{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:58:15Z","timestamp":1790661495288,"version":"4.1.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Alopecia areata (AA) is an autoimmune disease of the hair follicle that results in hair loss of varying severity. Recently, we showed that IFN-\u03b3\u2013producing NKG2D+CD8+ T cells actively infiltrate the hair follicle and are responsible for its destruction in C3H\/HeJ AA mice. Our transcriptional profiling of human and mouse alopecic skin showed that the IFN pathway is the dominant signaling pathway involved in AA. We showed that IFN-inducible chemokines (CXCL9\/10\/11) are markedly upregulated in the skin of AA lesions, and further, that the IFN-inducible chemokine receptor, CXCR3, is upregulated on alopecic effector T cells. To demonstrate whether CXCL9\/10\/11 chemokines were required for development of AA, we treated mice with blocking Abs to CXCR3, which prevented the development of AA in the graft model, inhibiting the accumulation of NKG2D+CD8+ T cells in the skin and cutaneous lymph nodes. These data demonstrate proof of concept that interfering with the Tc1 response in AA via blockade of IFN-inducible chemokines can prevent the onset of AA. CXCR3 blockade could be approached clinically in human AA with either biologic or small-molecule inhibition, the latter being particularly intriguing as a topical therapeutic.<\/jats:p>","DOI":"10.4049\/jimmunol.1501798","type":"journal-article","created":{"date-parts":[[2016,7,14]],"date-time":"2016-07-14T06:52:18Z","timestamp":1468479138000},"page":"1089-1099","source":"Crossref","is-referenced-by-count":80,"title":["CXCR3 Blockade Inhibits T Cell Migration into the Skin and Prevents Development of Alopecia Areata"],"prefix":"10.1093","volume":"197","author":[{"given":"Zhenpeng","family":"Dai","sequence":"first","affiliation":[{"name":"Department of Dermatology, College of Physicians and Surgeons, Columbia University , New York, NY 10032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luzhou","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Pathology, Columbia University , New York, NY 10032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8568-1383","authenticated-orcid":false,"given":"Jane","family":"Cerise","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Physicians and Surgeons, Columbia University , New York, NY 10032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7785-1442","authenticated-orcid":false,"given":"Eddy Hsi Chun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Physicians and Surgeons, Columbia University , New York, NY 10032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Jabbari","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Physicians and Surgeons, Columbia University , New York, NY 10032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6707-6585","authenticated-orcid":false,"given":"Annemieke","family":"de Jong","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Physicians and Surgeons, Columbia University , New York, NY 10032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Petukhova","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Physicians and Surgeons, Columbia University , New York, NY 10032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela M","family":"Christiano","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Physicians and Surgeons, Columbia University , New York, NY 10032"},{"name":"Department of Genetics and Development, College of Physicians and Surgeons, Columbia University , New York, NY 10032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7963-8482","authenticated-orcid":false,"given":"Raphael","family":"Clynes","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Physicians and Surgeons, Columbia University , New York, NY 10032"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,8,15]]},"reference":[{"key":"2025030617474141400_r1","doi-asserted-by":"crossref","first-page":"628","DOI":"10.4065\/70.7.628","article-title":"Incidence of alopecia areata in Olmsted County, Minnesota, 1975 through 1989","volume":"70","author":"Safavi","year":"1995","journal-title":"Mayo Clin. 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