{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T07:42:01Z","timestamp":1772696521279,"version":"3.50.1"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Steroid receptor coactivator 3 (SRC-3) is a transcriptional coactivator that interacts with nuclear receptors and some other transcription factors to enhance their effects on target gene transcription. We reported previously that SRC-3\u2013deficient (SRC-3\u2212\/\u2212) mice are extremely susceptible to Escherichia coli\u2013induced septic peritonitis as a result of uncontrolled inflammation and a defect in bacterial clearance. In this study, we observed significant upregulation of SRC-3 in colonic epithelial cells in response to Citrobacter rodentium infection. Based on these findings, we hypothesized that SRC-3 is involved in host defense against attaching and effacing bacterial infection. We compared the responses of SRC-3\u2212\/\u2212 and wild-type mice to intestinal C. rodentium infection. We found that SRC-3\u2212\/\u2212 mice exhibited delayed clearance of C. rodentium and more severe tissue pathology after oral infection with C. rodentium compared with wild-type mice. SRC-3\u2212\/\u2212 mice expressed normal antimicrobial peptides in the colons but exhibited delayed recruitment of neutrophils into the colonic mucosa. Accordingly, SRC-3\u2212\/\u2212 mice showed a delayed induction of CXCL2 and CXCL5 in colonic epithelial cells, which are responsible for neutrophil recruitment. At the molecular level, we found that SRC-3 can activate the NF-\u03baB signaling pathway to promote CXCL2 expression at the transcriptional level. Collectively, we show that SRC-3 contributes to host defense against enteric bacteria, at least in part via upregulating CXCL2 expression to recruit neutrophils.<\/jats:p>","DOI":"10.4049\/jimmunol.1600300","type":"journal-article","created":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T02:20:25Z","timestamp":1483582825000},"page":"1606-1615","source":"Crossref","is-referenced-by-count":12,"title":["Steroid Receptor Coactivator 3 Contributes to Host Defense against Enteric Bacteria by Recruiting Neutrophils via Upregulation of CXCL2 Expression"],"prefix":"10.1093","volume":"198","author":[{"given":"Wenbo","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University , Xiamen 361102,","place":["China"]},{"name":"The First Affiliated Hospital of Xiamen University , Xiamen 361001,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuqiang","family":"Lu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University , Xiamen 361102,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University , Xiamen 361102,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University , Xiamen 361102,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pingli","family":"Mo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University , Xiamen 361102,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhangwei","family":"Tong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University , Xiamen 361102,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University , Xiamen 361102,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University , Xiamen 361102,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8833-3931","authenticated-orcid":false,"given":"Guoqiang","family":"Su","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Xiamen University , Xiamen 361001,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianming","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, Baylor College of Medicine , Houston, TX 77030"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4141-8345","authenticated-orcid":false,"given":"Chundong","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University , Xiamen 361102,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,2,15]]},"reference":[{"key":"2025030615031763500_r1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jcpa.2004.09.005","article-title":"Attaching-effacing bacteria in animals","volume":"132","author":"Wales","year":"2005","journal-title":"J. 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