{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:38:21Z","timestamp":1791275901508,"version":"4.1.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Failure of the immune system to eradicate viruses results in chronic viral infections, which are associated with increased susceptibility to secondary infections. Pathogenic HIV or lymphocytic choriomeningitis virus chronic infections display a persistent type I IFN signature. In chronic lymphocytic choriomeningitis virus infection, blockade of type I IFN signaling partially restores antiviral responses. In a mouse model, we tested whether chronic administration of type I IFN, at doses mimicking chronic viral infection, induced immunosuppression. Chronic exposure of mice to IFN-\u03b1 alone was sufficient to strongly suppress specific CD8+ T cells responses to subsequent vaccinia virus infection. It resulted in the accumulation of Ly6Chi monocytes. These monocytes were similar, phenotypically and functionally, to the myeloid-derived suppressor cells found in cancer because they exerted a potent suppression on CD8+ T cell responses in vitro. They acted at least partly through the l-arginine pathway. In vivo, their elimination restored antiviral CD8+ T cell responses. Our work provides a specific mechanism accounting for the role of IFN-\u03b1 in immunosuppression and predicts that type I IFN modulation will be pivotal to cure human chronic infections, cancer, or autoimmune diseases.<\/jats:p>","DOI":"10.4049\/jimmunol.1502638","type":"journal-article","created":{"date-parts":[[2016,12,22]],"date-time":"2016-12-22T02:11:32Z","timestamp":1482372692000},"page":"1156-1163","source":"Crossref","is-referenced-by-count":53,"title":["Chronic Type I IFN Is Sufficient To Promote Immunosuppression through Accumulation of Myeloid-Derived Suppressor Cells"],"prefix":"10.1093","volume":"198","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2560-2230","authenticated-orcid":false,"given":"Kahina","family":"Taleb","sequence":"first","affiliation":[{"name":"INSERM, U1016, Institut Cochin , 75014 Paris, ; , 75014 Paris, ; and , Sorbonne Paris Cit\u00e9, 75014 Paris,","place":["France France France"]},{"name":"CNRS UMR8104 , 75014 Paris, ; , 75014 Paris, ; and , Sorbonne Paris Cit\u00e9, 75014 Paris,","place":["France France France"]},{"name":"Universit\u00e9 Paris Descartes , 75014 Paris, ; , 75014 Paris, ; and , Sorbonne Paris Cit\u00e9, 75014 Paris,","place":["France France France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9dric","family":"Auffray","sequence":"additional","affiliation":[{"name":"INSERM, U1016, Institut Cochin , 75014 Paris, ; , 75014 Paris, ; and , Sorbonne Paris Cit\u00e9, 75014 Paris,","place":["France France France"]},{"name":"CNRS UMR8104 , 75014 Paris, ; , 75014 Paris, ; and , Sorbonne Paris Cit\u00e9, 75014 Paris,","place":["France France France"]},{"name":"Universit\u00e9 Paris Descartes , 75014 Paris, ; , 75014 Paris, ; and , Sorbonne Paris Cit\u00e9, 75014 Paris,","place":["France France France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Villefroy","sequence":"additional","affiliation":[{"name":"INSERM, U1016, Institut Cochin , 75014 Paris, ; , 75014 Paris, ; and , Sorbonne Paris Cit\u00e9, 75014 Paris,","place":["France France France"]},{"name":"CNRS UMR8104 , 75014 Paris, ; , 75014 Paris, ; and , Sorbonne Paris Cit\u00e9, 75014 Paris,","place":["France France France"]},{"name":"Universit\u00e9 Paris Descartes , 75014 Paris, ; , 75014 Paris, ; and , Sorbonne Paris Cit\u00e9, 75014 Paris,","place":["France France France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9688-8232","authenticated-orcid":false,"given":"Adrien","family":"Pereira","sequence":"additional","affiliation":[{"name":"INSERM, U1016, Institut Cochin , 75014 Paris, ; , 75014 Paris, ; and , Sorbonne Paris Cit\u00e9, 75014 Paris,","place":["France France France"]},{"name":"CNRS UMR8104 , 75014 Paris, ; , 75014 Paris, ; and , Sorbonne Paris Cit\u00e9, 75014 Paris,","place":["France France France"]},{"name":"Universit\u00e9 Paris Descartes , 75014 Paris, ; , 75014 Paris, ; and , Sorbonne Paris Cit\u00e9, 75014 Paris,","place":["France France France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9021-3488","authenticated-orcid":false,"given":"Anne","family":"Hosmalin","sequence":"additional","affiliation":[{"name":"INSERM, U1016, Institut Cochin , 75014 Paris, ; , 75014 Paris, ; and , Sorbonne Paris Cit\u00e9, 75014 Paris,","place":["France France France"]},{"name":"CNRS UMR8104 , 75014 Paris, ; , 75014 Paris, ; and , Sorbonne Paris Cit\u00e9, 75014 Paris,","place":["France France France"]},{"name":"Universit\u00e9 Paris Descartes , 75014 Paris, ; , 75014 Paris, ; and , Sorbonne Paris Cit\u00e9, 75014 Paris,","place":["France France France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Gaudry","sequence":"additional","affiliation":[{"name":"INSERM, U1016, Institut Cochin , 75014 Paris, ; , 75014 Paris, ; and , Sorbonne Paris Cit\u00e9, 75014 Paris,","place":["France France France"]},{"name":"CNRS UMR8104 , 75014 Paris, ; , 75014 Paris, ; and , Sorbonne Paris Cit\u00e9, 75014 Paris,","place":["France France France"]},{"name":"Universit\u00e9 Paris Descartes , 75014 Paris, ; , 75014 Paris, ; and , Sorbonne Paris Cit\u00e9, 75014 Paris,","place":["France France France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4204-8136","authenticated-orcid":false,"given":"Agn\u00e8s","family":"Le Bon","sequence":"additional","affiliation":[{"name":"INSERM, U1016, Institut Cochin , 75014 Paris, ; 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