{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:46:20Z","timestamp":1791294380110,"version":"4.1.0"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Type I IFN (IFN-\u03b1\/\u03b2) is thought to enhance growth of the foodborne intracellular pathogen Listeria monocytogenes by promoting mechanisms that dampen innate immunity to infection. However, the type I IFN response has been studied primarily using methods that bypass the stomach and, therefore, fail to replicate the natural course of L. monocytogenes infection. In this study, we compared i.v. and foodborne transmission of L. monocytogenes in mice lacking the common type I IFN receptor (IFNAR1\u2212\/\u2212). Contrary to what was observed using i.v. infection, IFNAR1\u2212\/\u2212 and wild-type mice had similar bacterial burdens in the liver and spleen following foodborne infection. Splenocytes from wild-type mice infected i.v. produced significantly more IFN-\u03b2 than did those infected by the foodborne route. Consequently, the immunosuppressive effects of type I IFN signaling, which included T cell death, increased IL-10 secretion, and repression of neutrophil recruitment to the spleen, were all observed following i.v. but not foodborne transmission of L. monocytogenes. Type I IFN was also previously shown to cause a loss of responsiveness to IFN-\u03b3 through downregulation of the IFN-\u03b3 receptor \u03b1-chain on macrophages and dendritic cells. However, we detected a decrease in surface expression of IFN-\u03b3 receptor \u03b1-chain even in the absence of IFN-\u03b1\/\u03b2 signaling, suggesting that in vivo, this infection-induced phenotype is not type I IFN\u2013dependent. These results highlight the importance of using the natural route of infection for studies of host\u2013pathogen interactions and suggest that the detrimental effects of IFN-\u03b1\/\u03b2 signaling on the innate immune response to L. monocytogenes may be an artifact of the i.v. infection model.<\/jats:p>","DOI":"10.4049\/jimmunol.1502192","type":"journal-article","created":{"date-parts":[[2016,2,19]],"date-time":"2016-02-19T22:13:18Z","timestamp":1455919998000},"page":"3109-3116","source":"Crossref","is-referenced-by-count":35,"title":["Type I IFN Does Not Promote Susceptibility to Foodborne\n                    <i>Listeria monocytogenes<\/i>"],"prefix":"10.1093","volume":"196","author":[{"given":"Michelle G","family":"Pitts","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky , Lexington, KY 40536"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Myers-Morales","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky , Lexington, KY 40536"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E F","family":"D\u2019Orazio","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky , Lexington, KY 40536"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,4,1]]},"reference":[{"key":"2025030702151377200_r1","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/nri1604","article-title":"Mechanisms of type-I- and type-II-interferon-mediated signalling","volume":"5","author":"Platanias","year":"2005","journal-title":"Nat. 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