{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:52:59Z","timestamp":1790758379268,"version":"4.1.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The microtubule-associated protein lissencephaly 1 (Lis1) is a key regulator of cell division during stem cell renewal and differentiation. In this study, we examined the role of Lis1 in T lymphocyte homeostasis and fate diversification in response to microbial infection. T cell\u2013specific deletion of Lis1 resulted in depletion of the peripheral CD4+ and CD8+ T lymphocyte pool owing to a loss of homeostatic, cytokine-induced proliferation. In contrast, cognate Ag-triggered proliferation was much less affected, enabling Lis1-deficient CD8+ T cells to differentiate into terminal effector cells in response to microbial infection. Strikingly, however, the specification of Lis1-deficient long-lived memory CD8+ T lymphocytes was impaired due, in part, to an apparent failure to differentiate appropriately to IL-15. Taken together, these findings suggest that Lis1 plays an important role in T cell homeostasis and the generation of memory T lymphocytes.<\/jats:p>","DOI":"10.4049\/jimmunol.1502410","type":"journal-article","created":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T03:00:03Z","timestamp":1459393203000},"page":"4237-4245","source":"Crossref","is-referenced-by-count":8,"title":["The Microtubule-Associated Protein Lis1 Regulates T Lymphocyte Homeostasis and Differentiation"],"prefix":"10.1093","volume":"196","author":[{"given":"Soo M","family":"Ngoi","sequence":"first","affiliation":[{"name":"Department of Medicine, University of California San Diego , La Jolla, CA 92093"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine M","family":"Lopez","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Diego , La Jolla, CA 92093"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Diego , La Jolla, CA 92093"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,5,15]]},"reference":[{"key":"2025030702171137400_r1","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/nri2657","article-title":"Naive T cell homeostasis: from awareness of space to a sense of place","volume":"9","author":"Takada","year":"2009","journal-title":"Nat. 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