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Recent insights on the implication of STAT3, AKT, and Wnt\/\u03b2-catenin in fibrosis have prompted us to investigate, in a mouse model of ROS-induced SSc, the effects of niclosamide, an antihelmintic drug that inhibits both of these signaling pathways. SSc was induced in BALB\/c mice by daily s.c. injections of hypochlorous acid (HOCl). Mice were treated or not every other day, 5 d a week, for 6 wk, by niclosamide. Skin and lung fibrosis as well as immunological features were studied. Mice exposed to HOCl developed a diffuse cutaneous SSc with pulmonary fibrosis and anti-DNA topoisomerase 1 autoantibodies. STAT3, AKT, and Wnt\/\u03b2-catenin pathways were hyperactivated in the skin and the lungs of diseased mice. Niclosamide reversed fibrosis of the skin and the lungs. Beneficial immunological effects were also observed because niclosamide decreased the activation of CD4+ and CD8+ T cells, autoimmune B cell activation, as well as IL-4 and IL-13 production in the skin. The improvement permitted by niclosamide in the mouse model of HOCl-induced SSc as well as the well-documented safety profile of this drug provide a rationale for the evaluation of niclosamide in the management of patients affected by this disease.<\/jats:p>","DOI":"10.4049\/jimmunol.1502482","type":"journal-article","created":{"date-parts":[[2016,9,10]],"date-time":"2016-09-10T01:29:48Z","timestamp":1473470988000},"page":"3018-3028","source":"Crossref","is-referenced-by-count":32,"title":["Niclosamide Prevents Systemic Sclerosis in a Reactive Oxygen Species\u2013Induced Mouse Model"],"prefix":"10.1093","volume":"197","author":[{"given":"Florence","family":"Morin","sequence":"first","affiliation":[{"name":"Institut Cochin, INSERM U1016, CNRS, UMR8104, Universit\u00e9 Paris Descartes, Universit\u00e9 Sorbonne Paris Cit\u00e9 , 75014 Paris,","place":["France"]},{"name":"Laboratoire d\u2019Immunologie Biologique, H\u00f4pital Cochin, Assistance Publique-Hopitaux de Paris , 75679 Paris Cedex 14,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niloufar","family":"Kavian","sequence":"additional","affiliation":[{"name":"Institut Cochin, INSERM U1016, CNRS, UMR8104, Universit\u00e9 Paris Descartes, Universit\u00e9 Sorbonne Paris Cit\u00e9 , 75014 Paris,","place":["France"]},{"name":"Laboratoire d\u2019Immunologie Biologique, H\u00f4pital Cochin, Assistance Publique-Hopitaux de Paris , 75679 Paris Cedex 14,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Nicco","sequence":"additional","affiliation":[{"name":"Institut Cochin, INSERM U1016, CNRS, UMR8104, Universit\u00e9 Paris Descartes, Universit\u00e9 Sorbonne Paris Cit\u00e9 , 75014 Paris,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5697-7484","authenticated-orcid":false,"given":"Olivier","family":"Cerles","sequence":"additional","affiliation":[{"name":"Institut Cochin, INSERM U1016, CNRS, UMR8104, Universit\u00e9 Paris Descartes, Universit\u00e9 Sorbonne Paris Cit\u00e9 , 75014 Paris,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Ch\u00e9reau","sequence":"additional","affiliation":[{"name":"Institut Cochin, INSERM U1016, CNRS, UMR8104, Universit\u00e9 Paris Descartes, Universit\u00e9 Sorbonne Paris Cit\u00e9 , 75014 Paris,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Batteux","sequence":"additional","affiliation":[{"name":"Institut Cochin, INSERM U1016, CNRS, UMR8104, Universit\u00e9 Paris Descartes, Universit\u00e9 Sorbonne Paris Cit\u00e9 , 75014 Paris,","place":["France"]},{"name":"Laboratoire d\u2019Immunologie Biologique, H\u00f4pital Cochin, Assistance Publique-Hopitaux de Paris , 75679 Paris Cedex 14,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,10,15]]},"reference":[{"key":"2025030617554860000_r1","doi-asserted-by":"crossref","first-page":"272","DOI":"10.3389\/fimmu.2015.00272","article-title":"Pathogenesis of systemic sclerosis","volume":"6","author":"Pattanaik","year":"2015","journal-title":"Front. 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