{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T13:52:11Z","timestamp":1774533131150,"version":"3.50.1"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>\u03b3\u03b4 T cells respond to molecules upregulated following infection or cellular stress using both TCR and non-TCR molecules. The importance of innate signals versus TCR ligation varies greatly. Both innate-like IL-17\u2013producing \u03b3\u03b4 T (\u03b3\u03b4T-17) and IFN-\u03b3\u2013producing \u03b3\u03b4 T (\u03b3\u03b4T-IFN\u03b3) subsets tune the sensitivity of their TCR following thymic development, allowing robust responses to inflammatory cytokines in the periphery. The remaining conventional \u03b3\u03b4 T cells retain high TCR responsiveness. We determined homeostatic mechanisms that govern these various subsets in the peripheral lymphoid tissues. We found that, although innate-like \u03b3\u03b4T-17 and \u03b3\u03b4T-IFN\u03b3 cells share elements of thymic development, they diverge when it comes to homeostasis. Both exhibit acute sensitivity to cytokines compared with conventional \u03b3\u03b4 T cells, but they do not monopolize the same cytokine. \u03b3\u03b4T-17 cells rely exclusively on IL-7 for turnover and survival, aligning them with NKT17 cells; IL-7 ligation triggers proliferation, as well as promotes survival, upregulating Bcl-2 and Bcl-xL. \u03b3\u03b4T-IFN\u03b3 cells instead depend heavily on IL-15. They display traits analogous to memory CD8+ T cells and upregulate Bcl-xL and Mcl-1 upon cytokine stimulation. The conventional \u03b3\u03b4 T cells display low sensitivity to cytokine-alone stimulation and favor IL-7 for their turnover, characteristics reminiscent of naive \u03b1\u03b2 T cells, suggesting that they may also require tonic TCR signaling for population maintenance. These survival constraints suggest that \u03b3\u03b4 T cell subsets do not directly compete with each other for cytokines, but instead fall into resource niches with other functionally similar lymphocytes.<\/jats:p>","DOI":"10.4049\/jimmunol.1502082","type":"journal-article","created":{"date-parts":[[2015,12,17]],"date-time":"2015-12-17T01:29:32Z","timestamp":1450315772000},"page":"645-654","source":"Crossref","is-referenced-by-count":39,"title":["Differential Responsiveness of Innate-like IL-17\u2013 and IFN-\u03b3\u2013Producing \u03b3\u03b4 T Cells to Homeostatic Cytokines"],"prefix":"10.1093","volume":"196","author":[{"given":"Theresa M","family":"Corpuz","sequence":"first","affiliation":[{"name":"Immunology Division, Garvan Institute of Medical Research , Darlinghurst, New South Wales 2010 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Stolp","sequence":"additional","affiliation":[{"name":"Immunology Division, Garvan Institute of Medical Research , Darlinghurst, New South Wales 2010 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee-Ok","family":"Kim","sequence":"additional","affiliation":[{"name":"Academy of Immunology and Microbiology, Institute for Basic Science , Pohang 790-784 ,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela V","family":"Pinget","sequence":"additional","affiliation":[{"name":"Immunology Division, Garvan Institute of Medical Research , Darlinghurst, New South Wales 2010 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel H D","family":"Gray","sequence":"additional","affiliation":[{"name":"Molecular Genetics of Cancer Division and Immunology Division, The Walter and Eliza Hall Institute of Medical Research , Parkville, Victoria 3052 ,","place":["Australia"]},{"name":"Department of Medical Biology, University of Melbourne , Parkville, Victoria 3010 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae-Ho","family":"Cho","sequence":"additional","affiliation":[{"name":"Academy of Immunology and Microbiology, Institute for Basic Science , Pohang 790-784 ,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Sprent","sequence":"additional","affiliation":[{"name":"Immunology Division, Garvan Institute of Medical Research , Darlinghurst, New South Wales 2010 ,","place":["Australia"]},{"name":"St. Vincent\u2019s Clinical School, University of New South Wales , Sydney, New South Wales 2010 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kylie E","family":"Webster","sequence":"additional","affiliation":[{"name":"Immunology Division, Garvan Institute of Medical Research , Darlinghurst, New South Wales 2010 ,","place":["Australia"]},{"name":"St. Vincent\u2019s Clinical School, University of New South Wales , Sydney, New South Wales 2010 ,","place":["Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,1,15]]},"reference":[{"key":"2025030702114868600_r1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/nri2781","article-title":"Gammadelta T cell effector functions: a blend of innate programming and acquired plasticity","volume":"10","author":"Bonneville","year":"2010","journal-title":"Nat. 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