{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:10:16Z","timestamp":1790143816767,"version":"4.0.1"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Guillain\u2013Barr\u00e9 syndrome (GBS) is an immune-mediated peripheral neuropathy. The goal of this research was the identification of biomarkers associated with recovery from GBS. In this study, we compared the transcriptome of PBMCs from a GBS patient and her healthy twin to discover possible correlates of disease progression and recovery. The study was then extended using GBS and spinal cord injury unrelated patients with similar medications and healthy individuals. The early growth response gene-2 (EGR2) was upregulated in GBS patients during disease recovery. The results provided evidence for the implication of EGR2 in GBS and suggested a role for EGR2 in the regulation of IL-17, IL-22, IL-28A, and TNF-\u03b2 cytokines in GBS patients. These results identified biomarkers associated with GBS recovery and suggested that EGR2 overexpression has a pivotal role in the downregulation of cytokines implicated in the pathophysiology of this acute neuropathy.<\/jats:p>","DOI":"10.4049\/jimmunol.1502100","type":"journal-article","created":{"date-parts":[[2015,12,31]],"date-time":"2015-12-31T03:13:24Z","timestamp":1451531604000},"page":"1102-1107","source":"Crossref","is-referenced-by-count":18,"title":["Expression of Early Growth Response Gene-2 and Regulated Cytokines Correlates with Recovery from Guillain\u2013Barr\u00e9 Syndrome"],"prefix":"10.1093","volume":"196","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2704-9782","authenticated-orcid":false,"given":"Ernesto","family":"Doncel-P\u00e9rez","sequence":"first","affiliation":[{"name":"Hospital Nacional de Parapl\u00e9jicos, Servicio de Salud de Castilla La Mancha , 45071 Toledo ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"Mateos-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"SaBio, Instituto de Investigaci\u00f3n en Recursos Cineg\u00e9ticos IREC-CSIC-UCLM-JCCM , 13005 Ciudad Real ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7878-0786","authenticated-orcid":false,"given":"Eduardo","family":"Pareja","sequence":"additional","affiliation":[{"name":"Oh no sequences! Research Group, Era7 Bioinformatics , 18001 Granada ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel","family":"Garc\u00eda-Forcada","sequence":"additional","affiliation":[{"name":"Hospital Nacional de Parapl\u00e9jicos, Servicio de Salud de Castilla La Mancha , 45071 Toledo ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Villar","sequence":"additional","affiliation":[{"name":"SaBio, Instituto de Investigaci\u00f3n en Recursos Cineg\u00e9ticos IREC-CSIC-UCLM-JCCM , 13005 Ciudad Real ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7032-8720","authenticated-orcid":false,"given":"Raquel","family":"Tobes","sequence":"additional","affiliation":[{"name":"Oh no sequences! Research Group, Era7 Bioinformatics , 18001 Granada ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Romero Ganuza","sequence":"additional","affiliation":[{"name":"Hospital Nacional de Parapl\u00e9jicos, Servicio de Salud de Castilla La Mancha , 45071 Toledo ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5606-2767","authenticated-orcid":false,"given":"Virginia","family":"Vila del Sol","sequence":"additional","affiliation":[{"name":"Hospital Nacional de Parapl\u00e9jicos, Servicio de Salud de Castilla La Mancha , 45071 Toledo ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6331-9786","authenticated-orcid":false,"given":"Ricardo","family":"Ramos","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Parque Cient\u00edfico de Madrid , 28049 Madrid ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5936-4018","authenticated-orcid":false,"given":"Isabel G","family":"Fern\u00e1ndez de Mera","sequence":"additional","affiliation":[{"name":"SaBio, Instituto de Investigaci\u00f3n en Recursos Cineg\u00e9ticos IREC-CSIC-UCLM-JCCM , 13005 Ciudad Real ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"de la Fuente","sequence":"additional","affiliation":[{"name":"SaBio, Instituto de Investigaci\u00f3n en Recursos Cineg\u00e9ticos IREC-CSIC-UCLM-JCCM , 13005 Ciudad Real ,","place":["Spain"]},{"name":"Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University , Stillwater, OK 74078"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,2,1]]},"reference":[{"key":"2025030702123201500_r1","first-page":"1462","article-title":"Sur un syndrome de radiculon\u00e9vrite avec hyperalbuminose due liquide c\u00e9phalo-rachidien sans r\u00e9action cellulaire: remarques sur les caract\u00e9res cliniques et graphiques des r\u00e9flexes tendineux","volume":"40","author":"Guillain","year":"1916","journal-title":"Bull Soc M\u00e9d H\u00f4p Paris"},{"key":"2025030702123201500_r2","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nrneurol.2014.121","article-title":"Guillain\u2011Barr\u00e9 syndrome: pathogenesis, diagnosis, treatment and prognosis","volume":"10","author":"van den Berg","year":"2014","journal-title":"Nat. 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