{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T22:48:11Z","timestamp":1775515691185,"version":"3.50.1"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>C-type lectin receptors (CLRs), the carbohydrate-recognizing molecules, orchestrate host immune response in homeostasis and in inflammation. In the present study we examined the function of macrophage galactose-type lectin-1 (MGL1), a mammalian CLR, in pneumonic sepsis, a deadly immune disorder frequently associated with a nonresolving hyperinflammation. In a murine model of pneumonic sepsis using pulmonary infection with Klebsiella pneumoniae, the expression of MGL1 was upregulated in the lungs of K. pneumoniae\u2013infected mice, and the deficiency of this CLR in MGL1\u2212\/\u2212 mice resulted in significantly increased mortality to infection than in the MGL1-sufficient wild-type mice, despite a similar bacterial burden. The phagocytic cells from MGL1\u2212\/\u2212 mice did not exhibit any defects in bacterial uptake and intracellular killing and were fully competent in neutrophil extracellular trap formation, a recently identified extracellular killing modality of neutrophils. Instead, the increased susceptibility of MGL1\u2212\/\u2212 mice seemed to correlate with severe lung pathology, indicating that MGL1 is required for resolution of pulmonary inflammation. Indeed, the MGL1\u2212\/\u2212 mice exhibited a hyperinflammatory response, massive pulmonary neutrophilia, and an increase in neutrophil-associated immune mediators. Concomitantly, MGL1-deficient neutrophils exhibited an increased influx in pneumonic lungs of K. pneumoniae\u2013infected mice. Taken together, these results show a previously undetermined role of MGL1 in controlling neutrophilia during pneumonic infection, thus playing an important role in resolution of inflammation. To our knowledge, this is the first study depicting a protective function of MGL1 in an acute pneumonic bacterial infection.<\/jats:p>","DOI":"10.4049\/jimmunol.1501790","type":"journal-article","created":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T04:31:58Z","timestamp":1456374718000},"page":"3088-3096","source":"Crossref","is-referenced-by-count":25,"title":["Macrophage Galactose-Type Lectin-1 Deficiency Is Associated with Increased Neutrophilia and Hyperinflammation in Gram-Negative Pneumonia"],"prefix":"10.1093","volume":"196","author":[{"given":"Christopher N","family":"Jondle","sequence":"first","affiliation":[{"name":"Department of Basic Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences , Grand Forks, ND 58202"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atul","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Basic Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences , Grand Forks, ND 58202"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanner J","family":"Simonson","sequence":"additional","affiliation":[{"name":"Department of Basic Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences , Grand Forks, ND 58202"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1940-9565","authenticated-orcid":false,"given":"Benjamin","family":"Larson","sequence":"additional","affiliation":[{"name":"Department of Basic Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences , Grand Forks, ND 58202"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bibhuti B","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Basic Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences , Grand Forks, ND 58202"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyotika","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Basic Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences , Grand Forks, ND 58202"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,4,1]]},"reference":[{"key":"2025030702152263300_r1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/s10156-008-0596-1","article-title":"Pathogen recognition by innate receptors","volume":"14","author":"Kumagai","year":"2008","journal-title":"J. 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