{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T07:52:16Z","timestamp":1780645936973,"version":"3.54.1"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The development of the fetal immune system during pregnancy is a well-orchestrated process with important consequences for fetal and neonatal health, but prenatal factors that affect immune activation are poorly understood. We hypothesized that chronic fetal inflammation may lead to alterations in development of the fetal immune system. To test this hypothesis, we examined neonates with gastroschisis, a congenital abdominal wall defect that leads to exposure of the fetal intestines to amniotic fluid, with resultant intestinal inflammation. We determined that patients with gastroschisis show high systemic levels of inflammatory cytokines and chemokines such as eotaxin, as well as earlier activation of CD4+ and CD8+ effector and memory T cells in the cord blood compared with controls. Additionally, increased numbers of T cells and eosinophils infiltrate the serosa and mucosa of the inflamed intestines. Using a mouse model of gastroschisis, we observed higher numbers of eosinophils and both type 2 and type 3 innate lymphoid cells (ILC2 and ILC3), specifically in the portion of organs exposed to the amniotic fluid. Given the role of IL-5 produced by ILC2 in regulating eosinophil development and survival, we determined that maternal or fetal administration of the anti\u2013IL-5 neutralizing Ab, or a depleting Ab against ILCs, can both effectively reduce intestinal eosinophilia. Thus, a congenital anomaly causing chronic inflammation can alter the composition of circulating and tissue-resident fetal immune cells. Given the high rate of prenatal and neonatal complications in these patients, such changes have clinical significance and might become targets for fetal therapy.<\/jats:p>","DOI":"10.4049\/jimmunol.1502587","type":"journal-article","created":{"date-parts":[[2016,5,14]],"date-time":"2016-05-14T04:25:25Z","timestamp":1463199925000},"page":"4957-4966","source":"Crossref","is-referenced-by-count":20,"title":["Heightened Immune Activation in Fetuses with Gastroschisis May Be Blocked by Targeting IL-5"],"prefix":"10.1093","volume":"196","author":[{"given":"Michela","family":"Frascoli","sequence":"first","affiliation":[{"name":"Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco , San Francisco, CA 94143"},{"name":"Department of Surgery, University of California San Francisco , San Francisco, CA 94143"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cerine","family":"Jeanty","sequence":"additional","affiliation":[{"name":"Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco , San Francisco, CA 94143"},{"name":"Department of Surgery, University of California San Francisco , San Francisco, CA 94143"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5607-6819","authenticated-orcid":false,"given":"Shannon","family":"Fleck","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of California San Francisco , San Francisco, CA 94143"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patriss W","family":"Moradi","sequence":"additional","affiliation":[{"name":"Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco , San Francisco, CA 94143"},{"name":"Department of Surgery, University of California San Francisco , San Francisco, CA 94143"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8324-3694","authenticated-orcid":false,"given":"Sheila","family":"Keating","sequence":"additional","affiliation":[{"name":"Blood Systems Research Institute , San Francisco, CA 94118"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5813-164X","authenticated-orcid":false,"given":"Aras N","family":"Mattis","sequence":"additional","affiliation":[{"name":"Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco , San Francisco, CA 94143"},{"name":"Department of Pathology, University of California San Francisco , San Francisco, CA 94143"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7313-3574","authenticated-orcid":false,"given":"Qizhi","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of California San Francisco , San Francisco, CA 94143"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tippi C","family":"MacKenzie","sequence":"additional","affiliation":[{"name":"Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco , San Francisco, CA 94143"},{"name":"Department of Surgery, University of California San Francisco , San Francisco, CA 94143"},{"name":"Department of Pediatrics, University of California San Francisco , San Francisco, CA 94143"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,6,15]]},"reference":[{"key":"2025030702182922900_r1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nature13158","article-title":"Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity","volume":"508","author":"van de Pavert","year":"2014","journal-title":"Nature"},{"key":"2025030702182922900_r2","doi-asserted-by":"crossref","first-page":"4383","DOI":"10.1182\/blood-2012-06-437566","article-title":"Memory CD4+CCR5+ T cells are abundantly present in the gut of newborn infants to facilitate mother-to-child transmission of HIV-1","volume":"120","author":"Bunders","year":"2012","journal-title":"Blood"},{"key":"2025030702182922900_r3","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1038\/nm.3670","article-title":"Interleukin-8 (CXCL8) production is a signatory T cell effector function of human newborn infants","volume":"20","author":"Gibbons","year":"2014","journal-title":"Nat. Med."},{"key":"2025030702182922900_r4","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.siny.2011.02.003","article-title":"Neonatal abdominal wall defects","volume":"16","author":"Christison-Lagay","year":"2011","journal-title":"Semin. Fetal Neonatal Med."},{"key":"2025030702182922900_r5","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1203\/01.pdr.0000242344.22638.94","article-title":"Biochemical investigations of bowel inflammation in gastroschisis","volume":"60","author":"Guibourdenche","year":"2006","journal-title":"Pediatr. Res."},{"key":"2025030702182922900_r6","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1111\/j.1471-0528.1998.tb09975.x","article-title":"Intra-amniotic inflammation in human gastroschisis: possible aetiology of postnatal bowel dysfunction","volume":"105","author":"Morrison","year":"1998","journal-title":"Br. J. Obstet. Gynaecol."},{"key":"2025030702182922900_r7","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1007\/s00404-012-2394-3","article-title":"The prevalence of preterm births in pregnancies complicated with fetal gastroschisis","volume":"286","author":"Barseghyan","year":"2012","journal-title":"Arch. Gynecol. Obstet."},{"key":"2025030702182922900_r8","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1097\/AOG.0000000000000425","article-title":"Factors associated with gastroschisis outcomes","volume":"124","author":"Overcash","year":"2014","journal-title":"Obstet. Gynecol."},{"key":"2025030702182922900_r9","doi-asserted-by":"crossref","first-page":"5256","DOI":"10.1128\/MCB.21.15.5256-5261.2001","article-title":"Impaired abdominal wall development and deficient wound healing in mice lacking aortic carboxypeptidase-like protein","volume":"21","author":"Layne","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"2025030702182922900_r10","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/pr.2013.98","article-title":"Fetal production of growth factors and inflammatory mediators predicts pulmonary hypertension in congenital diaphragmatic hernia","volume":"74","author":"Fleck","year":"2013","journal-title":"Pediatr. Res."},{"key":"2025030702182922900_r11","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1309\/AJCPE89ZPVJTSPWL","article-title":"Gastrointestinal pathology in celiac disease: a case series of 150 consecutive newly diagnosed patients","volume":"138","author":"Brown","year":"2012","journal-title":"Am. J. Clin. Pathol."},{"key":"2025030702182922900_r12","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1136\/gutjnl-2011-301551","article-title":"Necrotising enterocolitis is characterised by disrupted immune regulation and diminished mucosal regulatory (FOXP3)\/effector (CD4, CD8) T cell ratios","volume":"62","author":"Weitkamp","year":"2013","journal-title":"Gut"},{"key":"2025030702182922900_r13","doi-asserted-by":"crossref","first-page":"5756","DOI":"10.4049\/jimmunol.170.11.5756","article-title":"Marked airway eosinophilia prevents development of airway hyper-responsiveness during an allergic response in IL-5 transgenic mice","volume":"170","author":"Kobayashi","year":"2003","journal-title":"J. Immunol."},{"key":"2025030702182922900_r14","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1002\/(SICI)1521-4141(199807)28:07<2092::AID-IMMU2092>3.0.CO;2-E","article-title":"Comparative studies of rat IgG to further delineate the Fc:FcRn interaction site","volume":"28","author":"Medesan","year":"1998","journal-title":"Eur. J. Immunol."},{"issue":"47","key":"2025030702182922900_r15","first-page":"pii: 2303","article-title":"A mouse model of in utero transplantation","volume":"2011","author":"Nijagal","year":"2011","journal-title":"J. Vis. Exp."},{"key":"2025030702182922900_r16","doi-asserted-by":"crossref","first-page":"4595","DOI":"10.1182\/blood-2012-10-463174","article-title":"Direct and indirect antigen presentation lead to deletion of donor-specific T cells after in utero hematopoietic cell transplantation in mice","volume":"121","author":"Nijagal","year":"2013","journal-title":"Blood"},{"key":"2025030702182922900_r17","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1182\/blood-2014-02-550327","article-title":"In utero depletion of fetal hematopoietic stem cells improves engraftment after neonatal transplantation in mice","volume":"124","author":"Derderian","year":"2014","journal-title":"Blood"},{"key":"2025030702182922900_r18","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/1074-7613(94)90045-0","article-title":"Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells","volume":"1","author":"Powrie","year":"1994","journal-title":"Immunity"},{"key":"2025030702182922900_r19","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/nri2340","article-title":"The genetics and immunopathogenesis of inflammatory bowel disease","volume":"8","author":"Cho","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"2025030702182922900_r20","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1084\/jem.20081712","article-title":"Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation","volume":"206","author":"Kleinschek","year":"2009","journal-title":"J. Exp. Med."},{"key":"2025030702182922900_r21","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/ni1496","article-title":"Interleukins 1\u03b2 and 6 but not transforming growth factor-\u03b2 are essential for the differentiation of interleukin 17-producing human T helper cells","volume":"8","author":"Acosta-Rodriguez","year":"2007","journal-title":"Nat. Immunol."},{"key":"2025030702182922900_r22","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/44385","article-title":"Two subsets of memory T lymphocytes with distinct homing potentials and effector functions","volume":"401","author":"Sallusto","year":"1999","journal-title":"Nature"},{"key":"2025030702182922900_r23","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1126\/science.1164511","article-title":"Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero","volume":"322","author":"Mold","year":"2008","journal-title":"Science"},{"key":"2025030702182922900_r24","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/tera.1420330303","article-title":"The natural history of gastroschisis during fetal life: development of the fibrous coating on the bowel loops","volume":"33","author":"Tibboel","year":"1986","journal-title":"Teratology"},{"key":"2025030702182922900_r25","doi-asserted-by":"crossref","first-page":"3521","DOI":"10.1111\/j.1572-0241.1999.01641.x","article-title":"Immunnohistological assessment of intestinal eosinophil activation in patients with eosinophilic gastroenteritis and inflammatory bowel disease","volume":"94","author":"Bischoff","year":"1999","journal-title":"Am. J. Gastroenterol."},{"key":"2025030702182922900_r26","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1203\/PDR.0b013e3181e17c75","article-title":"Gastroschisis in mice lacking aortic carboxypeptidase-like protein is associated with a defect in neuromuscular development of the eviscerated intestine","volume":"68","author":"Danzer","year":"2010","journal-title":"Pediatr. Res."},{"key":"2025030702182922900_r27","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S1074-7613(00)80371-4","article-title":"Developing lymph nodes collect CD4+CD3\u2212 LT\u03b2+ cells that can differentiate to APC, NK cells, and follicular cells but not T or B cells","volume":"7","author":"Mebius","year":"1997","journal-title":"Immunity"},{"key":"2025030702182922900_r28","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/ni1022","article-title":"An essential function for the nuclear receptor ROR\u03b3t in the generation of fetal lymphoid tissue inducer cells","volume":"5","author":"Eberl","year":"2004","journal-title":"Nat. Immunol."},{"key":"2025030702182922900_r29","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/ni.3057","article-title":"Identification and distribution of developing innate lymphoid cells in the fetal mouse intestine","volume":"16","author":"Bando","year":"2015","journal-title":"Nat. Immunol."},{"key":"2025030702182922900_r30","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/nature12526","article-title":"Type 2 innate lymphoid cells control eosinophil homeostasis","volume":"502","author":"Nussbaum","year":"2013","journal-title":"Nature"},{"key":"2025030702182922900_r31","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1038\/nature08949","article-title":"Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology","volume":"464","author":"Buonocore","year":"2010","journal-title":"Nature"},{"key":"2025030702182922900_r32","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nri3365","article-title":"Innate lymphoid cells\u2014a proposal for uniform nomenclature","volume":"13","author":"Spits","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"2025030702182922900_r33","doi-asserted-by":"crossref","first-page":"3572","DOI":"10.1182\/blood-2014-07-587493","article-title":"Interleukin-5-producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy","volume":"124","author":"Van Gool","year":"2014","journal-title":"Blood"},{"key":"2025030702182922900_r34","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.jpedsurg.2008.10.084","article-title":"Closing gastroschisis: diagnosis, management, and outcomes","volume":"44","author":"Houben","year":"2009","journal-title":"J. Pediatr. Surg."},{"key":"2025030702182922900_r35","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/S0041-1345(00)01231-8","article-title":"Impact of intestinal ischemia-reperfusion on cytokine profile and enterocyte viability in human syngeneic intestinal transplantation","volume":"32","author":"Kadry","year":"2000","journal-title":"Transplant. Proc."},{"key":"2025030702182922900_r36","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.clim.2008.09.019","article-title":"IL-17 producing CD4+ T cells mediate accelerated ischemia\/reperfusion-induced injury in autoimmunity-prone mice","volume":"130","author":"Edgerton","year":"2009","journal-title":"Clin. Immunol."},{"key":"2025030702182922900_r37","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.surg.2012.03.001","article-title":"Treatment with antithymocyte globulin ameliorates intestinal ischemia and reperfusion injury in mice","volume":"152","author":"Watson","year":"2012","journal-title":"Surgery"},{"key":"2025030702182922900_r38","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/ni.2104","article-title":"Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161","volume":"12","author":"Mj\u00f6sberg","year":"2011","journal-title":"Nat. Immunol."},{"key":"2025030702182922900_r39","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1182\/blood-2013-11-427781","article-title":"Human innate lymphoid cells","volume":"124","author":"Hazenberg","year":"2014","journal-title":"Blood"},{"key":"2025030702182922900_r40","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1084\/jem.169.4.1277","article-title":"Human lymphocytes bearing T cell receptor \u03b3\/\u03b4 are phenotypically diverse and evenly distributed throughout the lymphoid system","volume":"169","author":"Groh","year":"1989","journal-title":"J. Exp. Med."},{"key":"2025030702182922900_r41","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nature08636","article-title":"Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells","volume":"463","author":"Moro","year":"2010","journal-title":"Nature"},{"key":"2025030702182922900_r42","doi-asserted-by":"crossref","first-page":"11489","DOI":"10.1073\/pnas.1003988107","article-title":"Systemically dispersed innate IL-13-expressing cells in type 2 immunity","volume":"107","author":"Price","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030702182922900_r43","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nature08900","article-title":"Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity","volume":"464","author":"Neill","year":"2010","journal-title":"Nature"},{"key":"2025030702182922900_r44","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/nm.3892","article-title":"Innate lymphoid cells in the initiation, regulation and resolution of inflammation","volume":"21","author":"Sonnenberg","year":"2015","journal-title":"Nat. Med."},{"key":"2025030702182922900_r45","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1126\/science.1222551","article-title":"Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria","volume":"336","author":"Sonnenberg","year":"2012","journal-title":"Science"},{"key":"2025030702182922900_r46","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nature12240","article-title":"Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria","volume":"498","author":"Hepworth","year":"2013","journal-title":"Nature"},{"key":"2025030702182922900_r47","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1203\/01.PDR.0000134251.45878.D5","article-title":"Early intestinal bacterial colonization and necrotizing enterocolitis in premature infants: the putative role of Clostridium","volume":"56","author":"de la Cochetiere","year":"2004","journal-title":"Pediatr. Res."},{"key":"2025030702182922900_r48","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.1111\/j.1572-0241.1999.01640.x","article-title":"Fecal eosinophil granule-derived proteins reflect disease activity in inflammatory bowel disease","volume":"94","author":"Saitoh","year":"1999","journal-title":"Am. J. Gastroenterol."},{"key":"2025030702182922900_r49","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1023\/A:1018843104511","article-title":"Eosinophil activation in ulcerative colitis: studies on mucosal release and localization of eosinophil granule constituents","volume":"43","author":"Raab","year":"1998","journal-title":"Dig. Dis. Sci."},{"key":"2025030702182922900_r50","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/S0960-9822(06)00371-X","article-title":"Functional expression of the eotaxin receptor CCR3 in T lymphocytes co-localizing with eosinophils","volume":"7","author":"Gerber","year":"1997","journal-title":"Curr. Biol."},{"key":"2025030702182922900_r51","doi-asserted-by":"crossref","first-page":"e64216","DOI":"10.1371\/journal.pone.0064216","article-title":"Activated eosinophils in association with enteric nerves in inflammatory bowel disease","volume":"8","author":"Smyth","year":"2013","journal-title":"PLoS One"},{"key":"2025030702182922900_r52","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1111\/j.1365-2982.2006.00841.x","article-title":"Different susceptibilities of spontaneous rhythmicity and myogenic contractility to intestinal muscularis inflammation in the hapten-induced colitis","volume":"18","author":"Kiyosue","year":"2006","journal-title":"Neurogastroenterol. Motil."},{"key":"2025030702182922900_r53","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1582-4934.2008.00277.x","article-title":"Delayed development of interstitial cells of Cajal in the ileum of a human case of gastroschisis","volume":"12","author":"Midrio","year":"2008","journal-title":"J. Cell. Mol. Med."},{"key":"2025030702182922900_r54","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/S0002-9378(98)70272-8","article-title":"The fetal inflammatory response syndrome","volume":"179","author":"Gomez","year":"1998","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2025030702182922900_r55","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.jpedsurg.2006.12.029","article-title":"Amnioexchange for fetuses with gastroschisis: is it effective?","volume":"42","author":"Midrio","year":"2007","journal-title":"J. Pediatr. Surg."}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/196\/12\/4957\/62256166\/1502587.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/196\/12\/4957\/62256166\/1502587.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T02:44:18Z","timestamp":1741315458000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/196\/12\/4957\/7964263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":55,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,6,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1502587","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2016,6]]},"published":{"date-parts":[[2016,6]]}}}