{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:22:59Z","timestamp":1789654979495,"version":"4.0.1"},"reference-count":153,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Vaccines afford a better and more cost-effective approach to combatting infectious diseases than continued reliance on antibiotics or antiviral or antiparasite drugs in the current era of increasing incidences of diseases caused by drug-resistant pathogens. Recombinant attenuated Salmonella vaccines (RASVs) have been significantly improved to exhibit the same or better attributes than wild-type parental strains to colonize internal lymphoid tissues and persist there to serve as factories to continuously synthesize and deliver rAgs. Encoded by codon-optimized pathogen genes, Ags are selected to induce protective immunity to infection by that pathogen. After immunization through a mucosal surface, the RASV attributes maximize their abilities to elicit mucosal and systemic Ab responses and cell-mediated immune responses. This article summarizes many of the numerous innovative technologies and discoveries that have resulted in RASV platforms that will enable development of safe efficacious RASVs to protect animals and humans against a diversity of infectious disease agents.<\/jats:p>","DOI":"10.4049\/jimmunol.1600608","type":"journal-article","created":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T21:40:16Z","timestamp":1513633216000},"page":"39-48","source":"Crossref","is-referenced-by-count":66,"title":["<i>Salmonella<\/i> Vaccines: Conduits for Protective Antigens"],"prefix":"10.1093","volume":"200","author":[{"given":"Josephine E","family":"Clark-Curtiss","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases and Global Medicine, Department of Medicine, College of Medicine, University of Florida , Gainesville, FL 32610"},{"name":"Emerging Pathogens Institute, University of Florida , Gainesville, FL 32611"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Roy","family":"Curtiss","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida , Gainesville, FL 32611"},{"name":"Department of Comparative, Diagnostic and Population Medicine, College of Veterinary Medicine, University of Florida , Gainesville, FL 32611"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,1,1]]},"reference":[{"key":"2025030610003784400_r1","volume-title":"The ten leading causes of death in the world, 2000 and 2012","author":"World Health Organization","year":"2014"},{"key":"2025030610003784400_r2","first-page":"226","article-title":"On the antibacterial action of cultures of a Penicillium, with special reference to their use in the isolation of B. influenzae","volume":"10","author":"Fleming","year":"1929","journal-title":"Br. 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