{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T20:48:21Z","timestamp":1783975701611,"version":"3.55.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"vor","delay-in-days":3078,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Pattern recognition receptors detect microbial products and induce cytokines, which shape the immunological response. IL-12, TNF-\u03b1, and IL-1\u03b2 are proinflammatory cytokines, which are essential for resistance against infection, but when produced at high levels they may contribute to immunopathology. In contrast, IL-10 is an immunosuppressive cytokine, which dampens proinflammatory responses, but it can also lead to defective pathogen clearance. The regulation of these cytokines is therefore central to the generation of an effective but balanced immune response. In this study, we show that macrophages derived from C57BL\/6 mice produce low levels of IL-12, TNF-\u03b1, and IL-1\u03b2, but high levels of IL-10, in response to TLR4 and TLR2 ligands LPS and Pam3CSK4, as well as Burkholderia pseudomallei, a Gram-negative bacterium that activates TLR2\/4. In contrast, macrophages derived from BALB\/c mice show a reciprocal pattern of cytokine production. Differential production of IL-10 in B. pseudomallei and LPS-stimulated C57BL\/6 and BALB\/c macrophages was due to a type I IFN and ERK1\/2-dependent, but IL-27\u2013independent, mechanism. Enhanced type I IFN expression in LPS-stimulated C57BL\/6 macrophages was accompanied by increased STAT1 and IFN regulatory factor 3 activation. Furthermore, type I IFN contributed to differential IL-1\u03b2 and IL-12 production in B. pseudomallei and LPS-stimulated C57BL\/6 and BALB\/c macrophages via both IL-10\u2013dependent and \u2013independent mechanisms. These findings highlight key pathways responsible for the regulation of pro- and anti-inflammatory cytokines in macrophages and reveal how they may differ according to the genetic background of the host.<\/jats:p>","DOI":"10.4049\/jimmunol.1501923","type":"journal-article","created":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T02:38:55Z","timestamp":1471919935000},"page":"2838-2853","source":"Crossref","is-referenced-by-count":39,"title":["Differential Production of Type I IFN Determines the Reciprocal Levels of IL-10 and Proinflammatory Cytokines Produced by C57BL\/6 and BALB\/c Macrophages"],"prefix":"10.1093","volume":"197","author":[{"given":"Ashleigh","family":"Howes","sequence":"first","affiliation":[{"name":"Laboratory of Immunoregulation and Infection, The Francis Crick Institute, Mill Hill Laboratory , London NW7 1AA,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Taubert","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoregulation and Infection, The Francis Crick Institute, Mill Hill Laboratory , London NW7 1AA,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Blankley","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoregulation and Infection, The Francis Crick Institute, Mill Hill Laboratory , London NW7 1AA,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Spink","sequence":"additional","affiliation":[{"name":"London School of Hygiene and Tropical Medicine , London WC1E 7HT,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Wu","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoregulation and Infection, The Francis Crick Institute, Mill Hill Laboratory , London NW7 1AA,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine M","family":"Graham","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoregulation and Infection, The Francis Crick Institute, Mill Hill Laboratory , London NW7 1AA,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Research and Innovation, Neo-Life Stem Cell Biotech Inc., Sichuan Umbilical Cord Blood Bank , Chengdu, Sichuan 610036,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarida","family":"Saraiva","sequence":"additional","affiliation":[{"name":"Life and Health Sciences Research Institute, School of Health Sciences, University of Minho , 4710-057 Braga,","place":["Portugal"]},{"name":"Life and Health Sciences Research Institute, Biomaterials, Biodegradables and Biomimetics, Portuguese Government Associate Laboratory , 4710-057 Braga\/Guimar\u00e3es,","place":["Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4749-7187","authenticated-orcid":false,"given":"Paola","family":"Ricciardi-Castagnoli","sequence":"additional","affiliation":[{"name":"Singapore Immunology Network, Agency for Science, Technology and Research , Singapore 138632,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7243-679X","authenticated-orcid":false,"given":"Gregory J","family":"Bancroft","sequence":"additional","affiliation":[{"name":"London School of Hygiene and Tropical Medicine , London WC1E 7HT,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9845-6134","authenticated-orcid":false,"given":"Anne","family":"O\u2019Garra","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoregulation and Infection, The Francis Crick Institute, Mill Hill Laboratory , London NW7 1AA,","place":["United Kingdom"]},{"name":"Department of Medicine, National Heart and Lung Institute, Imperial College London , London SW3 6LY,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,10,1]]},"reference":[{"key":"2025030617524684300_r1","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/ni.2391","article-title":"Restraint of inflammatory signaling by interdependent strata of negative regulatory pathways","volume":"13","author":"Murray","year":"2012","journal-title":"Nat. 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Immunol."},{"key":"2025030617524684300_r16","doi-asserted-by":"crossref","first-page":"3600","DOI":"10.4049\/jimmunol.1401088","article-title":"Type I IFN induces IL-10 production in an IL-27-independent manner and blocks responsiveness to IFN-\u03b3 for production of IL-12 and bacterial killing in Mycobacterium tuberculosis-infected macrophages","volume":"193","author":"McNab","year":"2014","journal-title":"J. Immunol."},{"key":"2025030617524684300_r17","doi-asserted-by":"crossref","first-page":"4298","DOI":"10.4049\/jimmunol.160.9.4298","article-title":"Type I IFNs inhibit human dendritic cell IL-12 production and Th1 cell development","volume":"160","author":"McRae","year":"1998","journal-title":"J. Immunol."},{"key":"2025030617524684300_r18","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1084\/jem.20041964","article-title":"A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells","volume":"201","author":"Gautier","year":"2005","journal-title":"J. Exp. Med."},{"key":"2025030617524684300_r19","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1073\/pnas.94.2.634","article-title":"Interferon-\u03b1\/\u03b2 inhibition of interleukin 12 and interferon-\u03b3 production in vitro and endogenously during viral infection","volume":"94","author":"Cousens","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030617524684300_r20","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nri3787","article-title":"Type I interferons in infectious disease","volume":"15","author":"McNab","year":"2015","journal-title":"Nat. Rev. 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Microbiol."},{"key":"2025030617524684300_r23","doi-asserted-by":"crossref","first-page":"3512","DOI":"10.4049\/jimmunol.162.6.3512","article-title":"Inhibition of inducible nitric oxide synthase exacerbates chronic cerebral toxoplasmosis in Toxoplasma gondii-susceptible C57BL\/6 mice but does not reactivate the latent disease in T. gondii-resistant BALB\/c mice","volume":"162","author":"Schl\u00fcter","year":"1999","journal-title":"J. Immunol."},{"key":"2025030617524684300_r24","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/nrmicro1385","article-title":"Melioidosis: insights into the pathogenicity of Burkholderia pseudomallei","volume":"4","author":"Wiersinga","year":"2006","journal-title":"Nat. Rev. Microbiol."},{"key":"2025030617524684300_r25","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1086\/315271","article-title":"Prognostic value of cytokine concentrations (tumor necrosis factor-\u03b1, interleukin-6, and interleukin-10) and clinical parameters in severe melioidosis","volume":"181","author":"Simpson","year":"2000","journal-title":"J. Infect. Dis."},{"key":"2025030617524684300_r26","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1006\/mpat.1997.0179","article-title":"BALB\/c and C57Bl\/6 mice infected with virulent Burkholderia pseudomallei provide contrasting animal models for the acute and chronic forms of human melioidosis","volume":"24","author":"Leakey","year":"1998","journal-title":"Microb. Pathog."},{"key":"2025030617524684300_r27","doi-asserted-by":"crossref","first-page":"S111","DOI":"10.1016\/S0035-9203(08)70026-9","article-title":"Burkholderia pseudomallei: animal models of infection","volume":"102","author":"Titball","year":"2008","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"2025030617524684300_r28","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1099\/jmm.0.47596-0","article-title":"Burkholderia pseudomallei aerosol infection results in differential inflammatory responses in BALB\/c and C57Bl\/6 mice","volume":"57","author":"Tan","year":"2008","journal-title":"J. Med. Microbiol."},{"key":"2025030617524684300_r29","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1128\/IAI.68.4.2034-2042.2000","article-title":"Cytokine gene expression in innately susceptible BALB\/c mice and relatively resistant C57BL\/6 mice during infection with virulent Burkholderia pseudomallei","volume":"68","author":"Ulett","year":"2000","journal-title":"Infect. Immun."},{"key":"2025030617524684300_r30","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0001-706X(99)00075-3","article-title":"Proinflammatory cytokine mRNA responses in experimental Burkholderia pseudomallei infection in mice","volume":"74","author":"Ulett","year":"2000","journal-title":"Acta Trop."},{"key":"2025030617524684300_r31","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1128\/IAI.70.2.504-511.2002","article-title":"Model of differential susceptibility to mucosal Burkholderia pseudomallei infection","volume":"70","author":"Liu","year":"2002","journal-title":"Infect. 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J."},{"key":"2025030617524684300_r35","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1084\/jem.20091059","article-title":"TPL-2 negatively regulates interferon-\u03b2 production in macrophages and myeloid dendritic cells","volume":"206","author":"Kaiser","year":"2009","journal-title":"J. Exp. Med."},{"key":"2025030617524684300_r36","doi-asserted-by":"crossref","first-page":"e248","DOI":"10.1371\/journal.pmed.0040248","article-title":"Toll-like receptor 2 impairs host defense in gram-negative sepsis caused by Burkholderia pseudomallei (Melioidosis)","volume":"4","author":"Wiersinga","year":"2007","journal-title":"PLoS Med."},{"key":"2025030617524684300_r37","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1086\/587905","article-title":"Interleukin-8 induction by Burkholderia pseudomallei can occur without Toll-like receptor signaling but requires a functional type III secretion system","volume":"197","author":"Hii","year":"2008","journal-title":"J. Infect. Dis."},{"key":"2025030617524684300_r38","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/1471-2172-9-46","article-title":"Activation of Toll-like receptors by Burkholderia pseudomallei","volume":"9","author":"West","year":"2008","journal-title":"BMC Immunol."},{"key":"2025030617524684300_r39","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1084\/jem.170.3.827","article-title":"Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes","volume":"170","author":"Kobayashi","year":"1989","journal-title":"J. Exp. Med."},{"key":"2025030617524684300_r40","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1093\/intimm\/dxh318","article-title":"Regulation of the type I IFN induction: a current view","volume":"17","author":"Honda","year":"2005","journal-title":"Int. Immunol."},{"key":"2025030617524684300_r41","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.4049\/jimmunol.1200310","article-title":"Inhibition of JAKs in macrophages increases lipopolysaccharide-induced cytokine production by blocking IL-10-mediated feedback","volume":"189","author":"Pattison","year":"2012","journal-title":"J. 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Immunol."},{"key":"2025030617524684300_r44","doi-asserted-by":"crossref","first-page":"6325","DOI":"10.4049\/jimmunol.180.9.6325","article-title":"IL-27 activates human monocytes via STAT1 and suppresses IL-10 production but the inflammatory functions of IL-27 are abrogated by TLRs and p38","volume":"180","author":"Kalliolias","year":"2008","journal-title":"J. Immunol."},{"key":"2025030617524684300_r45","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.4049\/jimmunol.0902005","article-title":"Critical role of the IFN-stimulated gene factor 3 complex in TLR-mediated IL-27p28 gene expression revealing a two-step activation process","volume":"184","author":"Molle","year":"2010","journal-title":"J. Immunol."},{"key":"2025030617524684300_r46","first-page":"157","article-title":"The regulation of IL-10 expression","volume":"380","author":"Gabry\u0161ov\u00e1","year":"2014","journal-title":"Curr. Top. Microbiol. 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Immunol."},{"key":"2025030617524684300_r49","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1038\/ni.1640","article-title":"The kinase p38\u03b1 serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression","volume":"9","author":"Kim","year":"2008","journal-title":"Nat. Immunol."},{"key":"2025030617524684300_r50","doi-asserted-by":"crossref","first-page":"13664","DOI":"10.1074\/jbc.M011157200","article-title":"The p38 mitogen-activated kinase pathway regulates the human interleukin-10 promoter via the activation of Sp1 transcription factor in lipopolysaccharide-stimulated human macrophages","volume":"276","author":"Ma","year":"2001","journal-title":"J. Biol. Chem."},{"key":"2025030617524684300_r51","doi-asserted-by":"crossref","first-page":"4711","DOI":"10.4049\/jimmunol.168.9.4711","article-title":"Role of mitogen-activated protein kinases in CpG DNA-mediated IL-10 and IL-12 production: central role of extracellular signal-regulated kinase in the negative feedback loop of the CpG DNA-mediated Th1 response","volume":"168","author":"Yi","year":"2002","journal-title":"J. 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