{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:54:45Z","timestamp":1790430885487,"version":"4.1.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The mucosal immune system is relevant for homeostasis, immunity, and also pathological conditions in the gastrointestinal tract. Inducible NO synthase (iNOS)\u2013dependent production of NO is one of the factors linked to both antimicrobial immunity and pathological conditions. Upregulation of iNOS has been observed in human Helicobacter pylori infection, but the cellular sources of iNOS are ill defined. Key differences in regulation of iNOS expression impair the translation from mouse models to human medicine. To characterize mucosal iNOS-producing leukocytes, biopsy specimens from H. pylori\u2013infected patients, controls, and participants of a vaccination trial were analyzed by immunohistochemistry, along with flow cytometric analyses of lymphocytes for iNOS expression and activity. We newly identified mucosal IgA-producing plasma cells (PCs) as one major iNOS+ cell population in H. pylori\u2013infected patients and confirmed intracellular NO production. Because we did not detect iNOS+ PCs in three distinct infectious diseases, this is not a general feature of mucosal PCs under conditions of infection. Furthermore, numbers of mucosal iNOS+ PCs were elevated in individuals who had cleared experimental H. pylori infection compared with those who had not. Thus, IgA+ PCs expressing iNOS are described for the first time, to our knowledge, in humans. iNOS+ PCs are induced in the course of human H. pylori infection, and their abundance seems to correlate with the clinical course of the infection.<\/jats:p>","DOI":"10.4049\/jimmunol.1501330","type":"journal-article","created":{"date-parts":[[2016,7,25]],"date-time":"2016-07-25T22:43:28Z","timestamp":1469486608000},"page":"1801-1808","source":"Crossref","is-referenced-by-count":19,"title":["Mucosal Inducible NO Synthase\u2013Producing IgA+ Plasma Cells in\n                    <i>Helicobacter pylori<\/i>\n                    \u2013Infected Patients"],"prefix":"10.1093","volume":"197","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7870-7722","authenticated-orcid":false,"given":"Laura","family":"Neumann","sequence":"first","affiliation":[{"name":"Medical Clinic I, Gastroenterology, Infectious Diseases and Rheumatology, Charit\u00e9-University Medicine Berlin , 12203 Berlin,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3340-5122","authenticated-orcid":false,"given":"Mattea","family":"Mueller","sequence":"additional","affiliation":[{"name":"Medical Clinic I, Gastroenterology, Infectious Diseases and Rheumatology, Charit\u00e9-University Medicine Berlin , 12203 Berlin,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Moos","sequence":"additional","affiliation":[{"name":"Medical Clinic I, Gastroenterology, Infectious Diseases and Rheumatology, Charit\u00e9-University Medicine Berlin , 12203 Berlin,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Heller","sequence":"additional","affiliation":[{"name":"Practice for Gastroenterology , 12163 Berlin,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Max Planck Institute for Infection Biology , 10117 Berlin,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8695-8081","authenticated-orcid":false,"given":"Christoph","family":"Loddenkemper","sequence":"additional","affiliation":[{"name":"PathoTres Practice for Pathology , 12247 Berlin,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Bojarski","sequence":"additional","affiliation":[{"name":"Medical Clinic I, Gastroenterology, Infectious Diseases and Rheumatology, Charit\u00e9-University Medicine Berlin , 12203 Berlin,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Fehlings","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Max Planck Institute for Infection Biology , 10117 Berlin,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Doerner","sequence":"additional","affiliation":[{"name":"Department of Medicine, Rheumatology and Clinical Immunology, Charit\u00e9-University Medicine Berlin , 10117 Berlin,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Allers","sequence":"additional","affiliation":[{"name":"Medical Clinic I, Gastroenterology, Infectious Diseases and Rheumatology, Charit\u00e9-University Medicine Berlin , 12203 Berlin,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toni","family":"Aebischer","sequence":"additional","affiliation":[{"name":"Robert Koch Institute , 13302 Berlin,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Ignatius","sequence":"additional","affiliation":[{"name":"Institute for Microbiology and Hygiene, Charit\u00e9-University Medicine Berlin , 12203 Berlin,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Schneider","sequence":"additional","affiliation":[{"name":"Medical Clinic I, Gastroenterology, Infectious Diseases and Rheumatology, Charit\u00e9-University Medicine Berlin , 12203 Berlin,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,9,1]]},"reference":[{"key":"2025030617480142000_r1","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1053\/j.gastro.2007.05.008","article-title":"Immunology of Helicobacter pylori: insights into the failure of the immune response and perspectives on vaccine studies","volume":"133","author":"Wilson","year":"2007","journal-title":"Gastroenterology"},{"key":"2025030617480142000_r2","first-page":"3238","article-title":"Inducible nitric oxide synthase, nitrotyrosine, and apoptosis in Helicobacter pylori gastritis: effect of antibiotics and antioxidants","volume":"56","author":"Mannick","year":"1996","journal-title":"Cancer Res."},{"key":"2025030617480142000_r3","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/S0016-5085(99)70496-8","article-title":"Increased expression and cellular localization of inducible nitric oxide synthase and cyclooxygenase 2 in Helicobacter pylori gastritis","volume":"116","author":"Fu","year":"1999","journal-title":"Gastroenterology"},{"key":"2025030617480142000_r4","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1093\/eurheartj\/ehr304","article-title":"Nitric oxide synthases: regulation and function","volume":"33","author":"F\u00f6rstermann","year":"2012","journal-title":"Eur. Heart J."},{"key":"2025030617480142000_r5","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1023\/A:1020265417394","article-title":"Discovery of some of the biological effects of nitric oxide and its role in cell signaling","volume":"19","author":"Murad","year":"1999","journal-title":"Biosci. Rep."},{"key":"2025030617480142000_r6","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1161\/01.HYP.16.5.477","article-title":"Nitric oxide. A novel signal transduction mechanism for transcellular communication","volume":"16","author":"Ignarro","year":"1990","journal-title":"Hypertension"},{"key":"2025030617480142000_r7","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/1477-7819-11-118","article-title":"Nitric oxide and cancer: a review","volume":"11","author":"Choudhari","year":"2013","journal-title":"World J. Surg. Oncol."},{"key":"2025030617480142000_r8","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.3748\/wjg.v10.i13.1862","article-title":"Expression of COX-2, iNOS, p53 and Ki-67 in gastric mucosa-associated lymphoid tissue lymphoma","volume":"10","author":"Li","year":"2004","journal-title":"World J. Gastroenterol."},{"key":"2025030617480142000_r9","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.niox.2010.04.007","article-title":"Regulation of the expression of inducible nitric oxide synthase","volume":"23","author":"Pautz","year":"2010","journal-title":"Nitric Oxide"},{"key":"2025030617480142000_r10","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/ni.2806","article-title":"Inducible nitric oxide synthase is a major intermediate in signaling pathways for the survival of plasma cells","volume":"15","author":"Saini","year":"2014","journal-title":"Nat. Immunol."},{"key":"2025030617480142000_r11","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/nature10698","article-title":"Acquisition of a multifunctional IgA+ plasma cell phenotype in the gut","volume":"481","author":"Fritz","year":"2011","journal-title":"Nature"},{"key":"2025030617480142000_r12","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1136\/gut.2007.145839","article-title":"Correlation of T cell response and bacterial clearance in human volunteers challenged with Helicobacter pylori revealed by randomised controlled vaccination with Ty21a-based Salmonella vaccines","volume":"57","author":"Aebischer","year":"2008","journal-title":"Gut"},{"key":"2025030617480142000_r13","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1136\/gut.2003.037499","article-title":"Challenge model for Helicobacter pylori infection in human volunteers","volume":"53","author":"Graham","year":"2004","journal-title":"Gut"},{"key":"2025030617480142000_r14","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/path.1485","article-title":"Differential Emu enhancer activity and expression of BOB.1\/OBF.1, Oct2, PU.1, and immunoglobulin in reactive B-cell populations, B-cell non-Hodgkin lymphomas, and Hodgkin lymphomas","volume":"202","author":"Loddenkemper","year":"2004","journal-title":"J. Pathol."},{"key":"2025030617480142000_r15","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1182\/blood.V95.6.2084","article-title":"A monoclonal antibody (MUM1p) detects expression of the MUM1\/IRF4 protein in a subset of germinal center B cells, plasma cells, and activated T cells","volume":"95","author":"Falini","year":"2000","journal-title":"Blood"},{"key":"2025030617480142000_r16","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0022-1759(03)00255-2","article-title":"Optimization of methods to assess human mucosal T-cell responses to HIV infection","volume":"279","author":"Shacklett","year":"2003","journal-title":"J. Immunol. Methods"},{"key":"2025030617480142000_r17","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/BF02621085","article-title":"Human B lymphocytes immortalization by Epstein-Barr virus in the presence of cyclosporin A","volume":"22","author":"Pelloquin","year":"1986","journal-title":"In Vitro Cell. Dev. Biol."},{"key":"2025030617480142000_r18","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1182\/blood-2008-04-153544","article-title":"Blood-borne human plasma cells in steady state are derived from mucosal immune responses","volume":"113","author":"Mei","year":"2009","journal-title":"Blood"},{"key":"2025030617480142000_r19","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1016\/j.freeradbiomed.2012.09.008","article-title":"A multilevel analytical approach for detection and visualization of intracellular NO production and nitrosation events using diaminofluoresceins","volume":"53","author":"Cortese-Krott","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"2025030617480142000_r20","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/(SICI)1522-7243(199911\/12)14:6<283::AID-BIO572>3.0.CO;2-G","article-title":"Practical methods for detection of nitric oxide","volume":"14","author":"Nagano","year":"1999","journal-title":"Luminescence"},{"key":"2025030617480142000_r21","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1101\/gad.6.9.1589","article-title":"Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis","volume":"6","author":"Adams","year":"1992","journal-title":"Genes Dev."},{"key":"2025030617480142000_r22","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1574-695X.2008.00449.x","article-title":"Comparison of mucosal B- and T-cell responses in Helicobacter pylori-infected subjects in a developing and a developed country","volume":"54","author":"Bhuiyan","year":"2008","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"2025030617480142000_r23","doi-asserted-by":"crossref","first-page":"10427","DOI":"10.1128\/JVI.76.20.10427-10436.2002","article-title":"Epstein-Barr virus-induced changes in B-lymphocyte gene expression","volume":"76","author":"Carter","year":"2002","journal-title":"J. Virol."},{"key":"2025030617480142000_r24","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0022-1759(01)00565-8","article-title":"Cell surface phenotyping and cytokine production of Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines (LCLs)","volume":"264","author":"Wroblewski","year":"2002","journal-title":"J. Immunol. Methods"},{"key":"2025030617480142000_r25","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1365-2184.2005.00328.x","article-title":"CD19 signalling improves the Epstein-Barr virus-induced immortalization of human B cell","volume":"38","author":"Hur","year":"2005","journal-title":"Cell Prolif."},{"key":"2025030617480142000_r26","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/0092-8674(94)90005-1","article-title":"Nitric oxide produced by human B lymphocytes inhibits apoptosis and Epstein-Barr virus reactivation","volume":"79","author":"Mannick","year":"1994","journal-title":"Cell"},{"key":"2025030617480142000_r27","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.4049\/jimmunol.136.5.1688","article-title":"In vitro production of interleukin 1 by normal and malignant human B lymphocytes","volume":"136","author":"Pistoia","year":"1986","journal-title":"J. Immunol."},{"key":"2025030617480142000_r28","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1089\/vim.1997.10.183","article-title":"Common and idiosyncratic patterns of cytokine gene expression by Epstein-Barr virus transformed human B cell lines","volume":"10","author":"Rochford","year":"1997","journal-title":"Viral Immunol."},{"key":"2025030617480142000_r29","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1002\/eji.1830200503","article-title":"Production and regulation of interleukin 6 in human B lymphoid cells","volume":"20","author":"Hutchins","year":"1990","journal-title":"Eur. J. Immunol."},{"key":"2025030617480142000_r30","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1084\/jem.168.5.1539","article-title":"Production of tumor necrosis factor\/cachectin by human B cell lines and tonsillar B cells","volume":"168","author":"Sung","year":"1988","journal-title":"J. Exp. Med."},{"key":"2025030617480142000_r31","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1084\/jem.177.2.295","article-title":"Epstein-Barr virus transformation induces B lymphocytes to produce human interleukin 10","volume":"177","author":"Burdin","year":"1993","journal-title":"J. Exp. Med."},{"key":"2025030617480142000_r32","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1111\/j.1349-7006.2011.01924.x","article-title":"Cytokine signatures of transformed B cells with distinct Epstein-Barr virus latencies as a potential diagnostic tool for B cell lymphoma","volume":"102","author":"Miyauchi","year":"2011","journal-title":"Cancer Sci."},{"key":"2025030617480142000_r33","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1128\/IAI.66.6.2705-2712.1998","article-title":"Antibody-secreting cells in the stomachs of symptomatic and asymptomatic Helicobacter pylori-infected subjects","volume":"66","author":"Mattsson","year":"1998","journal-title":"Infect. Immun."},{"key":"2025030617480142000_r34","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.niox.2008.04.017","article-title":"Stimulation of iNOS expression and apoptosis resistance in B-cell chronic lymphocytic leukemia (B-CLL) cells through engagement of Toll-like receptor 7 (TLR-7) and NF-kappaB activation","volume":"19","author":"Hammadi","year":"2008","journal-title":"Nitric Oxide"},{"key":"2025030617480142000_r35","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1006\/bbrc.1998.9062","article-title":"Analysis of the cytokine-stimulated human inducible nitric oxide synthase (iNOS) gene: characterization of differences between human and mouse iNOS promoters","volume":"248","author":"Chu","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2025030617480142000_r36","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1073\/pnas.93.6.2442","article-title":"Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53","volume":"93","author":"Forrester","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"2025030617480142000_r37","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.4049\/jimmunol.171.4.1684","article-title":"Plasma cell survival is mediated by synergistic effects of cytokines and adhesion-dependent signals","volume":"171","author":"Cassese","year":"2003","journal-title":"J. Immunol."},{"key":"2025030617480142000_r38","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1136\/gut.32.12.1473","article-title":"Mucosal tumour necrosis factor alpha and interleukin-6 in patients with Helicobacter pylori associated gastritis","volume":"32","author":"Crabtree","year":"1991","journal-title":"Gut"},{"key":"2025030617480142000_r39","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.bbrc.2011.06.035","article-title":"iNOS potentiates mouse Ig isotype switching through AID expression","volume":"410","author":"Lee","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2025030617480142000_r40","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/nature06033","article-title":"Regulation of IgA production by naturally occurring TNF\/iNOS-producing dendritic cells","volume":"448","author":"Tezuka","year":"2007","journal-title":"Nature"},{"key":"2025030617480142000_r41","doi-asserted-by":"crossref","first-page":"8144","DOI":"10.4049\/jimmunol.174.12.8144","article-title":"IgA antibodies impair resistance against Helicobacter pylori infection: studies on immune evasion in IL-10-deficient mice","volume":"174","author":"Akhiani","year":"2005","journal-title":"J. Immunol."},{"key":"2025030617480142000_r42","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1046\/j.1365-2249.1996.d01-745.x","article-title":"Helicobacter pylori infections in IgA deficiency: lack of role for the secretory immune system","volume":"105","author":"Bogstedt","year":"1996","journal-title":"Clin. Exp. Immunol."},{"key":"2025030617480142000_r43","doi-asserted-by":"crossref","first-page":"S250","DOI":"10.1111\/j.1440-1746.2008.05412.x","article-title":"Expression of inducible nitric oxide synthase and nitric oxide-modified proteins in Helicobacter pylori-associated atrophic gastric mucosa","volume":"23","author":"Naito","year":"2008","journal-title":"J. Gastroenterol. Hepatol."},{"key":"2025030617480142000_r44","doi-asserted-by":"crossref","first-page":"15217","DOI":"10.1073\/pnas.1009017107","article-title":"Mutagenic potency of Helicobacter pylori in the gastric mucosa of mice is determined by sex and duration of infection","volume":"107","author":"Sheh","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"2025030617480142000_r45","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/S0002-9440(10)63876-X","article-title":"Inducible nitric oxide synthase expression in human colorectal cancer: correlation with tumor angiogenesis","volume":"162","author":"Cianchi","year":"2003","journal-title":"Am. J. Pathol."},{"key":"2025030617480142000_r46","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/jso.20372","article-title":"Expression of inducible nitric oxide synthase and cyclooxygenase-2 in angiogenesis and clinical outcome of human gastric cancer","volume":"94","author":"Chen","year":"2006","journal-title":"J. Surg. Oncol."},{"key":"2025030617480142000_r47","doi-asserted-by":"crossref","first-page":"591","DOI":"10.3748\/wjg.v8.i4.591","article-title":"Relationship between the expression of iNOS,VEGF,tumor angiogenesis and gastric cancer","volume":"8","author":"Song","year":"2002","journal-title":"World J. Gastroenterol."},{"key":"2025030617480142000_r48","doi-asserted-by":"crossref","first-page":"4917","DOI":"10.3748\/wjg.v18.i35.4917","article-title":"Inducible nitric oxide synthetase genotype and Helicobacter pylori infection affect gastric cancer risk","volume":"18","author":"Rafiei","year":"2012","journal-title":"World J. Gastroenterol."},{"key":"2025030617480142000_r49","doi-asserted-by":"crossref","first-page":"6361","DOI":"10.3748\/wjg.v12.i39.6361","article-title":"Inducible nitric oxide synthase polymorphism is associated with the increased risk of differentiated gastric cancer in a Japanese population","volume":"12","author":"Goto","year":"2006","journal-title":"World J. Gastroenterol."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/197\/5\/1801\/61580107\/1501330.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/197\/5\/1801\/61580107\/1501330.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T14:02:38Z","timestamp":1741269758000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/197\/5\/1801\/7974568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,1]]},"references-count":49,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,9,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1501330","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2016,9]]},"published":{"date-parts":[[2016,9,1]]}}}