{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:38:14Z","timestamp":1788932294253,"version":"build-2803163510"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>T cells from patients with systemic lupus erythematosus (SLE) display a number of abnormalities, including increased early signaling events following engagement of the TCR. Signaling lymphocytic activation molecule family cell surface receptors and the X-chromosome\u2013defined signaling lymphocytic activation molecule-associated protein (SAP) adaptor are important in the development of several immunocyte lineages and modulating the immune response. We present evidence that SAP protein levels are decreased in T cells and in their main subsets isolated from 32 women and three men with SLE, independent of disease activity. In SLE T cells, SAP protein is also subject to increased degradation by caspase-3. Forced expression of SAP in SLE T cells normalized IL-2 production, calcium (Ca2+) responses, and tyrosine phosphorylation of a number of proteins. Exposure of normal T cells to SLE serum IgG, known to contain anti-CD3\/TCR Abs, resulted in SAP downregulation. We conclude that SLE T cells display reduced levels of the adaptor protein SAP, probably as a result of continuous T cell activation and degradation by caspase-3. Restoration of SAP levels in SLE T cells corrects the overexcitable lupus T cell phenotype.<\/jats:p>","DOI":"10.4049\/jimmunol.1501523","type":"journal-article","created":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T03:05:38Z","timestamp":1463022338000},"page":"4915-4924","source":"Crossref","is-referenced-by-count":16,"title":["Decreased SAP Expression in T Cells from Patients with Systemic Lupus Erythematosus Contributes to Early Signaling Abnormalities and Reduced IL-2 Production"],"prefix":"10.1093","volume":"196","author":[{"given":"Maria P","family":"Karampetsou","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA 02215"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Comte","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA 02215"},{"name":"Service d'Immunologie et Allergie, Centre Hospitalier Universitaire Vaudois , CH 1011 Lausanne ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katalin","family":"Kis-Toth","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA 02215"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cox","family":"Terhorst","sequence":"additional","affiliation":[{"name":"Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA 02215"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasileios C","family":"Kyttaris","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA 02215"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9589-2360","authenticated-orcid":false,"given":"George C","family":"Tsokos","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA 02215"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,6,15]]},"reference":[{"key":"2025030702181958500_r1","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1056\/NEJMra1100359","article-title":"Systemic lupus erythematosus","volume":"365","author":"Tsokos","year":"2011","journal-title":"N. 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