{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:55:59Z","timestamp":1777654559660,"version":"3.51.4"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>IL-33, required for viral clearance by cytotoxic T cells, is generally expressed in vascular endothelial cells in healthy human tissues. We discovered that endothelial IL-33 expression was stimulated as a response to adenoviral transduction. This response was dependent on MRE11, a sensor of DNA damage that can also be activated by adenoviral DNA, and on IRF1, a transcriptional regulator of cellular responses to viral invasion and DNA damage. Accordingly, we observed that endothelial cells responded to adenoviral DNA by phosphorylation of ATM and CHK2 and that depletion or inhibition of MRE11, but not depletion of ATM, abrogated IL-33 stimulation. In conclusion, we show that adenoviral transduction stimulates IL-33 expression in endothelial cells in a manner that is dependent on the DNA-binding protein MRE11 and the antiviral factor IRF1 but not on downstream DNA damage response signaling.<\/jats:p>","DOI":"10.4049\/jimmunol.1600054","type":"journal-article","created":{"date-parts":[[2017,3,4]],"date-time":"2017-03-04T01:50:20Z","timestamp":1488592220000},"page":"3318-3325","source":"Crossref","is-referenced-by-count":7,"title":["Endothelial IL-33 Expression Is Augmented by Adenoviral Activation of the DNA Damage Machinery"],"prefix":"10.1093","volume":"198","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1554-4775","authenticated-orcid":false,"given":"Tor Espen","family":"Stav-Noraas","sequence":"first","affiliation":[{"name":"K.G. Jebsen Inflammation Research Centre, Oslo University Hospital and University of Oslo , N-0424 Oslo,","place":["Norway"]},{"name":"Laboratory of Immunohistochemistry and Immunopathology, Department of Pathology, Oslo University Hospital and University of Oslo , N-0424 Oslo,","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9077-164X","authenticated-orcid":false,"given":"Reidunn J","family":"Edelmann","sequence":"additional","affiliation":[{"name":"K.G. Jebsen Inflammation Research Centre, Oslo University Hospital and University of Oslo , N-0424 Oslo,","place":["Norway"]},{"name":"Laboratory of Immunohistochemistry and Immunopathology, Department of Pathology, Oslo University Hospital and University of Oslo , N-0424 Oslo,","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7266-3108","authenticated-orcid":false,"given":"Lars La Cour","family":"Poulsen","sequence":"additional","affiliation":[{"name":"K.G. Jebsen Inflammation Research Centre, Oslo University Hospital and University of Oslo , N-0424 Oslo,","place":["Norway"]},{"name":"Laboratory of Immunohistochemistry and Immunopathology, Department of Pathology, Oslo University Hospital and University of Oslo , N-0424 Oslo,","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4930-3227","authenticated-orcid":false,"given":"Olav","family":"Sundnes","sequence":"additional","affiliation":[{"name":"K.G. Jebsen Inflammation Research Centre, Oslo University Hospital and University of Oslo , N-0424 Oslo,","place":["Norway"]},{"name":"Laboratory of Immunohistochemistry and Immunopathology, Department of Pathology, Oslo University Hospital and University of Oslo , N-0424 Oslo,","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8725-1563","authenticated-orcid":false,"given":"Danh","family":"Phung","sequence":"additional","affiliation":[{"name":"Laboratory of Immunohistochemistry and Immunopathology, Department of Pathology, Oslo University Hospital and University of Oslo , N-0424 Oslo,","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4512-1079","authenticated-orcid":false,"given":"Axel M","family":"K\u00fcchler","sequence":"additional","affiliation":[{"name":"Laboratory of Immunohistochemistry and Immunopathology, Department of Pathology, Oslo University Hospital and University of Oslo , N-0424 Oslo,","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0812-0640","authenticated-orcid":false,"given":"Fredrik","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Oslo University Hospital and University of Oslo , N-0424 Oslo,","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9110-8815","authenticated-orcid":false,"given":"Amine A","family":"Kamen","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, McGill University , Montreal, Quebec H3A OC3,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guttorm","family":"Haraldsen","sequence":"additional","affiliation":[{"name":"K.G. Jebsen Inflammation Research Centre, Oslo University Hospital and University of Oslo , N-0424 Oslo,","place":["Norway"]},{"name":"Laboratory of Immunohistochemistry and Immunopathology, Department of Pathology, Oslo University Hospital and University of Oslo , N-0424 Oslo,","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari","family":"Kaarb\u00f8","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Oslo University Hospital and University of Oslo , N-0424 Oslo,","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5837-5006","authenticated-orcid":false,"given":"Johanna","family":"Hol","sequence":"additional","affiliation":[{"name":"K.G. Jebsen Inflammation Research Centre, Oslo University Hospital and University of Oslo , N-0424 Oslo,","place":["Norway"]},{"name":"Laboratory of Immunohistochemistry and Immunopathology, Department of Pathology, Oslo University Hospital and University of Oslo , N-0424 Oslo,","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,4,15]]},"reference":[{"key":"2025030615090227900_r1","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.immuni.2005.09.015","article-title":"IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines","volume":"23","author":"Schmitz","year":"2005","journal-title":"Immunity"},{"key":"2025030615090227900_r2","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.it.2009.03.003","article-title":"Interleukin-33 - cytokine of dual function or novel alarmin?","volume":"30","author":"Haraldsen","year":"2009","journal-title":"Trends Immunol."},{"key":"2025030615090227900_r3","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1126\/science.1215418","article-title":"The alarmin interleukin-33 drives protective antiviral CD8+ T cell responses","volume":"335","author":"Bonilla","year":"2012","journal-title":"Science"},{"key":"2025030615090227900_r4","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1165\/rcmb.2010-0516OC","article-title":"Infection with influenza virus induces IL-33 in murine lungs","volume":"45","author":"Le Goffic","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2025030615090227900_r5","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1089\/jir.2011.0109","article-title":"Serum IL-33 levels are associated with liver damage in patients with chronic hepatitis B","volume":"32","author":"Wang","year":"2012","journal-title":"J. Interferon Cytokine Res."},{"key":"2025030615090227900_r6","doi-asserted-by":"crossref","first-page":"50","DOI":"10.4049\/jimmunol.1003554","article-title":"Transcriptional regulation of murine IL-33 by TLR and non-TLR agonists","volume":"189","author":"Polumuri","year":"2012","journal-title":"J. Immunol."},{"key":"2025030615090227900_r7","doi-asserted-by":"crossref","first-page":"e74278","DOI":"10.1371\/journal.pone.0074278","article-title":"Pathogenic mouse hepatitis virus or poly(I:C) induce IL-33 in hepatocytes in murine models of hepatitis","volume":"8","author":"Arshad","year":"2013","journal-title":"PLoS One"},{"key":"2025030615090227900_r8","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.2353\/ajpath.2010.100378","article-title":"Inflammatory bowel disease\u2013associated interleukin-33 is preferentially expressed in ulceration-associated myofibroblasts","volume":"177","author":"Sponheim","year":"2010","journal-title":"Am. J. Pathol."},{"key":"2025030615090227900_r9","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1089\/hum.2014.001","article-title":"Innate immunity to adenovirus","volume":"25","author":"Hendrickx","year":"2014","journal-title":"Hum. Gene Ther."},{"key":"2025030615090227900_r10","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1038\/mt.2010.124","article-title":"Recognition of virus infection and innate host responses to viral gene therapy vectors","volume":"18","author":"Shayakhmetov","year":"2010","journal-title":"Mol. Ther."},{"key":"2025030615090227900_r11","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1146\/annurev.micro.112408.134016","article-title":"Genomes in conflict: maintaining genome integrity during virus infection","volume":"64","author":"Weitzman","year":"2010","journal-title":"Annu. Rev. Microbiol."},{"key":"2025030615090227900_r12","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/nature00863","article-title":"Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex","volume":"418","author":"Stracker","year":"2002","journal-title":"Nature"},{"key":"2025030615090227900_r13","doi-asserted-by":"crossref","first-page":"6207","DOI":"10.1128\/JVI.79.10.6207-6215.2005","article-title":"Relocalization of the Mre11-Rad50-Nbs1 complex by the adenovirus E4 ORF3 protein is required for viral replication","volume":"79","author":"Evans","year":"2005","journal-title":"J. Virol."},{"key":"2025030615090227900_r14","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.2353\/ajpath.2008.080014","article-title":"Nuclear interleukin-33 is generally expressed in resting endothelium but rapidly lost upon angiogenic or proinflammatory activation","volume":"173","author":"K\u00fcchler","year":"2008","journal-title":"Am. J. Pathol."},{"key":"2025030615090227900_r15","doi-asserted-by":"crossref","first-page":"e3331","DOI":"10.1371\/journal.pone.0003331","article-title":"The IL-1\u2013like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel \u2018alarmin\u2019?","volume":"3","author":"Moussion","year":"2008","journal-title":"PLoS One"},{"key":"2025030615090227900_r16","doi-asserted-by":"crossref","first-page":"3488","DOI":"10.4049\/jimmunol.1101977","article-title":"Endogenous IL-33 is highly expressed in mouse epithelial barrier tissues, lymphoid organs, brain, embryos, and inflamed tissues: in situ analysis using a novel Il-33-LacZ gene trap reporter strain","volume":"188","author":"Pichery","year":"2012","journal-title":"J. Immunol."},{"key":"2025030615090227900_r17","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1093\/nar\/gkn1051","article-title":"A ChIP-chip approach reveals a novel role for transcription factor IRF1 in the DNA damage response","volume":"37","author":"Frontini","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"2025030615090227900_r18","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1172\/JCI107470","article-title":"Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria","volume":"52","author":"Jaffe","year":"1973","journal-title":"J. Clin. Invest."},{"key":"2025030615090227900_r19","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1002\/bit.22113","article-title":"An efficient and scalable process for helper-dependent adenoviral vector production using polyethylenimine-adenofection","volume":"102","author":"Dormond","year":"2009","journal-title":"Biotechnol. Bioeng."},{"key":"2025030615090227900_r20","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"2025030615090227900_r21","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc."},{"key":"2025030615090227900_r22","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.ajpath.2012.06.003","article-title":"The alarmin IL-33 is a notch target in quiescent endothelial cells","volume":"181","author":"Sundlisaeter","year":"2012","journal-title":"Am. J. Pathol."},{"key":"2025030615090227900_r23","doi-asserted-by":"crossref","first-page":"13565","DOI":"10.1073\/pnas.93.24.13565","article-title":"A helper-dependent adenovirus vector system: removal of helper virus by Cre-mediated excision of the viral packaging signal","volume":"93","author":"Parks","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030615090227900_r24","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/j.cellsig.2009.05.004","article-title":"Role of the IRF-1 enhancer domain in signalling polyubiquitination and degradation","volume":"21","author":"Pion","year":"2009","journal-title":"Cell. Signal."},{"key":"2025030615090227900_r25","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature09907","article-title":"A diverse range of gene products are effectors of the type I interferon antiviral response","volume":"472","author":"Schoggins","year":"2011","journal-title":"Nature"},{"key":"2025030615090227900_r26","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.humimm.2014.09.015","article-title":"The regulation role of interferon regulatory factor-1 gene and clinical relevance","volume":"75","author":"Dou","year":"2014","journal-title":"Hum. Immunol."},{"key":"2025030615090227900_r27","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S0092-8674(88)91307-4","article-title":"Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-beta gene regulatory elements","volume":"54","author":"Miyamoto","year":"1988","journal-title":"Cell"},{"key":"2025030615090227900_r28","doi-asserted-by":"crossref","first-page":"10895","DOI":"10.1016\/S0021-9258(18)82069-5","article-title":"Identification of a novel subunit of the type I interferon receptor localized to human chromosome 21","volume":"268","author":"Colamonici","year":"1993","journal-title":"J. Biol. Chem."},{"key":"2025030615090227900_r29","doi-asserted-by":"crossref","first-page":"5336","DOI":"10.4049\/jimmunol.1100040","article-title":"The DNA damage response induces IFN","volume":"187","author":"Brzostek-Racine","year":"2011","journal-title":"J. Immunol."},{"key":"2025030615090227900_r30","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.cell.2015.07.058","article-title":"Viral and cellular genomes activate distinct DNA damage responses","volume":"162","author":"Shah","year":"2015","journal-title":"Cell"},{"key":"2025030615090227900_r31","doi-asserted-by":"crossref","first-page":"6269","DOI":"10.1128\/JVI.00318-09","article-title":"Adeno-associated virus replication induces a DNA damage response coordinated by DNA-dependent protein kinase","volume":"83","author":"Schwartz","year":"2009","journal-title":"J. Virol."},{"key":"2025030615090227900_r32","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.1073\/pnas.1222694110","article-title":"DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking","volume":"110","author":"Kondo","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030615090227900_r33","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0092-8674(00)81547-0","article-title":"The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder","volume":"99","author":"Stewart","year":"1999","journal-title":"Cell"},{"key":"2025030615090227900_r34","doi-asserted-by":"crossref","first-page":"12881","DOI":"10.1128\/JVI.77.23.12881-12885.2003","article-title":"Development and characterization of novel empty adenovirus capsids and their impact on cellular gene expression","volume":"77","author":"Stilwell","year":"2003","journal-title":"J. Virol."},{"key":"2025030615090227900_r35","doi-asserted-by":"crossref","first-page":"12936","DOI":"10.1128\/JVI.01523-07","article-title":"The Mre11\/Rad50\/Nbs1 complex limits adeno-associated virus transduction and replication","volume":"81","author":"Schwartz","year":"2007","journal-title":"J. Virol."},{"key":"2025030615090227900_r36","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/nature12862","article-title":"Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity. [Published erratum appears in 2015 Nature 525: 144.]","volume":"505","author":"Schoggins","year":"2014","journal-title":"Nature"},{"key":"2025030615090227900_r37","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1002\/eji.201344310","article-title":"Serum amyloid A induces interleukin-33 expression through an IRF7-dependent pathway","volume":"44","author":"Sun","year":"2014","journal-title":"Eur. J. Immunol."},{"key":"2025030615090227900_r38","doi-asserted-by":"crossref","first-page":"2990","DOI":"10.1038\/ncomms3990","article-title":"Transcription factor IRF4 drives dendritic cells to promote Th2 differentiation","volume":"4","author":"Williams","year":"2013","journal-title":"Nat. Commun."},{"key":"2025030615090227900_r39","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/nri1900","article-title":"IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors","volume":"6","author":"Honda","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"2025030615090227900_r40","doi-asserted-by":"crossref","first-page":"6298","DOI":"10.1128\/MCB.24.14.6298-6310.2004","article-title":"Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells","volume":"24","author":"Oshima","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"2025030615090227900_r41","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0092-8674(00)80893-4","article-title":"The enhanceosome and transcriptional synergy","volume":"92","author":"Carey","year":"1998","journal-title":"Cell"},{"key":"2025030615090227900_r42","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/ni.3370","article-title":"Interleukin 33 is a guardian of barriers and a local alarmin","volume":"17","author":"Martin","year":"2016","journal-title":"Nat. Immunol."},{"key":"2025030615090227900_r43","doi-asserted-by":"crossref","first-page":"4056","DOI":"10.1073\/pnas.1418549112","article-title":"T-bet- and STAT4-dependent IL-33 receptor expression directly promotes antiviral Th1 cell responses","volume":"112","author":"Baumann","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030615090227900_r44","doi-asserted-by":"crossref","first-page":"9021","DOI":"10.1073\/pnas.0812690106","article-title":"The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1","volume":"106","author":"Cayrol","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030615090227900_r45","doi-asserted-by":"crossref","first-page":"e88742","DOI":"10.1371\/journal.pone.0088742","article-title":"The alarmin concept applied to human renal transplantation: evidence for a differential implication of HMGB1 and IL-33","volume":"9","author":"Thierry","year":"2014","journal-title":"PLoS One"},{"key":"2025030615090227900_r46","doi-asserted-by":"crossref","first-page":"7249","DOI":"10.1073\/pnas.1424236112","article-title":"Myocardial pressure overload induces systemic inflammation through endothelial cell IL-33","volume":"112","author":"Chen","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030615090227900_r47","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1038\/embor.2008.145","article-title":"Molecular mimicry between IL-33 and KSHV for attachment to chromatin through the H2A-H2B acidic pocket","volume":"9","author":"Roussel","year":"2008","journal-title":"EMBO Rep."},{"key":"2025030615090227900_r48","doi-asserted-by":"crossref","first-page":"20121022","DOI":"10.1098\/rsif.2012.1022","article-title":"The role of the nucleosome acidic patch in modulating higher order chromatin structure","volume":"10","author":"Kalashnikova","year":"2013","journal-title":"J. R. Soc. Interface"},{"key":"2025030615090227900_r49","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1073\/pnas.0606854104","article-title":"IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo","volume":"104","author":"Carriere","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030615090227900_r50","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.bbrc.2014.06.111","article-title":"Nuclear IL-33 regulates soluble ST2 receptor and IL-6 expression in primary human arterial endothelial cells and is decreased in idiopathic pulmonary arterial hypertension","volume":"451","author":"Shao","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2025030615090227900_r51","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.molcel.2012.06.002","article-title":"Prime, repair, restore: the active role of chromatin in the DNA damage response","volume":"46","author":"Soria","year":"2012","journal-title":"Mol. Cell"},{"key":"2025030615090227900_r52","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.virol.2012.09.023","article-title":"Snapshots: chromatin control of viral infection","volume":"435","author":"Knipe","year":"2013","journal-title":"Virology"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/198\/8\/3318\/61449003\/1600054.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/198\/8\/3318\/61449003\/1600054.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T17:23:18Z","timestamp":1741281798000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/198\/8\/3318\/7954884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":52,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,4,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.1600054","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,4]]},"published":{"date-parts":[[2017,4]]}}}