{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:02:45Z","timestamp":1780444965656,"version":"3.54.1"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Menin, a tumor suppressor protein, is encoded by the MEN1 gene in humans. Certain germinal mutations of MEN1 induce an autosomal-dominant syndrome that is characterized by concurrent parathyroid adenomas and several other tumor types. Although menin is also expressed in hematopoietic lineages, its role in CD8+ T cells remains unclear. We generated Meninflox\/flox CD4-Cre (Menin-KO) mice by crossing Meninflox\/flox mice with CD4-Cre transgenic (Tg) mice to determine the role of menin in CD8+ T cells. Wild-type (WT) and Menin-KO mice were infected with Listeria monocytogenes expressing OVA to analyze the immune response of Ag-specific CD8+ T cells. Menin deficiency resulted in an impaired primary immune response by CD8+ T cells. On day 7, there were fewer Menin-KO OVA-specific CD8+ T cells compared with WT cells. Next, we adoptively transferred WT and Menin-KO OT-1 Tg CD8+ T cells into congenic recipient mice and infected them with L. monocytogenes expressing OVA to determine the CD8+ T cell\u2013intrinsic effect. Menin-KO OT-1 Tg CD8+ T cells were outcompeted by the WT cells upon infection. Increased expression of Blimp-1 and T-bet, cell cycle inhibitors, and proapoptotic genes was observed in the Menin-KO OT-1 Tg CD8+ T cells upon infection. These data suggest that menin inhibits differentiation into terminal effectors and positively controls proliferation and survival of Ag-specific CD8+ T cells that are activated upon infection. Collectively, our study uncovered an important role for menin in the immune response of CD8+ T cells to infection.<\/jats:p>","DOI":"10.4049\/jimmunol.1502295","type":"journal-article","created":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T02:34:00Z","timestamp":1476930840000},"page":"4079-4089","source":"Crossref","is-referenced-by-count":13,"title":["Menin Plays a Critical Role in the Regulation of the Antigen-Specific CD8+ T Cell Response upon <i>Listeria<\/i> Infection"],"prefix":"10.1093","volume":"197","author":[{"given":"Takeshi","family":"Yamada","sequence":"first","affiliation":[{"name":"Department of Infection and Host Defenses, Graduate School of Medicine, Ehime University , Shitsukawa, Toon, Ehime 791-0295,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0151-3556","authenticated-orcid":false,"given":"Makoto","family":"Kanoh","sequence":"additional","affiliation":[{"name":"Department of Infection and Host Defenses, Graduate School of Medicine, Ehime University , Shitsukawa, Toon, Ehime 791-0295,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogo","family":"Nabe","sequence":"additional","affiliation":[{"name":"Department of Hematology, Clinical Immunology, and Infectious diseases, Graduate School of Medicine, Ehime University , Shitsukawa, Toon, Ehime 791-0295,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1435-0779","authenticated-orcid":false,"given":"Toshiaki","family":"Yasuoka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medicine, Ehime University , Shitsukawa, Toon, Ehime 791-0295,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junpei","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Hematology, Clinical Immunology, and Infectious diseases, Graduate School of Medicine, Ehime University , Shitsukawa, Toon, Ehime 791-0295,","place":["Japan"]},{"name":"Department of Immunology, Graduate School of Medicine, Ehime University , Shitsukawa, Toon, Ehime 791-0295,","place":["Japan"]},{"name":"Translational Research Center, Ehime University Hospital , Shitsukawa, Toon, Ehime 791-0295,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Infection and Host Defenses, Graduate School of Medicine, Ehime University , Shitsukawa, Toon, Ehime 791-0295,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Kuwahara","sequence":"additional","affiliation":[{"name":"Department of Immunology, Graduate School of Medicine, Ehime University , Shitsukawa, Toon, Ehime 791-0295,","place":["Japan"]},{"name":"Translational Research Center, Ehime University Hospital , Shitsukawa, Toon, Ehime 791-0295,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saho","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Department of Immunology, Graduate School of Medicine, Ehime University , Shitsukawa, Toon, Ehime 791-0295,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Infection and Host Defenses, Graduate School of Medicine, Ehime University , Shitsukawa, Toon, Ehime 791-0295,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Sakisuka","sequence":"additional","affiliation":[{"name":"Department of Infection and Host Defenses, Graduate School of Medicine, Ehime University , Shitsukawa, Toon, Ehime 791-0295,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1538-433X","authenticated-orcid":false,"given":"Masaki","family":"Yasukawa","sequence":"additional","affiliation":[{"name":"Department of Hematology, Clinical Immunology, and Infectious diseases, Graduate School of Medicine, Ehime University , Shitsukawa, Toon, Ehime 791-0295,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakatsu","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Immunology, Graduate School of Medicine, Ehime University , Shitsukawa, Toon, Ehime 791-0295,","place":["Japan"]},{"name":"Translational Research Center, Ehime University Hospital , Shitsukawa, Toon, Ehime 791-0295,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,11,15]]},"reference":[{"key":"2025030618354276900_r1","doi-asserted-by":"crossref","first-page":"h988","DOI":"10.1136\/bmj.h988","article-title":"Cancer vaccines","volume":"350","author":"Butterfield","year":"2015","journal-title":"BMJ"},{"key":"2025030618354276900_r2","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1177\/2051013614525375","article-title":"MHC class I antigen presentation and implications for developing a new generation of therapeutic vaccines","volume":"2","author":"Comber","year":"2014","journal-title":"Ther. Adv. Vaccines"},{"key":"2025030618354276900_r3","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/j.0105-2896.2010.00899.x","article-title":"Plasticity in programming of effector and memory CD8 T-cell formation","volume":"235","author":"Arens","year":"2010","journal-title":"Immunol. Rev."},{"key":"2025030618354276900_r4","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/nri3307","article-title":"Transcriptional control of effector and memory CD8+ T cell differentiation","volume":"12","author":"Kaech","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"2025030618354276900_r5","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nri2274","article-title":"T-cell quality in memory and protection: implications for vaccine design","volume":"8","author":"Seder","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"2025030618354276900_r6","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1038\/ni.3031","article-title":"Molecular regulation of effector and memory T cell differentiation","volume":"15","author":"Chang","year":"2014","journal-title":"Nat. Immunol."},{"key":"2025030618354276900_r7","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/icb.2015.9","article-title":"G0S2 modulates homeostatic proliferation of na\u00efve CD8\u207a T cells and inhibits oxidative phosphorylation in mitochondria","volume":"93","author":"Lee","year":"2015","journal-title":"Immunol. Cell Biol."},{"key":"2025030618354276900_r8","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/ni.2536","article-title":"Transcriptional insights into the CD8+ T cell response to infection and memory T cell formation","volume":"14","author":"Best","year":"2013","journal-title":"Nat. Immunol."},{"key":"2025030618354276900_r9","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/imr.12205","article-title":"The interface between transcriptional and epigenetic control of effector and memory CD8\u207a T-cell differentiation","volume":"261","author":"Gray","year":"2014","journal-title":"Immunol. Rev."},{"key":"2025030618354276900_r10","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.4049\/jimmunol.1200750","article-title":"Id2 influences differentiation of killer cell lectin-like receptor G1(hi) short-lived CD8+ effector T cells","volume":"190","author":"Knell","year":"2013","journal-title":"J. Immunol."},{"key":"2025030618354276900_r11","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.coi.2013.05.010","article-title":"Transcriptional regulation of effector and memory CD8+ T cell fates","volume":"25","author":"Thaventhiran","year":"2013","journal-title":"Curr. Opin. Immunol."},{"key":"2025030618354276900_r12","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1038\/ni.1730","article-title":"Transcription factor ELF4 controls the proliferation and homing of CD8+ T cells via the Kr\u00fcppel-like factors KLF4 and KLF2","volume":"10","author":"Yamada","year":"2009","journal-title":"Nat. Immunol."},{"key":"2025030618354276900_r13","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1038\/ni1009","article-title":"Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells","volume":"4","author":"Kaech","year":"2003","journal-title":"Nat. Immunol."},{"key":"2025030618354276900_r14","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.immuni.2007.07.010","article-title":"Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor","volume":"27","author":"Joshi","year":"2007","journal-title":"Immunity"},{"key":"2025030618354276900_r15","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/ni802","article-title":"Role for Bcl-6 in the generation and maintenance of memory CD8+ T cells","volume":"3","author":"Ichii","year":"2002","journal-title":"Nat. Immunol."},{"key":"2025030618354276900_r16","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1196\/annals.1294.020","article-title":"Molecular pathology of the MEN1 gene","volume":"1014","author":"Agarwal","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"2025030618354276900_r17","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1093\/ndt\/13.9.2176","article-title":"Menin and MEN 1 gene: a model of tumour suppressor system","volume":"13","author":"Hory","year":"1998","journal-title":"Nephrol. Dial. Transplant."},{"key":"2025030618354276900_r18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0304-3835(02)00509-8","article-title":"Menin interacting proteins as clues toward the understanding of multiple endocrine neoplasia type 1","volume":"189","author":"Poisson","year":"2003","journal-title":"Cancer Lett."},{"key":"2025030618354276900_r19","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1159\/000371819","article-title":"MEN1, MEN4, and carney complex: pathology and molecular genetics","volume":"103","author":"Schernthaner-Reiter","year":"2016","journal-title":"Neuroendocrinology"},{"key":"2025030618354276900_r20","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1038\/ncomms4555","article-title":"The Menin-Bach2 axis is critical for regulating CD4 T-cell senescence and cytokine homeostasis","volume":"5","author":"Kuwahara","year":"2014","journal-title":"Nat. Commun."},{"key":"2025030618354276900_r21","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1093\/intimm\/10.5.577","article-title":"Requirement for p56(lck) tyrosine kinase activation in Th subset differentiation","volume":"10","author":"Yamashita","year":"1998","journal-title":"Int. Immunol."},{"key":"2025030618354276900_r22","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.immuni.2011.03.020","article-title":"Protective capacity of memory CD8+ T cells is dictated by antigen exposure history and nature of the infection","volume":"34","author":"Nolz","year":"2011","journal-title":"Immunity"},{"key":"2025030618354276900_r23","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s00281-015-0477-5","article-title":"Listeria monocytogenes: a model pathogen to study antigen-specific memory CD8 T cell responses","volume":"37","author":"Khan","year":"2015","journal-title":"Semin. Immunopathol."},{"key":"2025030618354276900_r24","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1158\/0008-5472.CAN-10-3221","article-title":"The tumor suppressor protein menin inhibits AKT activation by regulating its cellular localization","volume":"71","author":"Wang","year":"2011","journal-title":"Cancer Res."},{"key":"2025030618354276900_r25","doi-asserted-by":"crossref","first-page":"805","DOI":"10.2174\/156652408786733702","article-title":"Menin, histone h3 methyltransferases, and regulation of cell proliferation: current knowledge and perspective","volume":"8","author":"Wu","year":"2008","journal-title":"Curr. Mol. Med."},{"key":"2025030618354276900_r26","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/nrm1987","article-title":"Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all","volume":"7","author":"Gil","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2025030618354276900_r27","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/35073039","article-title":"Mechanisms of transcriptional memory","volume":"2","author":"Francis","year":"2001","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2025030618354276900_r28","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/nature10806","article-title":"The same pocket in menin binds both MLL and JUND but has opposite effects on transcription","volume":"482","author":"Huang","year":"2012","journal-title":"Nature"},{"key":"2025030618354276900_r29","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1371\/journal.pgen.0020051","article-title":"Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis","volume":"2","author":"Scacheri","year":"2006","journal-title":"PLoS Genet."},{"key":"2025030618354276900_r30","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.archger.2015.08.007","article-title":"Aging-associated subpopulations of human CD8+ T-lymphocytes identified by their CD28 and CD57 phenotypes","volume":"61","author":"Onyema","year":"2015","journal-title":"Arch. Gerontol. Geriatr."},{"key":"2025030618354276900_r31","doi-asserted-by":"crossref","first-page":"4110","DOI":"10.1038\/sj.onc.1209437","article-title":"The tumor suppressor p16Ink4a regulates T lymphocyte survival","volume":"25","author":"Bianchi","year":"2006","journal-title":"Oncogene"},{"key":"2025030618354276900_r32","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.smim.2009.02.001","article-title":"Critical role of the Polycomb and Trithorax complexes in the maintenance of CD4 T cell memory","volume":"21","author":"Nakayama","year":"2009","journal-title":"Semin. Immunol."},{"key":"2025030618354276900_r33","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1084\/jem.20072000","article-title":"Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene","volume":"205","author":"Yamashita","year":"2008","journal-title":"J. Exp. Med."},{"key":"2025030618354276900_r34","doi-asserted-by":"crossref","first-page":"8161","DOI":"10.1128\/JVI.00889-12","article-title":"Progressive loss of memory T cell potential and commitment to exhaustion during chronic viral infection","volume":"86","author":"Angelosanto","year":"2012","journal-title":"J. Virol."},{"key":"2025030618354276900_r35","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/ni.2035","article-title":"T cell exhaustion","volume":"12","author":"Wherry","year":"2011","journal-title":"Nat. Immunol."},{"key":"2025030618354276900_r36","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1038\/ni1098","article-title":"CD8+ T cell contraction is controlled by early inflammation","volume":"5","author":"Badovinac","year":"2004","journal-title":"Nat. Immunol."},{"key":"2025030618354276900_r37","doi-asserted-by":"crossref","first-page":"4967","DOI":"10.4049\/jimmunol.1102335","article-title":"Pathogen-induced inflammatory environment controls effector and memory CD8+ T cell differentiation","volume":"187","author":"Obar","year":"2011","journal-title":"J. Immunol."},{"key":"2025030618354276900_r38","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.immuni.2009.05.014","article-title":"Transcriptional repressor Blimp-1 promotes CD8(+) T cell terminal differentiation and represses the acquisition of central memory T cell properties","volume":"31","author":"Rutishauser","year":"2009","journal-title":"Immunity"},{"key":"2025030618354276900_r39","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1084\/jem.20070841","article-title":"Requirement for T-bet in the aberrant differentiation of unhelped memory CD8+ T cells","volume":"204","author":"Intlekofer","year":"2007","journal-title":"J. Exp. Med."},{"key":"2025030618354276900_r40","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.immuni.2009.06.021","article-title":"Blimp-1 transcription factor is required for the differentiation of effector CD8(+) T cells and memory responses","volume":"31","author":"Kallies","year":"2009","journal-title":"Immunity"},{"key":"2025030618354276900_r41","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/ni1320","article-title":"Transcriptional repressor Blimp-1 regulates T cell homeostasis and function","volume":"7","author":"Martins","year":"2006","journal-title":"Nat. Immunol."},{"key":"2025030618354276900_r42","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0092-8674(00)80967-8","article-title":"Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription","volume":"96","author":"Agarwal","year":"1999","journal-title":"Cell"},{"key":"2025030618354276900_r43","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1507\/endocrj.51.333","article-title":"JunD-menin interaction regulates c-Jun-mediated AP-1 transactivation","volume":"51","author":"Ikeo","year":"2004","journal-title":"Endocr. J."},{"key":"2025030618354276900_r44","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/emm.2005.57","article-title":"Menin represses JunD transcriptional activity in protein kinase C theta-mediated Nur77 expression","volume":"37","author":"Kim","year":"2005","journal-title":"Exp. Mol. Med."},{"key":"2025030618354276900_r45","doi-asserted-by":"crossref","first-page":"4988","DOI":"10.4049\/jimmunol.1002042","article-title":"Cutting edge: the transcription factor eomesodermin enables CD8+ T cells to compete for the memory cell niche","volume":"185","author":"Banerjee","year":"2010","journal-title":"J. Immunol."},{"key":"2025030618354276900_r46","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.immuni.2011.09.017","article-title":"An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells","volume":"35","author":"Cui","year":"2011","journal-title":"Immunity"},{"key":"2025030618354276900_r47","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/ni.1679","article-title":"Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection","volume":"10","author":"Blackburn","year":"2009","journal-title":"Nat. Immunol."},{"key":"2025030618354276900_r48","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.immuni.2009.06.019","article-title":"A role for the transcriptional repressor Blimp-1 in CD8(+) T cell exhaustion during chronic viral infection","volume":"31","author":"Shin","year":"2009","journal-title":"Immunity"},{"key":"2025030618354276900_r49","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.immuni.2009.08.005","article-title":"Blimp hovers over T cell immunity","volume":"31","author":"Welsh","year":"2009","journal-title":"Immunity"},{"key":"2025030618354276900_r50","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1189\/jlb.0912438","article-title":"Increased T-bet is associated with senescence of influenza virus-specific CD8 T cells in aged humans","volume":"93","author":"Dolfi","year":"2013","journal-title":"J. Leukoc. Biol."},{"key":"2025030618354276900_r51","doi-asserted-by":"crossref","first-page":"3563","DOI":"10.18632\/oncotarget.2969","article-title":"p19ARF is a critical mediator of both cellular senescence and an innate immune response associated with MYC inactivation in mouse model of acute leukemia","volume":"6","author":"Yetil","year":"2015","journal-title":"Oncotarget"},{"key":"2025030618354276900_r52","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.1038\/ncomms3830","article-title":"A genome-wide regulatory network identifies key transcription factors for memory CD8\u207a T-cell development","volume":"4","author":"Hu","year":"2013","journal-title":"Nat. Commun."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/197\/10\/4079\/61569519\/1502295.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/197\/10\/4079\/61569519\/1502295.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T19:15:02Z","timestamp":1741288502000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/197\/10\/4079\/7973530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":52,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,11,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1502295","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2016,11]]},"published":{"date-parts":[[2016,11]]}}}