{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:41:04Z","timestamp":1790487664181,"version":"4.1.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Matrix metalloproteases (MMPs) regulate innate immunity acting over proinflammatory cytokines, chemokines, and other immune-related proteins. MMP-25 (membrane-type 6-MMP) is a membrane-bound enzyme predominantly expressed in leukocytes whose biological function has remained largely unknown. We have generated Mmp25-deficient mice to elucidate the in vivo function of this protease. These mutant mice are viable and fertile and do not show any spontaneous phenotype. However, Mmp25-null mice exhibit a defective innate immune response characterized by low sensitivity to bacterial LPS, hypergammaglobulinemia, and reduced secretion of proinflammatory molecules. Moreover, these immune defects can be tracked to a defective NF-\u03baB activation observed in Mmp25-deficient leukocytes. Globally, our findings provide new mechanistic insights into innate immunity through the activity of MMP-25, suggesting that this proteinase could be a potential therapeutic target for immune-related diseases.<\/jats:p>","DOI":"10.4049\/jimmunol.1600094","type":"journal-article","created":{"date-parts":[[2016,6,4]],"date-time":"2016-06-04T02:14:05Z","timestamp":1465006445000},"page":"296-302","source":"Crossref","is-referenced-by-count":49,"title":["MMP-25 Metalloprotease Regulates Innate Immune Response through NF-\u03baB Signaling"],"prefix":"10.1093","volume":"197","author":[{"given":"Clara","family":"Soria-Valles","sequence":"first","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Medicina, Instituto Universitario de Oncolog\u00eda, Universidad de Oviedo , 33006 Oviedo,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Guti\u00e9rrez-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Medicina, Instituto Universitario de Oncolog\u00eda, Universidad de Oviedo , 33006 Oviedo,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando G","family":"Osorio","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Medicina, Instituto Universitario de Oncolog\u00eda, Universidad de Oviedo , 33006 Oviedo,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7869-838X","authenticated-orcid":false,"given":"Dido","family":"Carrero","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Medicina, Instituto Universitario de Oncolog\u00eda, Universidad de Oviedo , 33006 Oviedo,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo A","family":"Ferrando","sequence":"additional","affiliation":[{"name":"Institute for Cancer Genetics, Columbia University , New York, NY 10032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8675-8207","authenticated-orcid":false,"given":"Enrique","family":"Colado","sequence":"additional","affiliation":[{"name":"Servivio de Hematolog\u00eda, Hospital Universitario Central de Asturias , 33011 Oviedo,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Soledad","family":"Fern\u00e1ndez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Servicio de Anatom\u00eda Patol\u00f3gica, Hospital Universitario Central de Asturias , 33011 Oviedo,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0852-7520","authenticated-orcid":false,"given":"Elena","family":"Bonzon-Kulichenko","sequence":"additional","affiliation":[{"name":"Laboratorio de Prote\u00f3mica Cardiovascular, Centro Nacional de Investigaciones Cardiovasculares , 28029 Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1461-5092","authenticated-orcid":false,"given":"Jes\u00fas","family":"V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Laboratorio de Prote\u00f3mica Cardiovascular, Centro Nacional de Investigaciones Cardiovasculares , 28029 Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Fueyo","sequence":"additional","affiliation":[{"name":"\u00c1rea de Fisiolog\u00eda, Departamento de Biolog\u00eda Funcional, Facultad de Medicina, Instituto Universitario de Oncolog\u00eda, Universidad de Oviedo , 33006 Oviedo,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"L\u00f3pez-Ot\u00edn","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Medicina, Instituto Universitario de Oncolog\u00eda, Universidad de Oviedo , 33006 Oviedo,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,7,1]]},"reference":[{"key":"2025030617452104600_r1","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1182\/blood-2014-03-562710","article-title":"Resolution of acute inflammation bridges the gap between innate and adaptive immunity","volume":"124","author":"Newson","year":"2014","journal-title":"Blood"},{"key":"2025030617452104600_r2","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/nrm3904","article-title":"Remodelling the extracellular matrix in development and disease","volume":"15","author":"Bonnans","year":"2014","journal-title":"Nat. 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