{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:54:02Z","timestamp":1791500042334,"version":"4.3.4"},"reference-count":75,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The mucosal immune system represents the first line of defense against Brucella infection in nature. We used genetically deficient mice to identify the lymphocytes and signaling pathways implicated in the control of primary and secondary intranasal infection with B. melitensis. Our analysis of primary infection demonstrated that the effectors implicated differ at the early and late stages and are dependent on the organ. TCR-\u03b4, TAP1, and IL-17RA deficiency specifically affects early control of Brucella in the lungs, whereas MHC class II (MHCII) and IFN-\u03b3R deficiency impairs late control in the lungs, spleen, and liver. Interestingly, IL-12p35\u2212\/\u2212 mice display enhanced Brucella growth in the spleen but not in the lungs or liver. Secondary intranasal infections are efficiently contained in the lung. In contrast to an i.p. infectious model, in which IL-12p35, MHCII, and B cells are strictly required for the control of secondary infection, we observed that only TCR-\u03b2 deficiency or simultaneous neutralization of IL-12p35\u2013 and IL-17A\u2013dependent pathways impairs the memory protective response against a secondary intranasal infection. Protection is not affected by TCR-\u03b4, MHCII, TAP1, B cell, IL-17RA, or IL-12p35 deficiency, suggesting that CD4+ and CD8+ \u03b1\/\u03b2+ T cells are sufficient to mount a protective immune response and that an IL-17A\u2013mediated response can compensate for the partial deficiency of an IFN-\u03b3\u2013mediated response to control a Brucella challenge. These findings demonstrate that the nature of the protective memory response depends closely on the route of infection and highlights the role of IFN-\u03b3\u2013and IL-17RA\u2013mediated responses in the control of mucosal infection by Brucella.<\/jats:p>","DOI":"10.4049\/jimmunol.1502265","type":"journal-article","created":{"date-parts":[[2016,4,2]],"date-time":"2016-04-02T03:10:49Z","timestamp":1459566649000},"page":"3780-3793","source":"Crossref","is-referenced-by-count":37,"title":["Identification of Immune Effectors Essential to the Control of Primary and Secondary Intranasal Infection with <i>Brucella melitensis<\/i> in Mice"],"prefix":"10.1093","volume":"196","author":[{"given":"Delphine","family":"Hanot Mambres","sequence":"first","affiliation":[{"name":"Microorganisms Biology Research Unit (URBM), Laboratory of Immunology and Microbiology, Namur Research Institute for Life Sciences, University of Namur , 5000 Namur ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Machelart","sequence":"additional","affiliation":[{"name":"Microorganisms Biology Research Unit (URBM), Laboratory of Immunology and Microbiology, Namur Research Institute for Life Sciences, University of Namur , 5000 Namur ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4226-1845","authenticated-orcid":false,"given":"Georges","family":"Potemberg","sequence":"additional","affiliation":[{"name":"Microorganisms Biology Research Unit (URBM), Laboratory of Immunology and Microbiology, Namur Research Institute for Life Sciences, University of Namur , 5000 Namur ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"De Trez","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Interactions, Flanders Interuniversity Institute for Biotechnology, Free University of Brussels (VUB) , 1050 Brussels ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Ryffel","sequence":"additional","affiliation":[{"name":"Immunologie et Neurog\u00e9n\u00e9tique Exp\u00e9rimentales et Mol\u00e9culaires \u2013 UMR7355 CNRS \u2013 Universit\u00e9 d'Orl\u00e9ans , 45071 Orleans ,","place":["France"]},{"name":"Institute of Infectious Disease and Molecular Medicine, University of Cape Town , Capetown 7925 ,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Jacques","family":"Letesson","sequence":"additional","affiliation":[{"name":"Microorganisms Biology Research Unit (URBM), Laboratory of Immunology and Microbiology, Namur Research Institute for Life Sciences, University of Namur , 5000 Namur ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Muraille","sequence":"additional","affiliation":[{"name":"Microorganisms Biology Research Unit (URBM), Laboratory of Immunology and Microbiology, Namur Research Institute for Life Sciences, University of Namur , 5000 Namur ,","place":["Belgium"]},{"name":"Laboratoire de Parasitologie, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Libre de Bruxelles , 1070 Bruxelles ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,5,1]]},"reference":[{"key":"2025030702160746800_r1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1051\/vetres:2005003","article-title":"From the discovery of the Malta fever\u2019s agent to the discovery of a marine mammal reservoir, brucellosis has continuously been a re-emerging zoonosis","volume":"36","author":"Godfroid","year":"2005","journal-title":"Vet. Res."},{"key":"2025030702160746800_r2","doi-asserted-by":"crossref","first-page":"147","DOI":"10.2217\/fmb.12.140","article-title":"Brucella evasion of adaptive immunity","volume":"8","author":"Martirosyan","year":"2013","journal-title":"Future Microbiol."},{"key":"2025030702160746800_r3","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/00005792-199607000-00003","article-title":"Complications associated with Brucella melitensis infection: a study of 530 cases","volume":"75","author":"Colmenero","year":"1996","journal-title":"Medicine (Baltimore)"},{"key":"2025030702160746800_r4","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S1473-3099(06)70382-6","article-title":"The new global map of human brucellosis","volume":"6","author":"Pappas","year":"2006","journal-title":"Lancet Infect. Dis."},{"key":"2025030702160746800_r5","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.vetmic.2009.06.021","article-title":"Brucellosis: a re-emerging zoonosis","volume":"140","author":"Seleem","year":"2010","journal-title":"Vet. Microbiol."},{"key":"2025030702160746800_r6","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1007\/s00018-006-6311-4","article-title":"Brucella as a biological weapon","volume":"63","author":"Pappas","year":"2006","journal-title":"Cell. Mol. Life Sci."},{"key":"2025030702160746800_r7","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1134\/S106235901007006X","article-title":"Reservoirs of Brucella infection in nature","volume":"37","author":"Zheludkov","year":"2010","journal-title":"Biol. Bull."},{"key":"2025030702160746800_r8","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/1746-6148-8-80","article-title":"A serological and bacteriological survey of brucellosis in wild boar (Sus scrofa) in Belgium","volume":"8","author":"Gr\u00e9goire","year":"2012","journal-title":"BMC Vet. Res."},{"key":"2025030702160746800_r9","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0163-4453(98)93342-4","article-title":"Multivariate model for predicting relapse in human brucellosis","volume":"36","author":"Solera","year":"1998","journal-title":"J. Infect."},{"key":"2025030702160746800_r10","doi-asserted-by":"crossref","first-page":"D40","DOI":"10.1016\/j.vaccine.2009.08.058","article-title":"Brucellosis: the case for live, attenuated vaccines","volume":"27","author":"Ficht","year":"2009","journal-title":"Vaccine"},{"key":"2025030702160746800_r11","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1586\/erv.11.110","article-title":"Confronting the barriers to develop novel vaccines against brucellosis","volume":"10","author":"Oliveira","year":"2011","journal-title":"Expert Rev. Vaccines"},{"key":"2025030702160746800_r12","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.4049\/jimmunol.180.2.1080","article-title":"Central role of MyD88-dependent dendritic cell maturation and proinflammatory cytokine production to control Brucella abortus infection","volume":"180","author":"Macedo","year":"2008","journal-title":"J. Immunol."},{"key":"2025030702160746800_r13","doi-asserted-by":"crossref","first-page":"5137","DOI":"10.1128\/IAI.73.8.5137-5143.2005","article-title":"MyD88, but not toll-like receptors 4 and 2, is required for efficient clearance of Brucella abortus","volume":"73","author":"Weiss","year":"2005","journal-title":"Infect. Immun."},{"key":"2025030702160746800_r14","doi-asserted-by":"crossref","first-page":"5182","DOI":"10.4049\/jimmunol.178.8.5182","article-title":"MyD88-dependent activation of B220-CD11b+LY-6C+ dendritic cells during Brucella melitensis infection","volume":"178","author":"Copin","year":"2007","journal-title":"J. Immunol."},{"key":"2025030702160746800_r15","doi-asserted-by":"crossref","first-page":"4899","DOI":"10.1128\/iai.61.11.4899-4901.1993","article-title":"Endogenous gamma interferon mediates resistance to Brucella abortus infection","volume":"61","author":"Zhan","year":"1993","journal-title":"Infect. Immun."},{"key":"2025030702160746800_r16","doi-asserted-by":"crossref","first-page":"4271","DOI":"10.1128\/IAI.00761-12","article-title":"Crucial role of gamma interferon-producing CD4+ Th1 cells but dispensable function of CD8+ T cell, B cell, Th2, and Th17 responses in the control of Brucella melitensis infection in mice","volume":"80","author":"Vitry","year":"2012","journal-title":"Infect. Immun."},{"key":"2025030702160746800_r17","doi-asserted-by":"crossref","first-page":"3740","DOI":"10.4049\/jimmunol.1302561","article-title":"Humoral immunity and CD4+ Th1 cells are both necessary for a fully protective immune response upon secondary infection with Brucella melitensis","volume":"192","author":"Vitry","year":"2014","journal-title":"J. Immunol."},{"key":"2025030702160746800_r18","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1749-6632.1980.tb18912.x","article-title":"Airborne spread of brucellosis","volume":"353","author":"Kaufmann","year":"1980","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"2025030702160746800_r19","first-page":"E15","article-title":"Bichat guidelines for the clinical management of brucellosis and bioterrorism-related brucellosis","volume":"9","author":"Bossi","year":"2004","journal-title":"Euro Surveill."},{"key":"2025030702160746800_r20","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/srep00495","article-title":"The pathophysiology of inhalational brucellosis in BALB\/c mice","volume":"2","author":"Henning","year":"2012","journal-title":"Sci. Rep."},{"key":"2025030702160746800_r21","doi-asserted-by":"crossref","first-page":"644","DOI":"10.2460\/ajvr.2004.65.644","article-title":"Pathologic changes associated with brucellosis experimentally induced by aerosol exposure in rhesus macaques (Macaca mulatta)","volume":"65","author":"Mense","year":"2004","journal-title":"Am. J. Vet. Res."},{"key":"2025030702160746800_r22","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3389\/fcimb.2012.00115","article-title":"Toll-like receptors are critical for clearance of Brucella and play different roles in development of adaptive immunity following aerosol challenge in mice","volume":"2","author":"Pei","year":"2012","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"2025030702160746800_r23","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1126\/science.8456301","article-title":"Immune response in mice that lack the interferon-gamma receptor","volume":"259","author":"Huang","year":"1993","journal-title":"Science"},{"key":"2025030702160746800_r24","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1084\/jem.183.2.515","article-title":"Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice","volume":"183","author":"Carrera","year":"1996","journal-title":"J. Exp. Med."},{"key":"2025030702160746800_r25","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S1074-7613(00)80413-6","article-title":"IL-12-deficient mice are defective in IFN \u03b3 production and type 1 cytokine responses","volume":"4","author":"Magram","year":"1996","journal-title":"Immunity"},{"key":"2025030702160746800_r26","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S1074-7613(02)00391-6","article-title":"Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses","volume":"17","author":"Nakae","year":"2002","journal-title":"Immunity"},{"key":"2025030702160746800_r27","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.4049\/jimmunol.172.5.2827","article-title":"Compromised humoral and delayed-type hypersensitivity responses in IL-23-deficient mice","volume":"172","author":"Ghilardi","year":"2004","journal-title":"J. Immunol."},{"key":"2025030702160746800_r28","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/S0092-8674(05)80068-6","article-title":"TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells","volume":"71","author":"Van Kaer","year":"1992","journal-title":"Cell"},{"key":"2025030702160746800_r29","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/0092-8674(91)90448-8","article-title":"Mice lacking MHC class II molecules","volume":"66","author":"Cosgrove","year":"1991","journal-title":"Cell"},{"key":"2025030702160746800_r30","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/0092-8674(92)90030-G","article-title":"RAG-1-deficient mice have no mature B and T lymphocytes","volume":"68","author":"Mombaerts","year":"1992","journal-title":"Cell"},{"key":"2025030702160746800_r31","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0092-8674(00)00078-7","article-title":"Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme","volume":"102","author":"Muramatsu","year":"2000","journal-title":"Cell"},{"key":"2025030702160746800_r32","doi-asserted-by":"crossref","first-page":"8093","DOI":"10.1073\/pnas.94.15.8093","article-title":"Characterization of tumor necrosis factor-deficient mice","volume":"94","author":"Marino","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030702160746800_r33","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1002\/j.1460-2075.1994.tb06368.x","article-title":"Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion","volume":"13","author":"Poli","year":"1994","journal-title":"EMBO J."},{"key":"2025030702160746800_r34","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1038\/nbt1037","article-title":"Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein","volume":"22","author":"Shaner","year":"2004","journal-title":"Nat. Biotechnol."},{"key":"2025030702160746800_r35","doi-asserted-by":"crossref","first-page":"e1002575","DOI":"10.1371\/journal.ppat.1002575","article-title":"In situ microscopy analysis reveals local innate immune response developed around Brucella infected cells in resistant and susceptible mice","volume":"8","author":"Copin","year":"2012","journal-title":"PLoS Pathog."},{"key":"2025030702160746800_r36","doi-asserted-by":"crossref","first-page":"5314","DOI":"10.1128\/IAI.68.9.5314-5320.2000","article-title":"Impaired control of Brucella melitensis infection in Rag1-deficient mice","volume":"68","author":"Izadjoo","year":"2000","journal-title":"Infect. Immun."},{"key":"2025030702160746800_r37","doi-asserted-by":"crossref","first-page":"398","DOI":"10.2460\/ajvr.2001.62.398","article-title":"Bacteriologic and histologic features in mice after intranasal inoculation of Brucella melitensis","volume":"62","author":"Mense","year":"2001","journal-title":"Am. J. Vet. Res."},{"key":"2025030702160746800_r38","doi-asserted-by":"crossref","first-page":"3927","DOI":"10.1128\/IAI.01779-14","article-title":"Brucella melitensis invades murine erythrocytes during infection","volume":"82","author":"Vitry","year":"2014","journal-title":"Infect. Immun."},{"key":"2025030702160746800_r39","doi-asserted-by":"crossref","first-page":"3458","DOI":"10.1002\/eji.201040497","article-title":"Contrasting roles of macrophages and dendritic cells in controlling initial pulmonary Brucella infection","volume":"40","author":"Archambaud","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"2025030702160746800_r40","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1084\/jem.186.10.1757","article-title":"Defects in macrophage recruitment and host defense in mice lacking the CCR2 chemokine receptor","volume":"186","author":"Kurihara","year":"1997","journal-title":"J. Exp. Med."},{"key":"2025030702160746800_r41","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1046\/j.1365-2567.2001.01258.x","article-title":"Interferon-gamma is crucial for surviving a Brucella abortus infection in both resistant C57BL\/6 and susceptible BALB\/c mice","volume":"103","author":"Murphy","year":"2001","journal-title":"Immunology"},{"key":"2025030702160746800_r42","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.4049\/jimmunol.168.5.2433","article-title":"Susceptibility of IFN regulatory factor-1 and IFN consensus sequence binding protein-deficient mice to brucellosis","volume":"168","author":"Ko","year":"2002","journal-title":"J. Immunol."},{"key":"2025030702160746800_r43","doi-asserted-by":"crossref","first-page":"589494","DOI":"10.1155\/2012\/589494","article-title":"Host susceptibility to Brucella abortus infection is more pronounced in IFN-\u03b3 knockout than IL-12\/\u03b22-microglobulin double-deficient mice","volume":"2012","author":"Brand\u00e3o","year":"2012","journal-title":"Clin. Dev. Immunol."},{"key":"2025030702160746800_r44","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1196\/annals.1425.027","article-title":"Chronic diseases in developing countries: health and economic burdens","volume":"1136","author":"Nugent","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"2025030702160746800_r45","doi-asserted-by":"crossref","first-page":"6883","DOI":"10.4049\/jimmunol.0901466","article-title":"What role does the route of immunization play in the generation of protective immunity against mucosal pathogens?","volume":"183","author":"Belyakov","year":"2009","journal-title":"J. Immunol."},{"key":"2025030702160746800_r46","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1600-065X.2010.00982.x","article-title":"An evolutionary strategy for a stealthy intracellular Brucella pathogen","volume":"240","author":"Martirosyan","year":"2011","journal-title":"Immunol. Rev."},{"key":"2025030702160746800_r47","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1111\/cmi.12160","article-title":"Serving the new masters - dendritic cells as hosts for stealth intracellular bacteria","volume":"15","author":"Fabrik","year":"2013","journal-title":"Cell. Microbiol."},{"key":"2025030702160746800_r48","doi-asserted-by":"crossref","first-page":"4923","DOI":"10.1128\/IAI.00451-07","article-title":"Aerosol infection of BALB\/c mice with Brucella melitensis and Brucella abortus and protective efficacy against aerosol challenge","volume":"75","author":"Kahl-McDonagh","year":"2007","journal-title":"Infect. Immun."},{"key":"2025030702160746800_r49","doi-asserted-by":"crossref","first-page":"3324","DOI":"10.1128\/IAI.70.7.3324-3329.2002","article-title":"Protection of mice against brucellosis by intranasal immunization with Brucella melitensis lipopolysaccharide as a noncovalent complex with Neisseria meningitidis group B outer membrane protein","volume":"70","author":"Bhattacharjee","year":"2002","journal-title":"Infect. Immun."},{"key":"2025030702160746800_r50","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/j.micinf.2004.08.009","article-title":"IL-1 receptor-associated kinase 1 mediates protection against Staphylococcus aureus infection","volume":"6","author":"Verdrengh","year":"2004","journal-title":"Microbes Infect."},{"key":"2025030702160746800_r51","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1128\/IAI.01980-06","article-title":"Resistance to Pseudomonas aeruginosa chronic lung infection requires cystic fibrosis transmembrane conductance regulator-modulated interleukin-1 (IL-1) release and signaling through the IL-1 receptor","volume":"75","author":"Reiniger","year":"2007","journal-title":"Infect. Immun."},{"key":"2025030702160746800_r52","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1128\/iai.63.6.2262-2268.1995","article-title":"Interleukin-6-deficient mice are highly susceptible to Listeria monocytogenes infection: correlation with inefficient neutrophilia","volume":"63","author":"Dalrymple","year":"1995","journal-title":"Infect. Immun."},{"key":"2025030702160746800_r53","doi-asserted-by":"crossref","first-page":"3231","DOI":"10.1128\/iai.64.8.3231-3235.1996","article-title":"Interleukin-6 is required for a protective immune response to systemic Escherichia coli infection","volume":"64","author":"Dalrymple","year":"1996","journal-title":"Infect. Immun."},{"key":"2025030702160746800_r54","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1046\/j.1365-3024.1998.00152.x","article-title":"A protective role for IL-6 during early infection with Toxoplasma gondii","volume":"20","author":"Jebbari","year":"1998","journal-title":"Parasite Immunol."},{"key":"2025030702160746800_r55","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1038\/srep01809","article-title":"Prominent role for T cell-derived tumour necrosis factor for sustained control of Mycobacterium tuberculosis infection","volume":"3","author":"Allie","year":"2013","journal-title":"Sci. Rep."},{"key":"2025030702160746800_r56","doi-asserted-by":"crossref","first-page":"3972","DOI":"10.4049\/jimmunol.177.6.3972","article-title":"TNF is important for pathogen control and limits brain damage in murine cerebral listeriosis","volume":"177","author":"Virna","year":"2006","journal-title":"J. Immunol."},{"key":"2025030702160746800_r57","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.cyto.2008.08.015","article-title":"TNF receptor 1 and 2 contribute in different ways to resistance to Legionella pneumophila-induced mortality in mice","volume":"44","author":"Fujita","year":"2008","journal-title":"Cytokine"},{"key":"2025030702160746800_r58","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1128\/IAI.01237-13","article-title":"Key role of Toll-like receptor 2 in the inflammatory response and major histocompatibility complex class ii downregulation in Brucella abortus-infected alveolar macrophages","volume":"82","author":"Ferrero","year":"2014","journal-title":"Infect. Immun."},{"key":"2025030702160746800_r59","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1038\/cr.2011.59","article-title":"A MyD88-dependent IFN\u03b3R-CCR2 signaling circuit is required for mobilization of monocytes and host defense against systemic bacterial challenge","volume":"21","author":"Pietras","year":"2011","journal-title":"Cell Res."},{"key":"2025030702160746800_r60","doi-asserted-by":"crossref","first-page":"e1000494","DOI":"10.1371\/journal.ppat.1000494","article-title":"iNOS-producing inflammatory dendritic cells constitute the major infected cell type during the chronic Leishmania major infection phase of C57BL\/6 resistant mice","volume":"5","author":"De Trez","year":"2009","journal-title":"PLoS Pathog."},{"key":"2025030702160746800_r61","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.immuni.2011.02.012","article-title":"Functional specialization of interleukin-17 family members","volume":"34","author":"Iwakura","year":"2011","journal-title":"Immunity"},{"key":"2025030702160746800_r62","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1365-2567.2008.03017.x","article-title":"Interleukin-17 in host defence against bacterial, mycobacterial and fungal pathogens","volume":"126","author":"Curtis","year":"2009","journal-title":"Immunology"},{"key":"2025030702160746800_r63","doi-asserted-by":"crossref","first-page":"267971","DOI":"10.1155\/2013\/267971","article-title":"IL-17A and Th17 cells in lung inflammation: an update on the role of Th17 cell differentiation and IL-17R signaling in host defense against infection","volume":"2013","author":"Tsai","year":"2013","journal-title":"Clin. Dev. Immunol."},{"key":"2025030702160746800_r64","doi-asserted-by":"crossref","first-page":"4478","DOI":"10.4049\/jimmunol.1203172","article-title":"Cutting edge: the pathogenicity of IFN-\u03b3-producing Th17 cells is independent of T-bet","volume":"190","author":"Duhen","year":"2013","journal-title":"J. Immunol."},{"key":"2025030702160746800_r65","doi-asserted-by":"crossref","first-page":"e21978","DOI":"10.1371\/journal.pone.0021978","article-title":"Murine and bovine \u03b3\u03b4 T cells enhance innate immunity against Brucella abortus infections","volume":"6","author":"Skyberg","year":"2011","journal-title":"PLoS One"},{"key":"2025030702160746800_r66","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/1471-2172-13-65","article-title":"Depletion of neutrophils in a protective model of pulmonary cryptococcosis results in increased IL-17A production by \u03b3\u03b4 T cells","volume":"13","author":"Wozniak","year":"2012","journal-title":"BMC Immunol."},{"key":"2025030702160746800_r67","doi-asserted-by":"crossref","first-page":"4503","DOI":"10.1128\/IAI.05799-11","article-title":"Protective role of naturally occurring interleukin-17A-producing \u03b3\u03b4 T cells in the lung at the early stage of systemic candidiasis in mice","volume":"79","author":"Dejima","year":"2011","journal-title":"Infect. Immun."},{"key":"2025030702160746800_r68","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1471-2172-13-38","article-title":"Role of gamma-delta T cells in host response against Staphylococcus aureus\u2013induced pneumonia","volume":"13","author":"Cheng","year":"2012","journal-title":"BMC Immunol."},{"key":"2025030702160746800_r69","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1189\/jlb.1211626","article-title":"IFN-\u03b3-deficient mice develop IL-1-dependent cutaneous and musculoskeletal inflammation during experimental brucellosis","volume":"92","author":"Skyberg","year":"2012","journal-title":"J. Leukoc. Biol."},{"key":"2025030702160746800_r70","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.4049\/jimmunol.1001893","article-title":"Infection-induced myelopoiesis during intracellular bacterial infection is critically dependent upon IFN-\u03b3 signaling","volume":"186","author":"MacNamara","year":"2011","journal-title":"J. Immunol."},{"key":"2025030702160746800_r71","doi-asserted-by":"crossref","first-page":"e1003167","DOI":"10.1371\/journal.ppat.1003167","article-title":"Neutrophils exert a suppressive effect on Th1 responses to intracellular pathogen Brucella abortus","volume":"9","author":"Barquero-Calvo","year":"2013","journal-title":"PLoS Pathog."},{"key":"2025030702160746800_r72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2013.00001","article-title":"NET balancing: a problem in inflammatory lung diseases","volume":"4","author":"Cheng","year":"2013","journal-title":"Front. Immunol."},{"key":"2025030702160746800_r73","doi-asserted-by":"crossref","first-page":"e34925","DOI":"10.1371\/journal.pone.0034925","article-title":"Active evasion of CTL mediated killing and low quality responding CD8+ T cells contribute to persistence of brucellosis","volume":"7","author":"Durward","year":"2012","journal-title":"PLoS One"},{"key":"2025030702160746800_r74","doi-asserted-by":"crossref","first-page":"4759","DOI":"10.1128\/IAI.01184-15","article-title":"CD8+ T cell exhaustion, suppressed gamma interferon production, and delayed memory response induced by chronic Brucella melitensis infection","volume":"83","author":"Durward-Diioia","year":"2015","journal-title":"Infect. Immun."},{"key":"2025030702160746800_r75","doi-asserted-by":"crossref","first-page":"4165","DOI":"10.1128\/IAI.05080-11","article-title":"Protective live oral brucellosis vaccines stimulate Th1 and th17 cell responses","volume":"79","author":"Clapp","year":"2011","journal-title":"Infect. Immun."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/196\/9\/3780\/62253408\/1502265.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/196\/9\/3780\/62253408\/1502265.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T02:35:49Z","timestamp":1741314949000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/196\/9\/3780\/7974383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,1]]},"references-count":75,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,5,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1502265","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2016,5]]},"published":{"date-parts":[[2016,5,1]]}}}