{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T05:24:55Z","timestamp":1784697895471,"version":"3.55.0"},"reference-count":84,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Chronic beryllium (Be) disease is a granulomatous lung disorder that results from Be exposure in a genetically susceptible host. The disease is characterized by the accumulation of Be-responsive CD4+ T cells in the lung, and genetic susceptibility is primarily linked to HLA \u00a0-DPB1 alleles possessing a glutamic acid at position 69 of the \u03b2-chain. Recent structural analysis of a Be-specific TCR interacting with a Be-loaded HLA-DP2\u2013peptide complex revealed that Be is coordinated by amino acid residues derived from the HLA-DP2 \u03b2-chain and peptide and showed that the TCR does not directly interact with the Be2+ cation. Rather, the TCR recognizes a modified HLA-DP2\u2013peptide complex with charge and conformational changes. Collectively, these findings provide a structural basis for the development of this occupational lung disease through the ability of Be to induce posttranslational modifications in preexisting HLA-DP2\u2013peptide complexes, resulting in the creation of neoantigens.<\/jats:p>","DOI":"10.4049\/jimmunol.1502011","type":"journal-article","created":{"date-parts":[[2015,12,18]],"date-time":"2015-12-18T21:37:21Z","timestamp":1450474641000},"page":"22-27","source":"Crossref","is-referenced-by-count":54,"title":["Beryllium-Induced Hypersensitivity: Genetic Susceptibility and Neoantigen Generation"],"prefix":"10.1093","volume":"196","author":[{"given":"Andrew P","family":"Fontenot","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Colorado Anschutz Medical Campus , Aurora, CO 80045"},{"name":"Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus , Aurora, CO 80045"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0835-6904","authenticated-orcid":false,"given":"Michael T","family":"Falta","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Colorado Anschutz Medical Campus , Aurora, CO 80045"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W","family":"Kappler","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus , Aurora, CO 80045"},{"name":"Howard Hughes Medical Institute, National Jewish Health , Denver, CO 80206"},{"name":"Department of Biomedical Research, National Jewish Health , Denver, CO 80206"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4760-2773","authenticated-orcid":false,"given":"Shaodong","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus , Aurora, CO 80045"},{"name":"Department of Biomedical Research, National Jewish Health , Denver, CO 80206"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy S","family":"McKee","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Colorado Anschutz Medical Campus , Aurora, CO 80045"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,1,1]]},"reference":[{"key":"2025030702111559600_r1","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.1164\/rccm.201409-1722ST","article-title":"An official American Thoracic Society statement: diagnosis and management of beryllium sensitivity and chronic beryllium disease","volume":"190","author":"Balmes","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2025030702111559600_r2","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1080\/15459620490502233","article-title":"Industries in the United States with airborne beryllium exposure and estimates of the number of current workers potentially exposed","volume":"1","author":"Henneberger","year":"2004","journal-title":"J. Occup. Environ. Hyg."},{"key":"2025030702111559600_r3","volume-title":"2013 Minerals Yearbook.","author":"Jaskula","year":"2015"},{"key":"2025030702111559600_r4","first-page":"41","article-title":"Investigation of dust arising out of beryllium extraction","volume":"10","author":"Weber","year":"1933","journal-title":"Gewerbehyg Unfallverhuet."},{"key":"2025030702111559600_r5","first-page":"371","article-title":"Poisoning by vapors of beryllium oxyfluoride","volume":"18","author":"Gelman","year":"1936","journal-title":"J. Ind. Hyg. Toxicol."},{"key":"2025030702111559600_r6","first-page":"117","article-title":"Changes in the lungs by beryllium oxyfluoride","volume":"18","author":"Berkovits","year":"1940","journal-title":"Klin. Med. (Mosk.)"},{"key":"2025030702111559600_r7","first-page":"197","article-title":"Delayed chemical pneumonitis occurring in workers exposed to beryllium compounds","volume":"28","author":"Hardy","year":"1946","journal-title":"J. Ind. Hyg. Toxicol."},{"key":"2025030702111559600_r8","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1164\/rccm.200402-190OC","article-title":"Beryllium sensitization progresses to chronic beryllium disease: a longitudinal study of disease risk","volume":"171","author":"Newman","year":"2005","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2025030702111559600_r9","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1093\/occmed\/kqs069","article-title":"Systematic review: Progression of beryllium sensitization to chronic beryllium disease","volume":"62","author":"Seidler","year":"2012","journal-title":"Occup. Med. (Lond.)"},{"key":"2025030702111559600_r10","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1046\/j.1399-0039.2003.00160.x","article-title":"Chronic beryllium disease: immune-mediated destruction with implications for organ-specific autoimmunity","volume":"62","author":"Fontenot","year":"2003","journal-title":"Tissue Antigens"},{"key":"2025030702111559600_r11","doi-asserted-by":"crossref","first-page":"687","DOI":"10.7326\/0003-4819-108-5-687","article-title":"Proliferative response of bronchoalveolar lymphocytes to beryllium. A test for chronic beryllium disease","volume":"108","author":"Rossman","year":"1988","journal-title":"Ann. Intern. Med."},{"key":"2025030702111559600_r12","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1164\/ajrccm\/139.6.1479","article-title":"Pathologic and immunologic alterations in early stages of beryllium disease. Re-examination of disease definition and natural history","volume":"139","author":"Newman","year":"1989","journal-title":"Am. Rev. Respir. Dis."},{"key":"2025030702111559600_r13","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1056\/NEJM199704243361706","article-title":"Sarcoidosis","volume":"336","author":"Newman","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"2025030702111559600_r14","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1136\/jcp.39.8.900","article-title":"New aid for diagnosing chronic beryllium disease (CBD): laser ion mass analysis (LIMA)","volume":"39","author":"Williams","year":"1986","journal-title":"J. Clin. Pathol."},{"key":"2025030702111559600_r15","first-page":"937","article-title":"The natural history of beryllium sensitization and chronic beryllium disease","volume":"104","author":"Newman","year":"1996","journal-title":"Environ. Health Perspect."},{"key":"2025030702111559600_r16","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/0020-7519(92)90058-S","article-title":"The effect of adjuvant and specific or non-specific vaccination on development of protective immunity of rabbits against Trichostrongylus colubriformis infection","volume":"22","author":"Wedrychowicz","year":"1992","journal-title":"Int. J. Parasitol."},{"key":"2025030702111559600_r17","doi-asserted-by":"crossref","first-page":"4032","DOI":"10.1128\/IAI.68.7.4032-4039.2000","article-title":"Beryllium, an adjuvant that promotes gamma interferon production","volume":"68","author":"Lee","year":"2000","journal-title":"Infect. Immun."},{"key":"2025030702111559600_r18","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.tox.2005.10.016","article-title":"Chemokine regulation in response to beryllium exposure in human peripheral blood mononuclear and dendritic cells","volume":"218","author":"Hong-Geller","year":"2006","journal-title":"Toxicology"},{"key":"2025030702111559600_r19","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1183\/09031936.02.02232001","article-title":"HLA-DP-unrestricted TNF-\u03b1 release in beryllium-stimulated peripheral blood mononuclear cells","volume":"20","author":"Amicosante","year":"2002","journal-title":"Eur. Respir. J."},{"key":"2025030702111559600_r20","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0300-483X(99)00182-1","article-title":"Beryllium-stimulated production of tumor necrosis factor-\u03b1 by a mouse hybrid macrophage cell line","volume":"143","author":"Sawyer","year":"2000","journal-title":"Toxicology"},{"key":"2025030702111559600_r21","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1080\/00039896.1996.9935990","article-title":"Tumor necrosis factor alpha gene expression in human monocytic THP-1 cells exposed to beryllium","volume":"51","author":"Galbraith","year":"1996","journal-title":"Arch. Environ. Health"},{"key":"2025030702111559600_r22","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.freeradbiomed.2004.12.014","article-title":"Beryllium-stimulated reactive oxygen species and macrophage apoptosis","volume":"38","author":"Sawyer","year":"2005","journal-title":"Free Radic. Biol. Med."},{"key":"2025030702111559600_r23","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.humimm.2014.10.010","article-title":"p38 Mitogen-Activated Protein Kinase in beryllium-induced dendritic cell activation","volume":"75","author":"Li","year":"2014","journal-title":"Hum. Immunol."},{"key":"2025030702111559600_r24","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1038\/mi.2015.14","article-title":"MyD88 dependence of beryllium-induced dendritic cell trafficking and CD4(+) T-cell priming","volume":"8","author":"McKee","year":"2015","journal-title":"Mucosal Immunol."},{"key":"2025030702111559600_r25","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.4049\/jimmunol.163.5.2592","article-title":"Intranasal exposure to protein antigen induces immunological tolerance mediated by functionally disabled CD4+ T cells","volume":"163","author":"Tsitoura","year":"1999","journal-title":"J. Immunol."},{"key":"2025030702111559600_r26","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/ni712","article-title":"Toll-like receptors control activation of adaptive immune responses","volume":"2","author":"Schnare","year":"2001","journal-title":"Nat. Immunol."},{"key":"2025030702111559600_r27","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1056\/NEJM198904273201702","article-title":"Maintenance of alveolitis in patients with chronic beryllium disease by beryllium-specific helper T cells","volume":"320","author":"Saltini","year":"1989","journal-title":"N. Engl. J. Med."},{"key":"2025030702111559600_r28","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1084\/jem.171.4.1123","article-title":"Biased accumulation of T lymphocytes with \u201cmemory\u201d-type CD45 leukocyte common antigen gene expression on the epithelial surface of the human lung","volume":"171","author":"Saltini","year":"1990","journal-title":"J. Exp. Med."},{"key":"2025030702111559600_r29","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.4049\/jimmunol.163.2.1019","article-title":"Identification of pathogenic T cells in patients with beryllium-induced lung disease","volume":"163","author":"Fontenot","year":"1999","journal-title":"J. Immunol."},{"key":"2025030702111559600_r30","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1165\/ajrcmb.18.4.2981","article-title":"Expansions of T-cell subsets expressing particular T-cell receptor variable regions in chronic beryllium disease","volume":"18","author":"Fontenot","year":"1998","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2025030702111559600_r31","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1172\/JCI0215846","article-title":"Target organ localization of memory CD4(+) T cells in patients with chronic beryllium disease","volume":"110","author":"Fontenot","year":"2002","journal-title":"J. Clin. Invest."},{"key":"2025030702111559600_r32","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1172\/JCI200318317","article-title":"CD28 costimulation independence of target organ versus circulating memory antigen-specific CD4+ T cells","volume":"112","author":"Fontenot","year":"2003","journal-title":"J. Clin. Invest."},{"key":"2025030702111559600_r33","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.1172\/JCI24908","article-title":"Frequency of beryllium-specific, central memory CD4+ T cells in blood determines proliferative response","volume":"115","author":"Fontenot","year":"2005","journal-title":"J. Clin. Invest."},{"key":"2025030702111559600_r34","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.4049\/jimmunol.180.4.2704","article-title":"Up-regulation of programmed death-1 expression on beryllium-specific CD4+ T cells in chronic beryllium disease","volume":"180","author":"Palmer","year":"2008","journal-title":"J. Immunol."},{"key":"2025030702111559600_r35","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.4049\/jimmunol.1300282","article-title":"Impaired function of CTLA-4 in the lungs of patients with chronic beryllium disease contributes to persistent inflammation","volume":"191","author":"Chain","year":"2013","journal-title":"J. Immunol."},{"key":"2025030702111559600_r36","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/nri727","article-title":"The B7-CD28 superfamily","volume":"2","author":"Sharpe","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"2025030702111559600_r37","doi-asserted-by":"crossref","first-page":"518","DOI":"10.4049\/jimmunol.158.1.518","article-title":"Beryllium induces IL-2 and IFN-\u03b3 in berylliosis","volume":"158","author":"Tinkle","year":"1997","journal-title":"J. Immunol."},{"key":"2025030702111559600_r38","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.jaci.2011.08.022","article-title":"Beryllium-specific CD4+ T cells in blood as a biomarker of disease progression","volume":"128","author":"Martin","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"key":"2025030702111559600_r39","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.jaci.2005.01.019","article-title":"Frequency of beryllium-specific, TH1-type cytokine-expressing CD4+ T cells in patients with beryllium-induced disease","volume":"115","author":"Pott","year":"2005","journal-title":"J. Allergy Clin. Immunol."},{"key":"2025030702111559600_r40","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1126\/science.3317824","article-title":"The T cell receptor","volume":"238","author":"Marrack","year":"1987","journal-title":"Science"},{"key":"2025030702111559600_r41","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1126\/science.288.5469.1135a","article-title":"Diversity of human \u03b1\u03b2 T cell receptors","volume":"288","author":"Arstila","year":"2000","journal-title":"Science"},{"key":"2025030702111559600_r42","doi-asserted-by":"crossref","first-page":"4571","DOI":"10.4049\/jimmunol.1400007","article-title":"Identification of multiple public TCR repertoires in chronic beryllium disease","volume":"192","author":"Bowerman","year":"2014","journal-title":"J. Immunol."},{"key":"2025030702111559600_r43","doi-asserted-by":"crossref","first-page":"128ra42","DOI":"10.1126\/scitranslmed.3003647","article-title":"T cell receptor \u03b1\u03b2 diversity inversely correlates with pathogen-specific antibody levels in human cytomegalovirus infection","volume":"4","author":"Wang","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"2025030702111559600_r44","doi-asserted-by":"crossref","first-page":"e48117","DOI":"10.1371\/journal.pone.0048117","article-title":"Limited T cell receptor repertoire diversity in tuberculosis patients correlates with clinical severity","volume":"7","author":"Luo","year":"2012","journal-title":"PLoS One"},{"key":"2025030702111559600_r45","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/ni1281","article-title":"Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes","volume":"7","author":"Frahm","year":"2006","journal-title":"Nat. Immunol."},{"key":"2025030702111559600_r46","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.4049\/jimmunol.1001606","article-title":"Responses against a subdominant CD8+ T cell epitope protect against immunopathology caused by a dominant epitope","volume":"185","author":"Ruckwardt","year":"2010","journal-title":"J. Immunol."},{"key":"2025030702111559600_r47","doi-asserted-by":"crossref","first-page":"4829","DOI":"10.1074\/jbc.M110.191437","article-title":"T Cell receptor clonotype influences epitope hierarchy in the CD8+ T cell response to respiratory syncytial virus infection","volume":"286","author":"Billam","year":"2011","journal-title":"J. Biol. Chem."},{"key":"2025030702111559600_r48","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nri2260","article-title":"The molecular basis for public T-cell responses?","volume":"8","author":"Venturi","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"2025030702111559600_r49","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/nri1977","article-title":"Structural determinants of T-cell receptor bias in immunity","volume":"6","author":"Turner","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"2025030702111559600_r50","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/cr.2012.1","article-title":"Determinants of public T cell responses","volume":"22","author":"Li","year":"2012","journal-title":"Cell Res."},{"key":"2025030702111559600_r51","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1126\/science.8105536","article-title":"HLA-DPB1 glutamate 69: a genetic marker of beryllium disease","volume":"262","author":"Richeldi","year":"1993","journal-title":"Science"},{"key":"2025030702111559600_r52","doi-asserted-by":"crossref","first-page":"6910","DOI":"10.4049\/jimmunol.171.12.6910","article-title":"Influence of MHC class II in susceptibility to beryllium sensitization and chronic beryllium disease","volume":"171","author":"Maier","year":"2003","journal-title":"J. Immunol."},{"key":"2025030702111559600_r53","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1136\/oem.2010.055046","article-title":"HLA class II DPB1 and DRB1 polymorphisms associated with genetic susceptibility to beryllium toxicity","volume":"68","author":"Rosenman","year":"2011","journal-title":"Occup. Environ. Med."},{"key":"2025030702111559600_r54","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/1465-9921-6-94","article-title":"Identification of HLA-DRPhe\u03b247 as the susceptibility marker of hypersensitivity to beryllium in individuals lacking the berylliosis-associated supratypic marker HLA-DPGlu\u03b269","volume":"6","author":"Amicosante","year":"2005","journal-title":"Respir. Res."},{"key":"2025030702111559600_r55","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1164\/ajrccm.165.6.2104002","article-title":"Human leukocyte antigen class II amino acid epitopes: susceptibility and progression markers for beryllium hypersensitivity","volume":"165","author":"Rossman","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2025030702111559600_r56","doi-asserted-by":"crossref","first-page":"4014","DOI":"10.4049\/jimmunol.1200798","article-title":"Chronic beryllium disease, HLA-DPB1, and the DP peptide binding groove","volume":"189","author":"Silveira","year":"2012","journal-title":"J. Immunol."},{"key":"2025030702111559600_r57","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.4049\/jimmunol.163.3.1647","article-title":"Differential susceptibilities to chronic beryllium disease contributed by different Glu69 HLA-DPB1 and -DPA1 alleles","volume":"163","author":"Wang","year":"1999","journal-title":"J. Immunol."},{"key":"2025030702111559600_r58","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1164\/rccm.201002-0254OC","article-title":"Risk of chronic beryllium disease by HLA-DPB1 E69 genotype and beryllium exposure in nuclear workers","volume":"183","author":"Van Dyke","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2025030702111559600_r59","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/(SICI)1097-0274(199710)32:4<337::AID-AJIM3>3.0.CO;2-R","article-title":"Interaction of genetic and exposure factors in the prevalence of berylliosis","volume":"32","author":"Richeldi","year":"1997","journal-title":"Am. J. Ind. Med."},{"key":"2025030702111559600_r60","doi-asserted-by":"crossref","first-page":"12717","DOI":"10.1073\/pnas.220430797","article-title":"Beryllium presentation to CD4+ T cells underlies disease-susceptibility HLA-DP alleles in chronic beryllium disease","volume":"97","author":"Fontenot","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030702111559600_r61","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.4049\/jimmunol.166.5.3549","article-title":"HLA-DP allele-specific T cell responses to beryllium account for DP-associated susceptibility to chronic beryllium disease","volume":"166","author":"Lombardi","year":"2001","journal-title":"J. Immunol."},{"issue":"1","key":"2025030702111559600_r62","first-page":"e462","article-title":"Role of high-affinity HLA-DP specific CLIP-derived peptides in beryllium binding to the HLA-DPGlu69 berylliosis-associated molecules and presentation to beryllium-sensitized T cells","volume":"128","author":"Amicosante","year":"2009","journal-title":"Immunology"},{"key":"2025030702111559600_r63","doi-asserted-by":"crossref","first-page":"7425","DOI":"10.1073\/pnas.1001772107","article-title":"Crystal structure of HLA-DP2 and implications for chronic beryllium disease","volume":"107","author":"Dai","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030702111559600_r64","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1084\/jem.20122426","article-title":"Identification of beryllium-dependent peptides recognized by CD4+ T cells in chronic beryllium disease","volume":"210","author":"Falta","year":"2013","journal-title":"J. Exp. Med."},{"key":"2025030702111559600_r65","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1007\/s00251-004-0735-5","article-title":"Characterization of natural peptide ligands from HLA-DP2: new insights into HLA-DP peptide-binding motifs","volume":"56","author":"D\u00edaz","year":"2005","journal-title":"Immunogenetics"},{"key":"2025030702111559600_r66","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s13238-012-2108-4","article-title":"Immune plexins and semaphorins: old proteins, new immune functions","volume":"4","author":"Roney","year":"2013","journal-title":"Protein Cell"},{"key":"2025030702111559600_r67","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.cell.2014.04.048","article-title":"Structural basis of chronic beryllium disease: linking allergic hypersensitivity and autoimmunity","volume":"158","author":"Clayton","year":"2014","journal-title":"Cell"},{"key":"2025030702111559600_r68","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1399-0039.1998.tb02946.x","article-title":"Comprehensive HLA-DP typing using polymerase chain reaction with sequence-specific primers and 95 sequence-specific primer mixes","volume":"51","author":"Gilchrist","year":"1998","journal-title":"Tissue Antigens"},{"key":"2025030702111559600_r69","doi-asserted-by":"crossref","first-page":"8525","DOI":"10.1073\/pnas.131213698","article-title":"BeF(3)(-) acts as a phosphate analog in proteins phosphorylated on aspartate: structure of a BeF(3)(-) complex with phosphoserine phosphatase","volume":"98","author":"Cho","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030702111559600_r70","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1159\/000236703","article-title":"T cell recognition of haptens, a molecular view","volume":"104","author":"Martin","year":"1994","journal-title":"Int. Arch. Allergy Immunol."},{"key":"2025030702111559600_r71","doi-asserted-by":"crossref","first-page":"18517","DOI":"10.1073\/pnas.1215928109","article-title":"T-cell receptor (TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy","volume":"109","author":"Yin","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030702111559600_r72","first-page":"973","article-title":"Animal models of beryllium-induced lung disease","volume":"104","author":"Finch","year":"1996","journal-title":"Environ. Health Perspect."},{"key":"2025030702111559600_r73","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1080\/15476910902977399","article-title":"Genetic determinants of sensitivity to beryllium in mice","volume":"6","author":"Tarantino-Hutchison","year":"2009","journal-title":"J. Immunotoxicol."},{"key":"2025030702111559600_r74","doi-asserted-by":"crossref","first-page":"8553","DOI":"10.1073\/pnas.1408048111","article-title":"Regulatory T cells modulate granulomatous inflammation in an HLA-DP2 transgenic murine model of beryllium-induced disease","volume":"111","author":"Mack","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030702111559600_r75","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1034\/j.1398-9995.2000.00107.x","article-title":"Immunologic mechanisms in hypersensitivity reactions to metal ions: an overview","volume":"55","author":"B\u00fcdinger","year":"2000","journal-title":"Allergy"},{"key":"2025030702111559600_r76","doi-asserted-by":"crossref","first-page":"3308","DOI":"10.1002\/eji.1830251216","article-title":"Characterization of processing requirements and metal cross-reactivities in T cell clones from patients with allergic contact dermatitis to nickel","volume":"25","author":"Moulon","year":"1995","journal-title":"Eur. J. Immunol."},{"key":"2025030702111559600_r77","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/1523-1747.ep12469732","article-title":"HLA-DR, -DQ and -DP alleles in nickel, chromium, and\/or cobalt-sensitive individuals: genomic analysis based on restriction fragment length polymorphisms","volume":"100","author":"Emtestam","year":"1993","journal-title":"J. Invest. Dermatol."},{"key":"2025030702111559600_r78","doi-asserted-by":"crossref","first-page":"3929","DOI":"10.4049\/jimmunol.135.6.3929","article-title":"Isolation and characterization of Ni-specific T cell clones from patients with Ni-contact dermatitis","volume":"135","author":"Sinigaglia","year":"1985","journal-title":"J. Immunol."},{"key":"2025030702111559600_r79","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1002\/j.1460-2075.1991.tb07648.x","article-title":"Selective interaction of Ni with an MHC-bound peptide","volume":"10","author":"Romagnoli","year":"1991","journal-title":"EMBO J."},{"key":"2025030702111559600_r80","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1084\/jem.20021762","article-title":"Components of the ligand for a Ni++ reactive human T cell clone","volume":"197","author":"Lu","year":"2003","journal-title":"J. Exp. Med."},{"key":"2025030702111559600_r81","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.coi.2012.10.002","article-title":"Human leukocyte antigen-associated drug hypersensitivity","volume":"25","author":"Illing","year":"2013","journal-title":"Curr. Opin. Immunol."},{"key":"2025030702111559600_r82","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/nature11147","article-title":"Immune self-reactivity triggered by drug-modified HLA-peptide repertoire","volume":"486","author":"Illing","year":"2012","journal-title":"Nature"},{"key":"2025030702111559600_r83","doi-asserted-by":"crossref","first-page":"9959","DOI":"10.1073\/pnas.1207934109","article-title":"Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire","volume":"109","author":"Ostrov","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030702111559600_r84","doi-asserted-by":"crossref","first-page":"3874","DOI":"10.4049\/jimmunol.177.6.3874","article-title":"Recombinant HLA-DP2 binds beryllium and tolerizes beryllium-specific pathogenic CD4+ T cells","volume":"177","author":"Fontenot","year":"2006","journal-title":"J. Immunol."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/196\/1\/22\/62253547\/1502011.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/196\/1\/22\/62253547\/1502011.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T02:13:44Z","timestamp":1741313624000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/196\/1\/22\/7973586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,1]]},"references-count":84,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1502011","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2016,1]]},"published":{"date-parts":[[2016,1,1]]}}}