{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:06:19Z","timestamp":1790960779884,"version":"4.1.0"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Memory stem T cells (TSCMs) constitute a long-lived, self-renewing lymphocyte population essential for the maintenance of functional immunity. Hallmarks of autoimmune disease pathogenesis are abnormal CD4+ and CD8+ T cell activation. We investigated the TSCM subset in 55, 34, 43, and 5 patients with acquired aplastic anemia (AA), autoimmune uveitis, systemic lupus erythematosus, and sickle cell disease, respectively, as well as in 41 age-matched healthy controls. CD8+ TSCM frequency was significantly increased in AA compared with healthy controls. An increased CD8+ TSCM frequency at diagnosis was associated with responsiveness to immunosuppressive therapy, and an elevated CD8+ TSCM population after immunosuppressive therapy correlated with treatment failure or relapse in AA patients. IFN-\u03b3 and IL-2 production was significantly increased in various CD8+ and CD4+ T cell subsets in AA patients, including CD8+ and CD4+ TSCMs. CD8+ TSCM frequency was also increased in patients with autoimmune uveitis or sickle cell disease. A positive correlation between CD4+ and CD8+ TSCM frequencies was found in AA, autoimmune uveitis, and systemic lupus erythematosus. Evaluation of PD-1, CD160, and CD244 expression revealed that TSCMs were less exhausted compared with other types of memory T cells. Our results suggest that the CD8+ TSCM subset is a novel biomarker and a potential therapeutic target for AA.<\/jats:p>","DOI":"10.4049\/jimmunol.1501739","type":"journal-article","created":{"date-parts":[[2016,1,14]],"date-time":"2016-01-14T04:05:26Z","timestamp":1452744326000},"page":"1568-1578","source":"Crossref","is-referenced-by-count":88,"title":["Memory Stem T Cells in Autoimmune Disease: High Frequency of Circulating CD8+ Memory Stem Cells in Acquired Aplastic Anemia"],"prefix":"10.1093","volume":"196","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3423-1523","authenticated-orcid":false,"given":"Kohei","family":"Hosokawa","sequence":"first","affiliation":[{"name":"Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawel","family":"Muranski","sequence":"additional","affiliation":[{"name":"Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingmin","family":"Feng","sequence":"additional","affiliation":[{"name":"Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle M","family":"Townsley","sequence":"additional","affiliation":[{"name":"Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoying","family":"Liu","sequence":"additional","affiliation":[{"name":"Clinical Immunology Section, National Eye Institute, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared","family":"Knickelbein","sequence":"additional","affiliation":[{"name":"Clinical Immunology Section, National Eye Institute, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyvan","family":"Keyvanfar","sequence":"additional","affiliation":[{"name":"Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan","family":"Dumitriu","sequence":"additional","affiliation":[{"name":"Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sawa","family":"Ito","sequence":"additional","affiliation":[{"name":"Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1035-3662","authenticated-orcid":false,"given":"Sachiko","family":"Kajigaya","sequence":"additional","affiliation":[{"name":"Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"VI","given":"James G","family":"Taylor","sequence":"additional","affiliation":[{"name":"Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana J","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B","family":"Nussenblatt","sequence":"additional","affiliation":[{"name":"Clinical Immunology Section, National Eye Institute, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A John","family":"Barrett","sequence":"additional","affiliation":[{"name":"Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6456-9752","authenticated-orcid":false,"given":"John","family":"O\u2019Shea","sequence":"additional","affiliation":[{"name":"Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal S","family":"Young","sequence":"additional","affiliation":[{"name":"Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,2,15]]},"reference":[{"key":"2025030702130533100_r1","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1182\/blood-2006-03-010777","article-title":"Current concepts in the pathophysiology and treatment of aplastic anemia","volume":"108","author":"Young","year":"2006","journal-title":"Blood"},{"key":"2025030702130533100_r2","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1182\/blood-2011-12-274019","article-title":"How I treat acquired aplastic anemia","volume":"120","author":"Scheinberg","year":"2012","journal-title":"Blood"},{"key":"2025030702130533100_r3","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1182\/blood-2002-01-0236","article-title":"Oligoclonal and polyclonal CD4 and CD8 lymphocytes in aplastic anemia and paroxysmal nocturnal hemoglobinuria measured by V beta CDR3 spectratyping and flow cytometry","volume":"100","author":"Risitano","year":"2002","journal-title":"Blood"},{"key":"2025030702130533100_r4","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1182\/blood.V89.10.3691","article-title":"Isolation of a T-cell clone showing HLA-DRB1*0405-restricted cytotoxicity for hematopoietic cells in a patient with aplastic anemia","volume":"89","author":"Nakao","year":"1997","journal-title":"Blood"},{"key":"2025030702130533100_r5","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1182\/blood-2002-01-0035","article-title":"Intracellular interferon-gamma in circulating and marrow T cells detected by flow cytometry and the response to immunosuppressive therapy in patients with aplastic anemia","volume":"100","author":"Sloand","year":"2002","journal-title":"Blood"},{"key":"2025030702130533100_r6","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0140-6736(04)16724-X","article-title":"In-vivo dominant immune responses in aplastic anaemia: molecular tracking of putatively pathogenetic T-cell clones by TCR beta-CDR3 sequencing","volume":"364","author":"Risitano","year":"2004","journal-title":"Lancet"},{"key":"2025030702130533100_r7","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.1182\/blood.V98.13.3513","article-title":"Increased frequency of HLA-DR2 in patients with paroxysmal nocturnal hemoglobinuria and the PNH\/aplastic anemia syndrome","volume":"98","author":"Maciejewski","year":"2001","journal-title":"Blood"},{"key":"2025030702130533100_r8","doi-asserted-by":"crossref","first-page":"6601","DOI":"10.1182\/blood-2011-07-365189","article-title":"Frequent loss of HLA alleles associated with copy number-neutral 6pLOH in acquired aplastic anemia","volume":"118","author":"Katagiri","year":"2011","journal-title":"Blood"},{"key":"2025030702130533100_r9","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1056\/NEJMoa1103975","article-title":"Horse versus rabbit antithymocyte globulin in acquired aplastic anemia","volume":"365","author":"Scheinberg","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"2025030702130533100_r10","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/44385","article-title":"Two subsets of memory T lymphocytes with distinct homing potentials and effector functions","volume":"401","author":"Sallusto","year":"1999","journal-title":"Nature"},{"key":"2025030702130533100_r11","doi-asserted-by":"crossref","first-page":"428","DOI":"10.3324\/haematol.13412","article-title":"Increased CD4+ and CD8+ effector memory T cells in patients with aplastic anemia","volume":"94","author":"Hu","year":"2009","journal-title":"Haematologica"},{"key":"2025030702130533100_r12","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1038\/nm.2446","article-title":"A human memory T cell subset with stem cell-like properties","volume":"17","author":"Gattinoni","year":"2011","journal-title":"Nat. Med."},{"key":"2025030702130533100_r13","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.immuni.2014.07.003","article-title":"Memory T cells officially join the stem cell club","volume":"41","author":"Gattinoni","year":"2014","journal-title":"Immunity"},{"key":"2025030702130533100_r14","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1182\/blood.V70.6.1718.1718","article-title":"Incidence of aplastic anemia: the relevance of diagnostic criteria. By the International Agranulocytosis and Aplastic Anemia Study","volume":"70","year":"1987","journal-title":"Blood"},{"key":"2025030702130533100_r15","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1182\/blood.V48.1.63.63","article-title":"Severe aplastic anemia: a prospective study of the effect of early marrow transplantation on acute mortality","volume":"48","author":"Camitta","year":"1976","journal-title":"Blood"},{"key":"2025030702130533100_r16","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1002\/art.1780400928","article-title":"Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus","volume":"40","author":"Hochberg","year":"1997","journal-title":"Arthritis Rheum."},{"key":"2025030702130533100_r17","first-page":"288","article-title":"Systemic lupus erythematosus disease activity index 2000","volume":"29","author":"Gladman","year":"2002","journal-title":"J. Rheumatol."},{"key":"2025030702130533100_r18","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nprot.2012.143","article-title":"Identification, isolation and in vitro expansion of human and nonhuman primate T stem cell memory cells","volume":"8","author":"Lugli","year":"2013","journal-title":"Nat. Protoc."},{"key":"2025030702130533100_r19","doi-asserted-by":"crossref","first-page":"455","DOI":"10.3389\/fimmu.2013.00455","article-title":"Inhibitory Receptor Expression Depends More Dominantly on Differentiation and Activation than \u201cExhaustion\u201d of Human CD8 T Cells","volume":"4","author":"Legat","year":"2013","journal-title":"Front. Immunol."},{"key":"2025030702130533100_r20","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1097\/00043426-199024000-00005","article-title":"Immunosuppressive therapy for aplastic anemia: indications, agents, mechanisms, and results","volume":"12","author":"Camitta","year":"1990","journal-title":"Am. J. Pediatr. Hematol. Oncol."},{"key":"2025030702130533100_r21","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1080\/08820130902912332","article-title":"Soluble PD-1 is associated with aberrant regulation of T cells activation in aplastic anemia","volume":"38","author":"Wu","year":"2009","journal-title":"Immunol. Invest."},{"key":"2025030702130533100_r22","doi-asserted-by":"crossref","first-page":"950903","DOI":"10.1155\/2014\/950903","article-title":"Upregulated PD-1 Expression Is Associated with the Development of Systemic Lupus Erythematosus, but Not the PD-1.1 Allele of the PDCD1 Gene","volume":"2014","author":"Jiao","year":"2014","journal-title":"Int. J. Genomics"},{"key":"2025030702130533100_r23","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.autrev.2013.05.003","article-title":"Recent insights into the role of the PD-1\/PD-L1 pathway in immunological tolerance and autoimmunity","volume":"12","author":"Gianchecchi","year":"2013","journal-title":"Autoimmun. Rev."},{"key":"2025030702130533100_r24","doi-asserted-by":"crossref","first-page":"e36046","DOI":"10.1371\/journal.pone.0036046","article-title":"Distinct effector memory CD4+ T cell signatures in latent Mycobacterium tuberculosis infection, BCG vaccination and clinically resolved tuberculosis","volume":"7","author":"Adekambi","year":"2012","journal-title":"PLoS One"},{"key":"2025030702130533100_r25","doi-asserted-by":"crossref","first-page":"5407","DOI":"10.1038\/ncomms6407","article-title":"Progressive contraction of the latent HIV reservoir around a core of less-differentiated CD4\u207a memory T Cells","volume":"5","author":"Jaafoura","year":"2014","journal-title":"Nat. Commun."},{"key":"2025030702130533100_r26","doi-asserted-by":"crossref","first-page":"e30852","DOI":"10.1371\/journal.pone.0030852","article-title":"Extended co-expression of inhibitory receptors by human CD8 T-cells depending on differentiation, antigen-specificity and anatomical localization","volume":"7","author":"Baitsch","year":"2012","journal-title":"PLoS One"},{"key":"2025030702130533100_r27","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1182\/blood-2012-09-457531","article-title":"T cells from CLL patients exhibit features of T-cell exhaustion but retain capacity for cytokine production","volume":"121","author":"Riches","year":"2013","journal-title":"Blood"},{"key":"2025030702130533100_r28","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s00281-014-0433-9","article-title":"Autoimmune and autoinflammatory mechanisms in uveitis","volume":"36","author":"Lee","year":"2014","journal-title":"Semin. Immunopathol."},{"key":"2025030702130533100_r29","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.autrev.2010.09.007","article-title":"Updating on the pathogenesis of systemic lupus erythematosus","volume":"10","author":"Gualtierotti","year":"2010","journal-title":"Autoimmun. Rev."},{"key":"2025030702130533100_r30","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1742-4933-11-14","article-title":"Age-related differences in polyfunctional T cell responses","volume":"11","author":"Van Epps","year":"2014","journal-title":"Immun. Ageing"},{"key":"2025030702130533100_r31","doi-asserted-by":"crossref","first-page":"e3432","DOI":"10.1371\/journal.pntd.0003432","article-title":"Low frequency of circulating CD8+ T stem cell memory cells in chronic chagasic patients with severe forms of the disease","volume":"9","author":"Mateus","year":"2015","journal-title":"PLoS Negl. Trop. Dis."},{"key":"2025030702130533100_r32","doi-asserted-by":"crossref","first-page":"e1004345","DOI":"10.1371\/journal.ppat.1004345","article-title":"Limited HIV infection of central memory and stem cell memory CD4+ T cells is associated with lack of progression in viremic individuals","volume":"10","author":"Klatt","year":"2014","journal-title":"PLoS Pathog."},{"key":"2025030702130533100_r33","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1182\/blood-2012-11-468660","article-title":"Moving T memory stem cells to the clinic","volume":"121","author":"Gattinoni","year":"2013","journal-title":"Blood"},{"key":"2025030702130533100_r34","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.1038\/cti.2014.16","article-title":"Stem memory T cells (TSCM)-their role in cancer and HIV immunotherapies","volume":"3","author":"Flynn","year":"2014","journal-title":"Clin. Transl. Immunology"},{"key":"2025030702130533100_r35","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1182\/blood-2014-11-608539","article-title":"Generation of human memory stem T cells after haploidentical T-replete hematopoietic stem cell transplantation","volume":"125","author":"Cieri","year":"2015","journal-title":"Blood"},{"key":"2025030702130533100_r36","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1182\/blood-2014-11-608406","article-title":"Role of naive-derived T memory stem cells in T-cell reconstitution following allogeneic transplantation","volume":"125","author":"Roberto","year":"2015","journal-title":"Blood"},{"key":"2025030702130533100_r37","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.1182\/blood-2014-10-607465","article-title":"T memory stem cells are the hierarchical apex of adult T-cell leukemia","volume":"125","author":"Nagai","year":"2015","journal-title":"Blood"},{"key":"2025030702130533100_r38","first-page":"594","article-title":"Superior T memory stem cell persistence supports long-lived T cell memory","volume":"123","author":"Lugli","year":"2013","journal-title":"J. Clin. Invest."},{"key":"2025030702130533100_r39","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1196\/annals.1422.005","article-title":"Blood concentrations of hydroxychloroquine and its desethyl derivative correlate negatively with the percentage of CD45RO+ cells among CD4+ lymphocytes in hydroxychloroquine-treated lupus patients","volume":"1108","author":"Sailler","year":"2007","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"2025030702130533100_r40","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1182\/blood-2011-08-368308","article-title":"Functional characterization of CD4+ T cells in aplastic anemia","volume":"119","author":"Kordasti","year":"2012","journal-title":"Blood"},{"key":"2025030702130533100_r41","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1182\/blood-2007-01-066258","article-title":"Deficient CD4+ CD25+ FOXP3+ T regulatory cells in acquired aplastic anemia","volume":"110","author":"Solomou","year":"2007","journal-title":"Blood"},{"key":"2025030702130533100_r42","doi-asserted-by":"crossref","first-page":"4175","DOI":"10.1182\/blood-2010-01-266098","article-title":"Th17 immune responses contribute to the pathophysiology of aplastic anemia","volume":"116","author":"de Latour","year":"2010","journal-title":"Blood"},{"key":"2025030702130533100_r43","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1001\/archophthalmol.2009.32","article-title":"CD4+Foxp3+ T-regulatory cells in noninfectious uveitis","volume":"127","author":"Yeh","year":"2009","journal-title":"Arch. Ophthalmol."},{"key":"2025030702130533100_r44","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/nm1585","article-title":"TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27\/STAT1","volume":"13","author":"Amadi-Obi","year":"2007","journal-title":"Nat. Med."},{"key":"2025030702130533100_r45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clim.2014.05.004","article-title":"Emerging role of IL-17 and Th17 cells in systemic lupus erythematosus","volume":"154","author":"Martin","year":"2014","journal-title":"Clin. Immunol."},{"key":"2025030702130533100_r46","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1136\/ard.2005.044974","article-title":"Decrease of regulatory T cells in patients with systemic lupus erythematosus","volume":"65","author":"Mellor-Pita","year":"2006","journal-title":"Ann. Rheum. Dis."},{"key":"2025030702130533100_r47","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1097\/BOR.0b013e328349a255","article-title":"Effector T-cell subsets in systemic lupus erythematosus: update focusing on Th17 cells","volume":"23","author":"Shin","year":"2011","journal-title":"Curr. Opin. Rheumatol."},{"key":"2025030702130533100_r48","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1046\/j.1365-2567.2003.01750.x","article-title":"Resting CD8 T cells recognize beta-galactosidase expressed in the immune-privileged retina and mediate autoimmune disease when activated","volume":"110","author":"McPherson","year":"2003","journal-title":"Immunology"},{"key":"2025030702130533100_r49","first-page":"255","article-title":"Effects of CD8 depletion on retinal soluble antigen induced experimental autoimmune uveoretinitis","volume":"79","author":"Calder","year":"1993","journal-title":"Immunology"},{"key":"2025030702130533100_r50","doi-asserted-by":"crossref","first-page":"419029","DOI":"10.1155\/2014\/419029","article-title":"The pathology of T cells in systemic lupus erythematosus","volume":"2014","author":"Mak","year":"2014","journal-title":"J. Immunol. Res."},{"key":"2025030702130533100_r51","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.coi.2013.03.003","article-title":"Manipulating the PD-1 pathway to improve immunity","volume":"25","author":"Kamphorst","year":"2013","journal-title":"Curr. Opin. Immunol."},{"key":"2025030702130533100_r52","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3109\/03009742.2013.869830","article-title":"Increased percentages of PD-1 on CD4+ T cells is associated with higher INF-\u03b3 production and altered IL-17 production in patients with systemic lupus erythematosus","volume":"43","author":"Dolff","year":"2014","journal-title":"Scand. J. Rheumatol."},{"key":"2025030702130533100_r53","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1158\/1078-0432.CCR-06-2599","article-title":"PD-1 is expressed by tumor-infiltrating immune cells and is associated with poor outcome for patients with renal cell carcinoma","volume":"13","author":"Thompson","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"2025030702130533100_r54","doi-asserted-by":"crossref","first-page":"5094","DOI":"10.1158\/1078-0432.CCR-04-0428","article-title":"B7-H1 expression on non-small cell lung cancer cells and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression","volume":"10","author":"Konishi","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"2025030702130533100_r55","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1172\/JCI73639","article-title":"PD-1 identifies the patient-specific CD8+ tumor-reactive repertoire infiltrating human tumors","volume":"124","author":"Gros","year":"2014","journal-title":"J. Clin. Invest."},{"key":"2025030702130533100_r56","doi-asserted-by":"crossref","first-page":"4200","DOI":"10.4049\/jimmunol.1001783","article-title":"Phenotype, function, and gene expression profiles of programmed death-1(hi) CD8 T cells in healthy human adults","volume":"186","author":"Duraiswamy","year":"2011","journal-title":"J. Immunol."},{"key":"2025030702130533100_r57","doi-asserted-by":"crossref","first-page":"3668","DOI":"10.1182\/blood.V99.10.3668","article-title":"Changes in T-cell receptor VB repertoire in aplastic anemia: effects of different immunosuppressive regimens","volume":"99","author":"Kook","year":"2002","journal-title":"Blood"},{"key":"2025030702130533100_r58","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/bjh.13123","article-title":"Red blood cell alloimmunization is influenced by recipient inflammatory state at time of transfusion in patients with sickle cell disease","volume":"168","author":"Fasano","year":"2015","journal-title":"Br. J. Haematol."},{"key":"2025030702130533100_r59","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1161\/01.ATV.0000220374.00602.a2","article-title":"Biologically active CD40 ligand is elevated in sickle cell anemia: potential role for platelet-mediated inflammation","volume":"26","author":"Lee","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/196\/4\/1568\/62257177\/1501739.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/196\/4\/1568\/62257177\/1501739.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T02:21:30Z","timestamp":1741314090000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/196\/4\/1568\/7961541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":59,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,2,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1501739","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2016,2]]},"published":{"date-parts":[[2016,2]]}}}