{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:33:34Z","timestamp":1790728414899,"version":"4.1.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>IL-35 downregulates Th17 cell development and suppresses certain types of autoimmune inflammation such as collagen-induced arthritis and experimental autoimmune uveitis. Psoriasis is thought to be initiated by abnormal interactions between cutaneous keratinocytes and systemic immune cells. However, the role of IL-35 in psoriasis remains unclear. In this study, we assessed IL-35 in three well-known psoriasis models: a human keratinocyte cell line (HaCaT), a keratin 14 (K14)-vascular endothelial growth factor A (VEGF-A)-transgenic (Tg) mouse model, and an imiquimod-induced psoriasis mouse model. First, we found that IL-35 suppressed the expression of IL-6, CXCL8, and S100A7, which are highly upregulated by a mixture of five proinflammatory cytokines in HaCaT. Second, a plasmid coding for the human IL-35 sequence coated with cationic liposomes showed potent immunosuppressive effects on K14-VEGF-A-Tg and imiquimod-induced psoriasis mouse models. In the K14-VEGF-A-Tg model, our results showed that several types of proinflammatory cytokines were significantly reduced, whereas IL-10 was remarkably induced by IL-35. Compared with pcDNA3.1, there was a small number of CD4+IL-17+ T cells and a large number of CD4+IL-10+ and CD4+CD25+Foxp3+ T cells in the IL-35 group. Most importantly, we found that IL-35 decreased the total number of macrophages and ratio of M1\/M2 macrophages, which has not been reported previously. In addition, compared with dexamethasone, IL-35 showed long-term therapeutic efficacy. In summary, our results strongly indicate that IL-35 plays a potent immunosuppressive role in psoriasis. Thus, IL-35 has potential for development as a new therapeutic strategy for patients with chronic psoriasis and other cutaneous inflammatory diseases.<\/jats:p>","DOI":"10.4049\/jimmunol.1600446","type":"journal-article","created":{"date-parts":[[2016,8,15]],"date-time":"2016-08-15T20:33:19Z","timestamp":1471293199000},"page":"2131-2144","source":"Crossref","is-referenced-by-count":90,"title":["IL-35 Decelerates the Inflammatory Process by Regulating Inflammatory Cytokine Secretion and M1\/M2 Macrophage Ratio in Psoriasis"],"prefix":"10.1093","volume":"197","author":[{"given":"Junfeng","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Biotherapy\/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University , Chengdu, Sichuan 610041,","place":["China"]},{"name":"Provincial Key Discipline of Medical Immunology, Jining Medical University , Jining 272067, Shandong,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Lin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy\/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University , Chengdu, Sichuan 610041,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlei","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy\/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University , Chengdu, Sichuan 610041,","place":["China"]},{"name":"Department of Biochemistry, Faculty of Basic Medicine, Chongqing Three Gorges Medical College , Chongqing 400715,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laboratory Animal Center, Sichuan University , Chengdu 610040, Sichuan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Cheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy\/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University , Chengdu, Sichuan 610041,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Dai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy\/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University , Chengdu, Sichuan 610041,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youcui","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy\/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University , Chengdu, Sichuan 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610041,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianmei","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy\/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University , Chengdu, Sichuan 610041,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueliang","family":"Cui","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy\/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University , Chengdu, Sichuan 610041,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy\/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University , Chengdu, Sichuan 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