{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:18:14Z","timestamp":1790720294920,"version":"4.1.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>It is well known that sensitization against fungi is closely associated with severity of asthma. Dectin-1 (gene symbol Clec7a), a C-type lectin receptor, recognizes the fungal cell wall component \u03b2-glucan, as well as some component(s) in house dust mite (HDM) extract. However, the roles of Dectin-1 in HDM-induced allergic airway inflammation remain unclear. In this study, we used Dectin-1\u2013deficient (Clec7a\u2212\/\u2212) mice to examine whether Dectin-1 is involved in HDM-induced allergic airway inflammation. We found that HDM-induced eosinophil and neutrophil recruitment into the airways was significantly attenuated in Clec7a\u2212\/\u2212 mice compared with that in wild-type mice. In addition, HDM-induced IL-5, IL-13, and IL-17 production from mediastinum lymph node cells was reduced in HDM-sensitized Clec7a\u2212\/\u2212 mice. Dectin-1 was expressed on CD11b+ dendritic cells (DCs), an essential DC subset for the development of allergic inflammation, but not on CD103+ DCs, plasmacytoid DCs, or lung epithelial cells. Transcriptome analysis revealed that the expression of chemokine\/chemokine receptors, including CCR7, which is indispensable for DC migration to draining lymph nodes, was decreased in Clec7a\u2212\/\u2212 DCs. In accordance with these results, the number of HDM-labeled CD11b+ DCs in mediastinum lymph nodes was significantly reduced in Clec7a\u2212\/\u2212 mice compared with wild-type mice. Taken together, these results suggest that Dectin-1 expressed on CD11b+ DCs senses some molecule(s) in HDM extract and plays a critical role in the induction of HDM-induced allergic airway inflammation by inducing the expression of chemokine\/chemokine receptors in DCs.<\/jats:p>","DOI":"10.4049\/jimmunol.1502393","type":"journal-article","created":{"date-parts":[[2016,11,17]],"date-time":"2016-11-17T03:50:29Z","timestamp":1479354629000},"page":"61-70","source":"Crossref","is-referenced-by-count":83,"title":["Dectin-1 Plays an Important Role in House Dust Mite\u2013Induced Allergic Airway Inflammation through the Activation of CD11b+ Dendritic Cells"],"prefix":"10.1093","volume":"198","author":[{"given":"Takashi","family":"Ito","sequence":"first","affiliation":[{"name":"Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University , Chiba 260-8670,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Hirose","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University , Chiba 260-8670,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayako","family":"Norimoto","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University , Chiba 260-8670,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Tamachi","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University , Chiba 260-8670,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Yokota","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University , Chiba 260-8670,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiko","family":"Saku","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University , Chiba 260-8670,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Takatori","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University , Chiba 260-8670,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3802-8821","authenticated-orcid":false,"given":"Shinobu","family":"Saijo","sequence":"additional","affiliation":[{"name":"Department of Molecular Immunology, Medical Mycology Research Center, Chiba University , Chiba 260-8670,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichiro","family":"Iwakura","sequence":"additional","affiliation":[{"name":"Research Institute for Biomedical Sciences, Tokyo University of Science , Chiba 278-0022,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University , Chiba 260-8670,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,1,1]]},"reference":[{"key":"2025030614553806000_r1","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.cell.2010.03.004","article-title":"Asthma and allergic inflammation","volume":"140","author":"Locksley","year":"2010","journal-title":"Cell"},{"key":"2025030614553806000_r2","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1016\/S0140-6736(13)61536-6","article-title":"Asthma","volume":"382","author":"Martinez","year":"2013","journal-title":"Lancet"},{"key":"2025030614553806000_r3","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1164\/rccm.200906-0896OC","article-title":"Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program","volume":"181","author":"Moore","year":"2010","journal-title":"Am. 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