{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T04:42:54Z","timestamp":1792816974733,"version":"4.5.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>How the metabolic demand of parasitism affects immune-mediated resistance is poorly understood. Immunity against parasitic helminths requires M2 cells and IL-13, secreted by CD4+ Th2 and group 2 innate lymphoid cells (ILC2), but whether certain metabolic enzymes control disease outcome has not been addressed. This study demonstrates that AMP-activated protein kinase (AMPK), a key driver of cellular energy, regulates type 2 immunity and restricts lung injury following hookworm infection. Mice with a selective deficiency in the AMPK catalytic \u03b11 subunit in alveolar macrophages and conventional dendritic cells produced less IL-13 and CCL17 and had impaired expansion of ILC2 in damaged lung tissue compared with wild-type controls. Defective type 2 responses were marked by increased intestinal worm burdens, exacerbated lung injury, and increased production of IL-12\/23p40, which, when neutralized, restored IL-13 production and improved lung recovery. Taken together, these data indicate that defective AMPK activity in myeloid cells negatively impacts type 2 responses through increased IL-12\/23p40 production. These data support an emerging concept that myeloid cells and ILC2 can coordinately regulate tissue damage at mucosal sites through mechanisms dependent on metabolic enzyme function.<\/jats:p>","DOI":"10.4049\/jimmunol.1502218","type":"journal-article","created":{"date-parts":[[2016,4,21]],"date-time":"2016-04-21T05:41:12Z","timestamp":1461217272000},"page":"4632-4640","source":"Crossref","is-referenced-by-count":27,"title":["Myeloid-Restricted AMPK\u03b11 Promotes Host Immunity and Protects against IL-12\/23p40\u2013Dependent Lung Injury during Hookworm Infection"],"prefix":"10.1093","volume":"196","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9687-8333","authenticated-orcid":false,"given":"Wildaliz","family":"Nieves","sequence":"first","affiliation":[{"name":"Division of Experimental Medicine, Department of Medicine, University of California San Francisco , San Francisco, CA 94110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Yin","family":"Hung","sequence":"additional","affiliation":[{"name":"Division of Experimental Medicine, Department of Medicine, University of California San Francisco , San Francisco, CA 94110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor K","family":"Oniskey","sequence":"additional","affiliation":[{"name":"Division of Experimental Medicine, Department of Medicine, University of California San Francisco , San Francisco, CA 94110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Boon","sequence":"additional","affiliation":[{"name":"EPIRUS Biopharmaceuticals Netherlands BV , 3584 CM Utrecht ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Foretz","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherch\u00e9 M\u00e9dicale U1016, Institut Cochin , 75014 Paris ,","place":["France"]},{"name":"CNRS, UMR 8104 , 75014 Paris ,","place":["France"]},{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9 , 75006 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0121-0224","authenticated-orcid":false,"given":"Benoit","family":"Viollet","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherch\u00e9 M\u00e9dicale U1016, Institut Cochin , 75014 Paris ,","place":["France"]},{"name":"CNRS, UMR 8104 , 75014 Paris ,","place":["France"]},{"name":"Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9 , 75006 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2449-5365","authenticated-orcid":false,"given":"De\u2019Broski R","family":"Herbert","sequence":"additional","affiliation":[{"name":"Division of Experimental Medicine, Department of Medicine, University of California San Francisco , San Francisco, CA 94110"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,6,1]]},"reference":[{"key":"2025030702173357300_r1","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nature09932","article-title":"Structure of mammalian AMPK and its regulation by ADP","volume":"472","author":"Xiao","year":"2011","journal-title":"Nature"},{"key":"2025030702173357300_r2","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1161\/01.RES.0000256090.42690.05","article-title":"AMP-activated protein kinase in metabolic control and insulin signaling","volume":"100","author":"Towler","year":"2007","journal-title":"Circ. 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