{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:31:44Z","timestamp":1792024304412,"version":"4.4.0"},"reference-count":84,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Type I IFNs play critical roles in orchestrating the antiviral defense by inducing direct antiviral activities and shaping the adaptive immune response. Viruses have evolved numerous strategies to specifically interfere with IFN production or its downstream mediators, thereby allowing successful infection of the host to occur. The prototypic human gammaherpesvirus EBV, which is associated with infectious mononucleosis and malignant tumors, harbors many immune-evasion proteins that manipulate the adaptive and innate immune systems. In addition to proteins, the virus encodes &amp;gt;40 mature microRNAs for which the functions remain largely unknown. In this article, we identify EBV-encoded miR-BART16 as a novel viral immune-evasion factor that interferes with the type I IFN signaling pathway. miR-BART16 directly targets CREB-binding protein, a key transcriptional coactivator in IFN signaling, thereby inducing CREB-binding protein downregulation in EBV-transformed B cells and gastric carcinoma cells. miR-BART16 abrogates the production of IFN-stimulated genes in response to IFN-\u03b1 stimulation and it inhibits the antiproliferative effect of IFN-\u03b1 on latently infected BL cells. By obstructing the type I IFN\u2013induced antiviral response, miR-BART16 provides a means to facilitate the establishment of latent EBV infection and enhance viral replication.<\/jats:p>","DOI":"10.4049\/jimmunol.1501605","type":"journal-article","created":{"date-parts":[[2017,4,18]],"date-time":"2017-04-18T00:20:19Z","timestamp":1492474819000},"page":"4062-4073","source":"Crossref","is-referenced-by-count":97,"title":["EBV MicroRNA BART16 Suppresses Type I IFN Signaling"],"prefix":"10.1093","volume":"198","author":[{"given":"Marjolein J G","family":"Hooykaas","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology, University Medical Center Utrecht , 3584 CX Utrecht,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiel","family":"van Gent","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, University Medical Center Utrecht , 3584 CX Utrecht,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasper A","family":"Soppe","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, University Medical Center Utrecht , 3584 CX Utrecht,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Kruse","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, University Medical Center Utrecht , 3584 CX Utrecht,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid G J","family":"Boer","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, University Medical Center Utrecht , 3584 CX Utrecht,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dik","family":"van Leenen","sequence":"additional","affiliation":[{"name":"Department of Molecular Cancer Research, University Medical Center Utrecht , 3584 CX Utrecht,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0867-0821","authenticated-orcid":false,"given":"Marian J A","family":"Groot Koerkamp","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology , 3584 EA Utrecht,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank C P","family":"Holstege","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology , 3584 EA Utrecht,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5188-2267","authenticated-orcid":false,"given":"Maaike E","family":"Ressing","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, University Medical Center Utrecht , 3584 CX Utrecht,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel J H J","family":"Wiertz","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, University Medical Center Utrecht , 3584 CX Utrecht,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert Jan","family":"Lebbink","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, University Medical Center Utrecht , 3584 CX Utrecht,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,5,15]]},"reference":[{"key":"2025030615140774200_r1","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern recognition receptors and inflammation","volume":"140","author":"Takeuchi","year":"2010","journal-title":"Cell"},{"key":"2025030615140774200_r2","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.coviro.2011.10.008","article-title":"Interferon-stimulated genes and their antiviral effector functions","volume":"1","author":"Schoggins","year":"2011","journal-title":"Curr. 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