{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T04:46:10Z","timestamp":1783831570669,"version":"3.55.0"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Although Notch signaling plays important roles in lineage commitment and differentiation of multiple cell types including conventional T cells, nothing is currently known concerning Notch function in innate-like T cells. We have found that the homeostasis of several well-characterized populations of innate-like T cells including invariant NKT cells (iNKT), CD8\u03b1\u03b1TCR\u03b1\u03b2 small intestinal intraepithelial lymphocytes, and innate memory phenotype CD8 T cells is controlled by Notch. Notch selectively regulates hepatic iNKT cell survival via tissue-restricted control of B cell lymphoma 2 and IL-7R\u03b1 expression. More generally, Notch regulation of innate-like T cell homeostasis involves both cell-intrinsic and -extrinsic mechanisms and relies upon context-dependent interactions with Notch ligand-expressing fibroblastic stromal cells. Collectively, using conditional ablation of Notch receptors on peripheral T cells or Notch ligands on putative fibroblastic stromal cells, we show that Notch signaling is indispensable for the homeostasis of three tissue-restricted populations of innate-like T cells: hepatic iNKT, CD8\u03b1\u03b1TCR\u03b1\u03b2 small intestinal intraepithelial lymphocytes, and innate memory phenotype CD8 T cells, thus supporting a generalized role for Notch in innate T cell homeostasis.<\/jats:p>","DOI":"10.4049\/jimmunol.1501675","type":"journal-article","created":{"date-parts":[[2016,6,21]],"date-time":"2016-06-21T03:24:23Z","timestamp":1466479463000},"page":"771-782","source":"Crossref","is-referenced-by-count":4,"title":["Notch Signaling Regulates the Homeostasis of Tissue-Restricted Innate-like T Cells"],"prefix":"10.1093","volume":"197","author":[{"given":"Vijaykumar","family":"Chennupati","sequence":"first","affiliation":[{"name":"Ludwig Centre for Cancer Research, University of Lausanne , 1066 Epalinges,","place":["Switzerland"]},{"name":"Swiss Vaccine Research Institute, Lausanne University Hospital , 1066 Epalinges,","place":["Switzerland"]},{"name":"Division of Immunology and Allergy, Department of Medicine, Lausanne University Hospital , 1066 Epalinges,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7914-7061","authenticated-orcid":false,"given":"Ute","family":"Koch","sequence":"additional","affiliation":[{"name":"Swiss Federal Institute of Technology Lausanne, School of Life Sciences, Swiss Institute for Experimental Cancer Research , 1015 Lausanne,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Coutaz","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, World Health Organization Immunology Research and Training Centre, University of Lausanne , 1066 Epalinges,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Scarpellino","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Lausanne , 1066 Epalinges,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Tacchini-Cottier","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, World Health Organization Immunology Research and Training Centre, University of Lausanne , 1066 Epalinges,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjiv A","family":"Luther","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Lausanne , 1066 Epalinges,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freddy","family":"Radtke","sequence":"additional","affiliation":[{"name":"Swiss Federal Institute of Technology Lausanne, School of Life Sciences, Swiss Institute for Experimental Cancer Research , 1015 Lausanne,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietmar","family":"Zehn","sequence":"additional","affiliation":[{"name":"Swiss Vaccine Research Institute, Lausanne University Hospital , 1066 Epalinges,","place":["Switzerland"]},{"name":"Division of Immunology and Allergy, Department of Medicine, Lausanne University Hospital , 1066 Epalinges,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H Robson","family":"MacDonald","sequence":"additional","affiliation":[{"name":"Ludwig Centre for Cancer Research, University of Lausanne , 1066 Epalinges,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,8,1]]},"reference":[{"key":"2025030617465383100_r1","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nri3445","article-title":"Regulation of innate and adaptive immunity by Notch","volume":"13","author":"Radtke","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"2025030617465383100_r2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/978-1-4614-0899-4_6","article-title":"Notch signaling and development of the hematopoietic system","volume":"727","author":"Sandy","year":"2012","journal-title":"Adv. Exp. Med. Biol."},{"key":"2025030617465383100_r3","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S1074-7613(00)80054-0","article-title":"Deficient T cell fate specification in mice with an induced inactivation of Notch1","volume":"10","author":"Radtke","year":"1999","journal-title":"Immunity"},{"key":"2025030617465383100_r4","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S1074-7613(01)00107-8","article-title":"Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength","volume":"14","author":"Izon","year":"2001","journal-title":"Immunity"},{"key":"2025030617465383100_r5","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S1074-7613(03)00111-0","article-title":"Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development","volume":"18","author":"Saito","year":"2003","journal-title":"Immunity"},{"key":"2025030617465383100_r6","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.4049\/jimmunol.1300643","article-title":"Notch signaling regulates follicular helper T cell differentiation","volume":"191","author":"Auderset","year":"2013","journal-title":"J. Immunol."},{"key":"2025030617465383100_r7","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.immuni.2011.08.013","article-title":"Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine","volume":"35","author":"Lewis","year":"2011","journal-title":"Immunity"},{"key":"2025030617465383100_r8","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1084\/jem.20111594","article-title":"Notch, Id2, and ROR\u03b3t sequentially orchestrate the fetal development of lymphoid tissue inducer cells","volume":"209","author":"Cherrier","year":"2012","journal-title":"J. Exp. Med."},{"key":"2025030617465383100_r9","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1084\/jem.180.4.1345","article-title":"Oligoclonal repertoire of the CD8 alpha alpha and the CD8 alpha beta TCR-alpha\/beta murine intestinal intraepithelial T lymphocytes: evidence for the random emergence of T cells","volume":"180","author":"Regnault","year":"1994","journal-title":"J. Exp. Med."},{"key":"2025030617465383100_r10","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.4049\/jimmunol.176.4.2064","article-title":"Cutting edge: influence of the TCR Vbeta domain on the selection of semi-invariant NKT cells by endogenous ligands","volume":"176","author":"Sch\u00fcmann","year":"2006","journal-title":"J. Immunol."},{"key":"2025030617465383100_r11","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.immuni.2006.08.018","article-title":"Identification of pre- and postselection TCRalphabeta+ intraepithelial lymphocyte precursors in the thymus","volume":"25","author":"Gangadharan","year":"2006","journal-title":"Immunity"},{"key":"2025030617465383100_r12","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1126\/science.1103440","article-title":"Lysosomal glycosphingolipid recognition by NKT cells","volume":"306","author":"Zhou","year":"2004","journal-title":"Science"},{"key":"2025030617465383100_r13","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.immuni.2007.08.020","article-title":"Homotypic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage development","volume":"27","author":"Griewank","year":"2007","journal-title":"Immunity"},{"key":"2025030617465383100_r14","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1084\/jem.20050456","article-title":"Characterization of the early stages of thymic NKT cell development","volume":"202","author":"Benlagha","year":"2005","journal-title":"J. Exp. Med."},{"key":"2025030617465383100_r15","doi-asserted-by":"crossref","first-page":"e113","DOI":"10.1371\/journal.pbio.0030113","article-title":"Intravascular immune surveillance by CXCR6+ NKT cells patrolling liver sinusoids","volume":"3","author":"Geissmann","year":"2005","journal-title":"PLoS Biol."},{"key":"2025030617465383100_r16","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4049\/jimmunol.181.1.81","article-title":"Critical role for the chemokine receptor CXCR6 in homeostasis and activation of CD1d-restricted NKT cells","volume":"181","author":"Germanov","year":"2008","journal-title":"J. Immunol."},{"key":"2025030617465383100_r17","doi-asserted-by":"crossref","first-page":"6335","DOI":"10.4049\/jimmunol.1003965","article-title":"IL-15 regulates homeostasis and terminal maturation of NKT cells","volume":"187","author":"Gordy","year":"2011","journal-title":"J. Immunol."},{"key":"2025030617465383100_r18","doi-asserted-by":"crossref","first-page":"4444","DOI":"10.4049\/jimmunol.1201181","article-title":"Role of hepatocyte-derived IL-7 in maintenance of intrahepatic NKT cells and T cells and development of B cells in fetal liver","volume":"189","author":"Liang","year":"2012","journal-title":"J. Immunol."},{"key":"2025030617465383100_r19","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1038\/ni.2731","article-title":"Steady-state production of IL-4 modulates immunity in mouse strains and is determined by lineage diversity of iNKT cells","volume":"14","author":"Lee","year":"2013","journal-title":"Nat. Immunol."},{"key":"2025030617465383100_r20","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.it.2010.12.004","article-title":"Alternative memory in the CD8 T cell lineage","volume":"32","author":"Lee","year":"2011","journal-title":"Trends Immunol."},{"key":"2025030617465383100_r21","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/ni.1898","article-title":"T cells expressing the transcription factor PLZF regulate the development of memory-like CD8+ T cells","volume":"11","author":"Weinreich","year":"2010","journal-title":"Nat. Immunol."},{"key":"2025030617465383100_r22","doi-asserted-by":"crossref","first-page":"4431","DOI":"10.1182\/blood-2009-11-254698","article-title":"c-Myc controls the development of CD8alphaalpha TCRalphabeta intestinal intraepithelial lymphocytes from thymic precursors by regulating IL-15-dependent survival","volume":"115","author":"Jiang","year":"2010","journal-title":"Blood"},{"key":"2025030617465383100_r23","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.immuni.2014.06.018","article-title":"The transcription factor T-bet is induced by IL-15 and thymic agonist selection and controls CD8\u03b1\u03b1(+) intraepithelial lymphocyte development","volume":"41","author":"Klose","year":"2014","journal-title":"Immunity"},{"key":"2025030617465383100_r24","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.immuni.2014.06.017","article-title":"Transcription factor T-bet regulates intraepithelial lymphocyte functional maturation","volume":"41","author":"Reis","year":"2014","journal-title":"Immunity"},{"key":"2025030617465383100_r25","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.immuni.2013.08.019","article-title":"Transforming growth factor-\u03b2 signaling controls the formation and maintenance of gut-resident memory T cells by regulating migration and retention","volume":"39","author":"Zhang","year":"2013","journal-title":"Immunity"},{"key":"2025030617465383100_r26","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1006\/cimm.2001.1765","article-title":"IL-7 prevents both caspase-dependent and -independent pathways that lead to the spontaneous apoptosis of i-IEL","volume":"208","author":"Yada","year":"2001","journal-title":"Cell. Immunol."},{"key":"2025030617465383100_r27","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/ni.1997","article-title":"Control of the development of CD8\u03b1\u03b1+ intestinal intraepithelial lymphocytes by TGF-\u03b2","volume":"12","author":"Konkel","year":"2011","journal-title":"Nat. Immunol."},{"key":"2025030617465383100_r28","doi-asserted-by":"crossref","first-page":"4641","DOI":"10.4049\/jimmunol.0803394","article-title":"Selective requirement for c-Myc at an early stage of V(alpha)14i NKT cell development","volume":"182","author":"Mycko","year":"2009","journal-title":"J. Immunol."},{"key":"2025030617465383100_r29","doi-asserted-by":"crossref","first-page":"5815","DOI":"10.4049\/jimmunol.170.12.5815","article-title":"Cutting edge: influence of the TCR V beta domain on the avidity of CD1d:alpha-galactosylceramide binding by invariant V alpha 14 NKT cells","volume":"170","author":"Sch\u00fcmann","year":"2003","journal-title":"J. Immunol."},{"key":"2025030617465383100_r30","doi-asserted-by":"crossref","first-page":"5160","DOI":"10.4049\/jimmunol.1001652","article-title":"Intra- and intercompartmental movement of gammadelta T cells: intestinal intraepithelial and peripheral gammadelta T cells represent exclusive nonoverlapping populations with distinct migration characteristics","volume":"185","author":"Chennupati","year":"2010","journal-title":"J. Immunol."},{"key":"2025030617465383100_r31","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1084\/jem.20132528","article-title":"Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses","volume":"211","author":"Fasnacht","year":"2014","journal-title":"J. Exp. Med."},{"key":"2025030617465383100_r32","doi-asserted-by":"crossref","first-page":"7212","DOI":"10.4049\/jimmunol.0902432","article-title":"Dynamic regulation of notch 1 and notch 2 surface expression during T cell development and activation revealed by novel monoclonal antibodies","volume":"183","author":"Fiorini","year":"2009","journal-title":"J. Immunol."},{"key":"2025030617465383100_r33","doi-asserted-by":"crossref","first-page":"e1002560","DOI":"10.1371\/journal.ppat.1002560","article-title":"Redundant Notch1 and Notch2 signaling is necessary for IFN\u03b3 secretion by T helper 1 cells during infection with Leishmania major","volume":"8","author":"Auderset","year":"2012","journal-title":"PLoS Pathog."},{"key":"2025030617465383100_r34","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nri981","article-title":"Hepatic T cells and liver tolerance","volume":"3","author":"Crispe","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"2025030617465383100_r35","doi-asserted-by":"crossref","first-page":"19461","DOI":"10.1073\/pnas.0908249106","article-title":"Transcriptional regulator Id2 controls survival of hepatic NKT cells","volume":"106","author":"Monticelli","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030617465383100_r36","doi-asserted-by":"crossref","first-page":"7407","DOI":"10.1073\/pnas.1221984110","article-title":"Critical role for miR-181a\/b-1 in agonist selection of invariant natural killer T cells","volume":"110","author":"Zi\u0119tara","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030617465383100_r37","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.immuni.2013.02.008","article-title":"Agonist-selected T cell development requires strong T cell receptor signaling and store-operated calcium entry","volume":"38","author":"Oh-Hora","year":"2013","journal-title":"Immunity"},{"key":"2025030617465383100_r38","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1182\/blood-2010-03-277103","article-title":"Thymic and peripheral microenvironments differentially mediate development and maturation of iNKT cells by IL-15 transpresentation","volume":"116","author":"Castillo","year":"2010","journal-title":"Blood"},{"key":"2025030617465383100_r39","doi-asserted-by":"crossref","first-page":"3711","DOI":"10.4049\/jimmunol.177.6.3711","article-title":"Notch1 and IL-7 receptor interplay maintains proliferation of human thymic progenitors while suppressing non-T cell fates","volume":"177","author":"Garc\u00eda-Peydr\u00f3","year":"2006","journal-title":"J. Immunol."},{"key":"2025030617465383100_r40","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1084\/jem.20081922","article-title":"CSL-MAML-dependent Notch1 signaling controls T lineage-specific IL-7Ralpha gene expression in early human thymopoiesis and leukemia","volume":"206","author":"Gonz\u00e1lez-Garc\u00eda","year":"2009","journal-title":"J. Exp. Med."},{"key":"2025030617465383100_r41","first-page":"47","article-title":"Notch1 and IL-7 receptor signalling in early T-cell development and leukaemia","volume":"360","author":"Gonz\u00e1lez-Garc\u00eda","year":"2012","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"2025030617465383100_r42","doi-asserted-by":"crossref","first-page":"14908","DOI":"10.1073\/pnas.1109023108","article-title":"Genome-wide analysis reveals conserved and divergent features of Notch1\/RBPJ binding in human and murine T-lymphoblastic leukemia cells","volume":"108","author":"Wang","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030617465383100_r43","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0092-8674(00)80291-3","article-title":"Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice","volume":"89","author":"Akashi","year":"1997","journal-title":"Cell"},{"key":"2025030617465383100_r44","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/S0092-8674(00)80289-5","article-title":"Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-\/- mice","volume":"89","author":"Maraskovsky","year":"1997","journal-title":"Cell"},{"key":"2025030617465383100_r45","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1038\/mi.2013.122","article-title":"IL-17-producing NKT cells depend exclusively on IL-7 for homeostasis and survival","volume":"7","author":"Webster","year":"2014","journal-title":"Mucosal Immunol."},{"key":"2025030617465383100_r46","doi-asserted-by":"crossref","first-page":"17549","DOI":"10.1073\/pnas.1204327109","article-title":"Interleukin 7 (IL-7) selectively promotes mouse and human IL-17-producing \u03b3\u03b4 cells","volume":"109","author":"Michel","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030617465383100_r47","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.4049\/jimmunol.1301116","article-title":"Notch signaling regulates T cell accumulation and function in the central nervous system during experimental autoimmune encephalomyelitis","volume":"191","author":"Sandy","year":"2013","journal-title":"J. Immunol."},{"key":"2025030617465383100_r48","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.immuni.2013.07.006","article-title":"Notch simultaneously orchestrates multiple helper T cell programs independently of cytokine signals","volume":"39","author":"Bailis","year":"2013","journal-title":"Immunity"},{"key":"2025030617465383100_r49","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1172\/JCI65477","article-title":"Blockade of individual Notch ligands and receptors controls graft-versus-host disease","volume":"123","author":"Tran","year":"2013","journal-title":"J. Clin. Invest."},{"key":"2025030617465383100_r50","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.immuni.2006.04.009","article-title":"The interleukin-4 enhancer CNS-2 is regulated by Notch signals and controls initial expression in NKT cells and memory-type CD4 T cells","volume":"24","author":"Tanaka","year":"2006","journal-title":"Immunity"},{"key":"2025030617465383100_r51","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.immuni.2007.04.018","article-title":"Notch directly regulates Gata3 expression during T helper 2 cell differentiation","volume":"27","author":"Fang","year":"2007","journal-title":"Immunity"},{"key":"2025030617465383100_r52","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.immuni.2012.01.020","article-title":"Notch receptors and Smad3 signaling cooperate in the induction of interleukin-9-producing T cells","volume":"36","author":"Elyaman","year":"2012","journal-title":"Immunity"},{"key":"2025030617465383100_r53","doi-asserted-by":"crossref","first-page":"4685","DOI":"10.1172\/JCI45797","article-title":"Crosstalk between the canonical NF-\u03baB and Notch signaling pathways inhibits Ppar\u03b3 expression and promotes pancreatic cancer progression in mice","volume":"121","author":"Maniati","year":"2011","journal-title":"J. Clin. Invest."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/197\/3\/771\/61579681\/1501675.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/197\/3\/771\/61579681\/1501675.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T18:56:25Z","timestamp":1741287385000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/197\/3\/771\/7974532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,1]]},"references-count":53,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,8,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1501675","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2016,8]]},"published":{"date-parts":[[2016,8,1]]}}}