{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T14:21:40Z","timestamp":1786371700194,"version":"build-2736575974"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Molecules that are necessary for ocular hypersensitivity reactions include the receptors CCR1 and CCR3; CCL7 is a ligand for these receptors. Therefore, we explored the role of CCL7 in mast cell activity and motility in vitro and investigated the requirement for CCL7 in a murine model of IgE-mediated allergic conjunctivitis. For mast cells treated with IgE and Ag, the presence of CCL7 synergistically enhanced degranulation and calcium influx. CCL7 also induced chemotaxis in mast cells. CCL7-deficient bone marrow\u2013derived mast cells showed decreased degranulation following IgE and Ag treatment compared with wild-type bone marrow\u2013derived mast cells, but there was no difference in degranulation when cells were activated via an IgE-independent pathway. In vivo, CCL7 was upregulated in conjunctival tissue during an OVA-induced allergic response. Notably, the early-phase clinical symptoms in the conjunctiva after OVA challenge were significantly higher in OVA-sensitized wild-type mice than in control challenged wild-type mice; the increase was suppressed in CCL7-deficient mice. In the OVA-induced allergic response, the numbers of conjunctival mast cells were lower in CCL7-deficient mice than in wild-type mice. Our results demonstrate that CCL7 is required for maximal OVA-induced ocular anaphylaxis, mast cell recruitment in vivo, and maximal Fc\u03b5RI-mediated mast cell activation in vitro. A better understanding of the role of CCL7 in mediating ocular hypersensitivity reactions will provide insights into mast cell function and novel treatments for allergic ocular diseases.<\/jats:p>","DOI":"10.4049\/jimmunol.1502416","type":"journal-article","created":{"date-parts":[[2016,12,13]],"date-time":"2016-12-13T02:30:42Z","timestamp":1481596242000},"page":"645-656","source":"Crossref","is-referenced-by-count":24,"title":["Role of CCL7 in Type I Hypersensitivity Reactions in Murine Experimental Allergic Conjunctivitis"],"prefix":"10.1093","volume":"198","author":[{"given":"Chuan-Hui","family":"Kuo","sequence":"first","affiliation":[{"name":"Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children\u2019s Hospital, Medical Center , Cincinnati, OH 45229"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea M","family":"Collins","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children\u2019s Hospital, Medical Center , Cincinnati, OH 45229"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0591-443X","authenticated-orcid":false,"given":"Douglas R","family":"Boettner","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children\u2019s Hospital, Medical Center , Cincinnati, OH 45229"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YanFen","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children\u2019s Hospital, Medical Center , Cincinnati, OH 45229"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santa J","family":"Ono","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children\u2019s Hospital, Medical Center , Cincinnati, OH 45229"},{"name":"University of Cincinnati , Cincinnati, OH 45229"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,1,15]]},"reference":[{"key":"2025030614595878800_r1","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3109\/02713683.2012.747617","article-title":"New twists to an old story: novel concepts in the pathogenesis of allergic eye disease","volume":"38","author":"Saban","year":"2013","journal-title":"Curr. 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