{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T00:13:35Z","timestamp":1793664815323,"version":"4.5.1"},"reference-count":90,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>CD74 mediates MHC class-II antigenic peptide loading and presentation and plays an important role in the pathogenesis of autoimmune diseases, including systemic lupus erythematosus. C57BL\/6 Faslpr mice that develop spontaneous lupus-like autoimmunity and pathology showed elevated CD74 expression in the inflammatory cell infiltrates and the adjacent tubular epithelial cells (TECs) in kidneys affected by lupus nephritis but negligible levels in kidneys from age-matched wild-type mice. The inflammatory cytokine IFN-\u03b3 or IL-6 induced CD74 expression in kidney TECs in vitro. The presence of kidney TECs from Faslpr mice, rather than from wild-type mice, produced significantly stronger histones, dsDNA, and ribonucleoprotein-Smith Ag complex\u2013induced CD4+ T cell activation. Splenocytes from CD74-deficient FaslprCd74\u2212\/\u2212 mice had muted responses in a MLR and to the autoantigen histones. Compared with FaslprCd74+\/+ mice, FaslprCd74\u2212\/\u2212 mice had reduced kidney and spleen sizes, splenic activated T cells and B cells, serum IgG and autoantibodies, urine albumin\/creatinine ratio, kidney Periodic acid\u2013Schiff score, IgG and C3 deposition, and serum IL-6 and IL-17A levels, but serum IL-2 and TGF-\u03b2 levels were increased. Study of chronic graft-versus-host C57BL\/6 mice that received donor splenocytes from B6.C-H2bm12\/KhEg mice and those that received syngeneic donor splenocytes yielded similar observations. CD74 deficiency reduced lupus-like autoimmunity and kidney pathology in chronic graft-versus-host mice. This investigation establishes the direct participation of CD74 in autoimmunity and highlights a potential role for CD74 in kidney TECs, together with professional APCs in systemic lupus erythematosus.<\/jats:p>","DOI":"10.4049\/jimmunol.1600028","type":"journal-article","created":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T14:41:44Z","timestamp":1510238504000},"page":"2568-2577","source":"Crossref","is-referenced-by-count":26,"title":["CD74 Deficiency Mitigates Systemic Lupus Erythematosus\u2013like Autoimmunity and Pathological Findings in Mice"],"prefix":"10.1093","volume":"198","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3425-2404","authenticated-orcid":false,"given":"Yi","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Nephrology, The First Affiliated Hospital, Sun Yat-Sen University , Guangzhou 510080,","place":["China"]},{"name":"Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA 02115"},{"name":"Research Institute of Nephrology, Nanjing University School of Medicine , Nanjing 210002,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7649-8904","authenticated-orcid":false,"given":"Li","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA 02115"},{"name":"Department of Biology, School of Life Science, Huzhou Teachers College , Huzhou, Zhejiang 313000,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqing","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, The First Affiliated Hospital, Sun Yat-Sen University , Guangzhou 510080,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galina K","family":"Sukhova","sequence":"additional","affiliation":[{"name":"Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Nan Fang Hospital, Southern Medical University , Guangzhou 510515,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasileios C","family":"Kyttaris","sequence":"additional","affiliation":[{"name":"Department of Medicine, Beth Israel Deaconess Medical Center, Harvard 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