicodemus","family":"Tedla","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, University of New South Wales , Sydney, New South Wales 2052 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7541-8901","authenticated-orcid":false,"given":"Sarah E","family":"Hancock","sequence":"additional","affiliation":[{"name":"Illawarra Health and Medical Research Institute, University of Wollongong , Wollongong, New South Wales 2522 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhea","family":"Cornely","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory Australia Node in Single Molecule Science, School of Medical Sciences, University of 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Advanced Molecular Imaging, University of New South Wales , Sydney, New South Wales 2052 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0848-5930","authenticated-orcid":false,"given":"Maaike","family":"Kockx","sequence":"additional","affiliation":[{"name":"Australian and New Zealand Army Corps Research Institute, Concord Repatriation General Hospital , Concord, New South Wales 2139 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7494-5248","authenticated-orcid":false,"given":"Robert G","family":"Parton","sequence":"additional","affiliation":[{"name":"Institute of Molecular Bioscience and Centre for Microscopy and Microanalysis, University of Queensland, Australia , St. Lucia, Brisbane, Queensland 4072 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