{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:20:42Z","timestamp":1791199242619,"version":"4.1.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature myeloid cells that promote tumor progression. In this study, we demonstrated that activation of a C-type lectin receptor, dectin-1, in MDSC differentially modulates the function of different MDSC subsets. Yeast-derived whole \u03b2-glucan particles (WGP; a ligand to engage and activate dectin-1, oral treatment in vivo) significantly decreased tumor weight and splenomegaly in tumor-bearing mice with reduced accumulation of polymorphonuclear MDSC but not monocytic MDSC (M-MDSC), and decreased polymorphonuclear MDSC suppression in vitro through the induction of respiratory burst and apoptosis. On a different axis, WGP-treated M-MDSC differentiated into F4\/80+CD11c+ cells in vitro that served as potent APC to induce Ag-specific CD4+ and CD8+ T cell responses in a dectin-1\u2013dependent manner. Additionally, Erk1\/2 phosphorylation was required for the acquisition of APC properties in M-MDSC. Moreover, WGP-treated M-MDSC differentiated into CD11c+ cells in vivo with high MHC class II expression and induced decreased tumor burden when inoculated s.c. with Lewis lung carcinoma cells. This effect was dependent on the dectin-1 receptor. Strikingly, patients with non\u2013small cell lung carcinoma that had received WGP treatment for 10\u201314 d prior to any other treatment had a decreased frequency of CD14\u2212HLA-DR\u2212CD11b+CD33+ MDSC in the peripheral blood. Overall, these data indicate that WGP may be a potent immune modulator of MDSC suppressive function and differentiation in cancer.<\/jats:p>","DOI":"10.4049\/jimmunol.1501853","type":"journal-article","created":{"date-parts":[[2016,1,26]],"date-time":"2016-01-26T03:58:09Z","timestamp":1453780689000},"page":"2167-2180","source":"Crossref","is-referenced-by-count":105,"title":["Yeast-Derived Particulate \u03b2-Glucan Treatment Subverts the Suppression of Myeloid-Derived Suppressor Cells (MDSC) by Inducing Polymorphonuclear MDSC Apoptosis and Monocytic MDSC Differentiation to APC in Cancer"],"prefix":"10.1093","volume":"196","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9708-6810","authenticated-orcid":false,"given":"Sabrin H","family":"Albeituni","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of Louisville , Louisville, KY 40202"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanlin","family":"Ding","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology, Department of Medicine, James Graham Brown Cancer Center, University of Louisville , Louisville, KY 40202"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7095-1344","authenticated-orcid":false,"given":"Min","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology, Department of Medicine, James Graham Brown Cancer Center, University of Louisville , Louisville, KY 40202"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Hu","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology, Department of Medicine, James Graham Brown Cancer Center, University of Louisville , Louisville, KY 40202"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengling","family":"Luo","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology, Department of Medicine, James Graham Brown Cancer Center, University of Louisville , Louisville, KY 40202"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goetz","family":"Kloecker","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology, Department of Medicine, James Graham Brown Cancer Center, University of Louisville , Louisville, KY 40202"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"II","given":"Michael","family":"Bousamra","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department of Cardiovascular and Thoracic Surgery, University of Louisville , Louisville, KY 40202"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huang-ge","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Louisville , Louisville, KY 40202"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Louisville , Louisville, KY 40202"},{"name":"Division of Hematology and Medical Oncology, Department of Medicine, James Graham Brown Cancer Center, University of Louisville , Louisville, KY 40202"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,3,1]]},"reference":[{"key":"2025030702140792400_r1","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/ni1102-991","article-title":"Cancer immunoediting: from immunosurveillance to tumor escape","volume":"3","author":"Dunn","year":"2002","journal-title":"Nat. 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