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CD83\u2212\/\u2212 mice have a strong reduction of CD4+ T cells, which makes it difficult to analyze a functional role of CD83 on B cells during GC responses. Therefore, in the present study we generated a B cell\u2013specific CD83 conditional knockout (CD83 B-cKO) model. CD83 B-cKO B cells show defective upregulation of MHC class II and CD86 expression and impaired proliferation after different stimuli. Analyses of GC responses after immunization with various Ags revealed a characteristic shift in dark zone and light zone B cell numbers, with an increase of B cells in the dark zone of CD83 B-cKO mice. This effect was not accompanied by alterations in the level of IgG immune responses or by major differences in affinity maturation. However, an enhanced IgE response was observed in CD83 B-cKO mice. Additionally, we observed a strong competitive disadvantage of CD83-cKO B cells in GC responses in mixed bone marrow chimeras. Furthermore, infection of mice with Borrelia burgdorferi revealed a defect in bacterial clearance of CD83 B-cKO mice with a shift toward a Th2 response, indicated by a strong increase in IgE titers. Taken together, our results show that CD83 is important for B cell activation and modulates GC composition and IgE Ab responses in vivo.<\/jats:p>","DOI":"10.4049\/jimmunol.1502163","type":"journal-article","created":{"date-parts":[[2016,3,17]],"date-time":"2016-03-17T02:29:05Z","timestamp":1458181745000},"page":"3581-3594","source":"Crossref","is-referenced-by-count":102,"title":["CD83 Modulates B Cell Activation and Germinal Center Responses"],"prefix":"10.1093","volume":"196","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5030-1720","authenticated-orcid":false,"given":"Lena","family":"Krzyzak","sequence":"first","affiliation":[{"name":"Department of Immune Modulation, University Hospital Erlangen , 91052 Erlangen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Seitz","sequence":"additional","affiliation":[{"name":"Department of Immune Modulation, University Hospital Erlangen , 91052 Erlangen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Urbat","sequence":"additional","affiliation":[{"name":"Division of Genetics, Department of Biology, University of Erlangen , 91058 Erlangen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Hutzler","sequence":"additional","affiliation":[{"name":"Division of Genetics, Department of Biology, University of Erlangen , 91058 Erlangen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6676-0497","authenticated-orcid":false,"given":"Christian","family":"Ostalecki","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Hospital Erlangen , 91052 Erlangen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Gl\u00e4sner","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology and Hygiene, University of Regensburg , 93053 Regensburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3154-0638","authenticated-orcid":false,"given":"Andreas","family":"Hiergeist","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology and Hygiene, University of Regensburg , 93053 Regensburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Gessner","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology and Hygiene, University of Regensburg , 93053 Regensburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas H","family":"Winkler","sequence":"additional","affiliation":[{"name":"Division of Genetics, Nikolaus Fiebiger Center for Molecular Medicine, University of Erlangen , 91058 Erlangen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7187-6729","authenticated-orcid":false,"given":"Alexander","family":"Steinkasserer","sequence":"additional","affiliation":[{"name":"Department of Immune Modulation, University Hospital Erlangen , 91052 Erlangen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Nitschke","sequence":"additional","affiliation":[{"name":"Division of Genetics, Department of Biology, University of Erlangen , 91058 Erlangen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,5,1]]},"reference":[{"key":"2025030702163284000_r1","doi-asserted-by":"crossref","first-page":"735","DOI":"10.4049\/jimmunol.149.2.735","article-title":"A novel cell-surface molecule expressed by human interdigitating reticulum cells, Langerhans cells, and activated lymphocytes is a new member of the Ig superfamily","volume":"149","author":"Zhou","year":"1992","journal-title":"J. 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